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2-bromo-4-chloro-1-(difluoromethoxy)benzene

Product Name
2-bromo-4-chloro-1-(difluoromethoxy)benzene
CAS No.
1214348-81-8
Chemical Name
2-bromo-4-chloro-1-(difluoromethoxy)benzene
Synonyms
2-bromo-4-chloro-1-(difluoromethoxy)benzene;Benzene, 2-bromo-4-chloro-1-(difluoromethoxy)-
CBNumber
CB51557706
Molecular Formula
C7H4BrClF2O
Formula Weight
257.46
MOL File
1214348-81-8.mol
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2-bromo-4-chloro-1-(difluoromethoxy)benzene Property

storage temp. 
Sealed in dry,Room Temperature
Appearance
Colorless to light yellow Liquid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B683953
Product name
2-Bromo-4-chloro-1-(difluoromethoxy)benzene
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
B683953
Product name
2-Bromo-4-chloro-1-(difluoromethoxy)benzene
Packaging
250mg
Price
$125
Updated
2021/12/16
TRC
Product number
B683953
Product name
2-Bromo-4-chloro-1-(difluoromethoxy)benzene
Packaging
500mg
Price
$195
Updated
2021/12/16
TRC
Product number
B683953
Product name
2-Bromo-4-chloro-1-(difluoromethoxy)benzene
Packaging
1g
Price
$275
Updated
2021/12/16
AK Scientific
Product number
Z8318
Product name
2-Bromo-4-chloro-1-(difluoromethoxy)benzene
Packaging
1g
Price
$218
Updated
2021/12/16
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2-bromo-4-chloro-1-(difluoromethoxy)benzene Chemical Properties,Usage,Production

Synthesis

695-96-5

1895-39-2

1214348-81-8

To a solution of 2-bromo-4-chlorophenol (4.98 g, 24.0 mmol) in N,N-dimethylformamide (DMF, 25 mL) was sequentially added sodium difluorochloroacetate (8.42 g, 55.2 mmol), cesium carbonate (10.97 g, 33.67 mmol) and water (2.5 mL). The reaction mixture was stirred at 100 °C for 16 hours. After completion of the reaction, the mixture was partitioned between ethyl acetate and water, and the organic phase was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel fast column chromatography eluting with 0-20% ethyl acetate/heptane gradient to afford 2-bromo-4-chloro-1-(difluoromethoxy)benzene as a colorless, transparent oil (2.98 g, 48% yield).No molecular ion peak was detected by LC-MS (ESI); 1H NMR (400 MHz, DMSO-d6) δ: 7.90 (d, 1H) , 7.54 (dd, 1H), 7.38 (d, 1H), 7.28 (t, 1H).

References

[1] Patent: US2014/315933, 2014, A1. Location in patent: Paragraph 0556; 0557; 0558
[2] Patent: US2015/336962, 2015, A1. Location in patent: Paragraph 0638
[3] Patent: WO2018/166993, 2018, A2. Location in patent: Page/Page column 92
[4] Patent: WO2011/3065, 2011, A2. Location in patent: Page/Page column 99

2-bromo-4-chloro-1-(difluoromethoxy)benzene Preparation Products And Raw materials

Raw materials

Preparation Products

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2-bromo-4-chloro-1-(difluoromethoxy)benzene Suppliers

China 57 India 1 United States 6 Global 64
Adamas Reagent, Ltd.
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View Lastest Price from 2-bromo-4-chloro-1-(difluoromethoxy)benzene manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2-bromo-4-chloro-1-(difluoromethoxy)benzene 1214348-81-8
Price
US $1.60-9.60/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-20
Henan Aochuang Chemical Co.,Ltd.
Product
2-bromo-4-chloro-1-(difluoromethoxy)benzene 1214348-81-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-29
Shanghai Rlavie Technology Co ltd
Product
2-bromo-4-chloro-1-(difluoromethoxy)benzene 1214348-81-8
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
100kgs/month
Release date
2022-01-03

1214348-81-8, 2-bromo-4-chloro-1-(difluoromethoxy)benzeneRelated Search:

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