ChemicalBook > CAS DataBase List > Cycloguanil Hydrochloride

Cycloguanil Hydrochloride

Product Name
Cycloguanil Hydrochloride
CAS No.
152-53-4
Chemical Name
Cycloguanil Hydrochloride
Synonyms
uaniL;BN 2410;oguaniL;NSC 3074;NSC 3074-d4;Chloroprimidine;Chloroguanide Triazine;Cycloguanil Hydrochloride;Cycloguanil-d4 Hydrochloride;Cycloguanidine hydrochloride
CBNumber
CB51564793
Molecular Formula
C11H14ClN5.ClH
Formula Weight
288.181
MOL File
152-53-4.mol
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Cycloguanil Hydrochloride Property

Melting point:
210-2150C
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO (Slightly, Sonicated), Methanol (Slightly), Water (Slightly)
form 
Solid
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S392502
Product name
1-(4-CHLOROPHENYL)-4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1,3,5-TRIAZINE HCL
Purity
AldrichCPR
Packaging
50MG
Price
$179
Updated
2024/03/01
Cayman Chemical
Product number
16861
Product name
Cycloguanil (hydrochloride)
Purity
≥95%
Packaging
5mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
16861
Product name
Cycloguanil (hydrochloride)
Purity
≥95%
Packaging
10mg
Price
$55
Updated
2024/03/01
Cayman Chemical
Product number
16861
Product name
Cycloguanil (hydrochloride)
Purity
≥95%
Packaging
25mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
16861
Product name
Cycloguanil (hydrochloride)
Purity
≥95%
Packaging
50mg
Price
$139
Updated
2024/03/01
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Cycloguanil Hydrochloride Chemical Properties,Usage,Production

Description

Cycloguanil is the active metabolite of the antimalarial prodrug proguanil. Cycloguanil is formed from proguanil by the cytochrome P450 (CYP) isoforms CYP2C19 and CYP3A in human liver microsomes. It is an inhibitor of dihydrofolate reductase (DHFR; Kis = 1.5 and 0.79 nM for the P. falciparum and P. berghei enzymes, respectively). It is active against ten P. falciparum field isolates (IC50s = 0.12-1,400 μg/ml). Cycloguanil reduces parasitemia in a mouse model of P. berghei infection (ED50 = 2 mg/kg). It also reduces parasitemia in a rhesus monkey model of P. cynomolgi infection when administered at a dose of 0.3 mg/kg.

Chemical Properties

Crystalline Solid

Uses

Labelled antimalarial drug

Uses

Antimalarial drug.

Definition

ChEBI: Cycloguanil hydrochloride is the hydrochloride salt of cycloguanil. It is an organic molecular entity and a hydrochloride. It contains a cycloguanil.

References

[1] foote s j, galatis d, cowman a f. amino acids in the dihydrofolate reductase-thymidylate synthase gene of plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance[j]. proceedings of the national academy of sciences, 1990, 87(8): 3014-3017.
[2] blakley r l. dihydrofolate reductase[j]. encyclopedia of molecular medicine, 1984.
[3] birkett d j, rees d, andersson t, et al. in vitro proguanil activation to cycloguanil by human liver microsomes is mediated by cyp3a isoforms as well as by s‐mephenytoin hydroxylase[j]. british journal of clinical pharmacology, 1994, 37(5): 413-420.

Cycloguanil Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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152-53-4, Cycloguanil HydrochlorideRelated Search:

N,N-Dimethyl-1,4-phenylenediamine Diphenyl sulfone

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