Cycloguanil Hydrochloride
- Product Name
- Cycloguanil Hydrochloride
- CAS No.
- 152-53-4
- Chemical Name
- Cycloguanil Hydrochloride
- Synonyms
- uaniL;BN 2410;oguaniL;NSC 3074;NSC 3074-d4;Chloroprimidine;Chloroguanide Triazine;Cycloguanil Hydrochloride;Cycloguanil-d4 Hydrochloride;Cycloguanidine hydrochloride
- CBNumber
- CB51564793
- Molecular Formula
- C11H14ClN5.ClH
- Formula Weight
- 288.181
- MOL File
- 152-53-4.mol
Cycloguanil Hydrochloride Property
- Melting point:
- 210-2150C
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO (Slightly, Sonicated), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S392502
- Product name
- 1-(4-CHLOROPHENYL)-4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1,3,5-TRIAZINE HCL
- Purity
- AldrichCPR
- Packaging
- 50MG
- Price
- $179
- Updated
- 2024/03/01
- Product number
- 16861
- Product name
- Cycloguanil (hydrochloride)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 16861
- Product name
- Cycloguanil (hydrochloride)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $55
- Updated
- 2024/03/01
- Product number
- 16861
- Product name
- Cycloguanil (hydrochloride)
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- 16861
- Product name
- Cycloguanil (hydrochloride)
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $139
- Updated
- 2024/03/01
Cycloguanil Hydrochloride Chemical Properties,Usage,Production
Description
Cycloguanil is the active metabolite of the antimalarial prodrug proguanil. Cycloguanil is formed from proguanil by the cytochrome P450 (CYP) isoforms CYP2C19 and CYP3A in human liver microsomes. It is an inhibitor of dihydrofolate reductase (DHFR; Kis = 1.5 and 0.79 nM for the P. falciparum and P. berghei enzymes, respectively). It is active against ten P. falciparum field isolates (IC50s = 0.12-1,400 μg/ml). Cycloguanil reduces parasitemia in a mouse model of P. berghei infection (ED50 = 2 mg/kg). It also reduces parasitemia in a rhesus monkey model of P. cynomolgi infection when administered at a dose of 0.3 mg/kg.
Chemical Properties
Crystalline Solid
Uses
Labelled antimalarial drug
Uses
Antimalarial drug.
Definition
ChEBI: Cycloguanil hydrochloride is the hydrochloride salt of cycloguanil. It is an organic molecular entity and a hydrochloride. It contains a cycloguanil.
References
[1] foote s j, galatis d, cowman a f. amino acids in the dihydrofolate reductase-thymidylate synthase gene of plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance[j]. proceedings of the national academy of sciences, 1990, 87(8): 3014-3017.
[2] blakley r l. dihydrofolate reductase[j]. encyclopedia of molecular medicine, 1984.
[3] birkett d j, rees d, andersson t, et al. in vitro proguanil activation to cycloguanil by human liver microsomes is mediated by cyp3a isoforms as well as by s‐mephenytoin hydroxylase[j]. british journal of clinical pharmacology, 1994, 37(5): 413-420.
Cycloguanil Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Cycloguanil Hydrochloride Suppliers
View Lastest Price from Cycloguanil Hydrochloride manufacturers
- Product
- Cycloguanil hydrochloride 152-53-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000KG
- Release date
- 2024-07-16