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ChemicalBook > CAS DataBase List > HUMAN RANTES

HUMAN RANTES

Description Source Background
Product Name
HUMAN RANTES
CAS No.
1927910-48-2
Chemical Name
HUMAN RANTES
Synonyms
CCL8;HC14;MCP-2;SCYA8;SCYA10;RHRANTES;HUMAN CCL5;MCP-2, HUMAN;HUMAN RANTES;RANTES, HUMAN
CBNumber
CB5157790
Formula Weight
0
MOL File
Mol file
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HUMAN RANTES Property

storage temp. 
−20°C
form 
lyophilized powder
color 
white
biological source
mouse
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Safety

Hazard Codes 
T,Xn,F
Risk Statements 
23/24/25-36/37/38-36-20/21/22-11
Safety Statements 
26-36/37/39-45-36/37-16
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SRP3269
Product name
RANTES human
Purity
Animal-component free, recombinant, expressed in <I>E. coli</I>, &#8805;98% (SDS-PAGE), &#8805;98% (HPLC)
Packaging
20 μg
Price
$452
Updated
2025/07/31
Usbiological
Product number
R1100-05D
Product name
RANTES, Human
Packaging
96Tests
Price
$835
Updated
2021/12/16
Biorbyt Ltd
Product number
orb527550
Product name
CCL8
Packaging
10μg
Price
$290.7
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CYT0000037
Product name
CCL-8
Purity
95.00%
Packaging
5MG
Price
$502.7
Updated
2021/12/16
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HUMAN RANTES Chemical Properties,Usage,Production

Uses

RANTES human has been used in following studies:

  • In transmigration experiments to determine whether LFA-1 cross-linking could affect peripheral blood T lymphocytes (PBTL) migration in response to the chemokine RANTES.
  • Luminol-dependent chemiluminescence assay to determine the effect of RANTES on reactive oxygen species (ROS) production by eosinophils.

Biological Activity

Regulated on activation, normal T cell expressed and secreted (RANTES) is a chemoattractant towards monocytes, dendritic cells (DCs), memory T cells (CD4+/CD45RO), basophils, and eosinophils. The encoded chemokine protein functions as a ligand for CCR1, CCR3, and CCR5.1 RANTES inhibits the action of R5 strains of HIV-1 via blocking CCR5 receptor. The In1.1C variant of RANTES gene is linked with susceptibility to HIV-1 infection and disease progression. Hence, this can be used as a potent biomarker to determine the prognosis of HIV-1 infection.

Description

Monocyte Chemotactic Protein-2 Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 76 amino acids and having a molecular mass of 8904 Dalton.
The MCP2 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli

Background

Regulated upon Activation, Normal T-cell Expressed, and Secreted or RANTES is an 8 kDa protein classified as a chemotactic cytokine or chemokine. Rantes has recently been renamed CCL5. RANTES is chemotactic for T cells, eosinophils and basophils and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines (i.e. IL-2 and IFN-g) that are released by T cells, RANTES also induces the proliferation and activation of certain natural killer (NK) cells to form CHAK (CC-Chemokine-activated killer) cells. Rantes is also an HIV-suppressive factor released from CD8+ T cells. The Rantes chemokine has been localized to chromosome 17 in humans.

HUMAN RANTES Preparation Products And Raw materials

Raw materials

Preparation Products

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HUMAN RANTES Suppliers

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1927910-48-2, HUMAN RANTESRelated Search:


  • HUMAN SIS-DELTA
  • HUMAN MCP2 (CCL8)
  • HUMAN MCP2 (CCL8) CHEMICALLY SYNTHESIZED CHEMOKINE
  • HUMAN CCL5
  • REC RANTES (HUMAN)
  • RECOMBINANT HUMAN RANTES
  • RHRANTES
  • RANTES [HOMO SAPIENS]
  • RANTES, HUMAN
  • RANTES, HUMAN, RECOMBINANT
  • MONOCYTE CHEMOTACTIC PROTEIN-2 (HUMAN)
  • MCP-2
  • Regulated on Activation, Normal T-cell Expressed and Secreted
  • H-Ser-Pro-Tyr-Ser-Ser-Asp-Thr-Thr-Pro-Cys-Cys-Phe-Ala-Tyr-Ile-Ala-Arg-Pro-Leu-Pro-Arg-Ala-His-Ile-Lys-Glu-Tyr-Phe-Tyr-Thr-Ser-Gly-Lys-Cys-Ser-Asn-Pro-Ala-Val-Val-Phe-Val-Thr-Arg-Lys-Asn-Arg-Gln-Val-Cys-Ala-Asn-Pro-Glu-Lys-Lys-Trp-Val-Arg-Glu-Tyr-Ile-Asn-Ser-Leu-Glu-Met-Ser-OH
  • SMall-Inducible Cytokine A5, CCL5, T Cell-Specific Protein P228, TCP228
  • CCL8
  • HC14
  • MCP-2 from mouse
  • Monocyte chemotactic protein 2
  • Small inducible cytokine A8
  • MACROPHAGE/MONOCYTE CHEMOTACTIC PROTEIN-2, HUMAN
  • MCP-2, HUMAN
  • HUMAN REGULATED UPON ACTIVATION NORMAL T CELL EXPRESSED SEQUENCE
  • HUMAN RANTES
  • HUMAN RANTES (CCL5)
  • HUMAN RANTES (CCL5) CHEMICALLY SYNTHESIZED CHEMOKINE
  • Recombinant Human CCL8/MCP-2 Protein, His Tag
  • Recombinant Human CCL8/MCP-2 Protein, No Tag
  • Recombinant Mouse Ccl8/MCP-2 Protein, His Tag
  • Human CCL8 Protein, His Tag
  • CCL5, TCP228, Small-Inducible Cytokine A5, T Cell-
  • Recombinant Human CCL8/MCP-2 Protein (Human Cells, His Tag)
  • SCYA10
  • SCYA8
  • 1927910-48-2