4-METHOXYPHENETHYL ALCOHOL Property

Melting point:

26-28 °C(lit.)

Boiling point:

334-336 °C(lit.)

Density 

1.058±0.06 g/cm3 (20 ºC 760 Torr)

refractive index 

1.536-1.538

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Soluble in DMSO, Methanol.

form 

Liquid After Melting

pka

15.00±0.16(Predicted)

color 

Clear light brown

FreezingPoint 

23.0 to 28.0 ℃

BRN 

2043563

LogP

1.393 (est)

CAS DataBase Reference

702-23-8(CAS DataBase Reference)

EPA Substance Registry System

4-Methoxybenzeneethanol (702-23-8)

Safety

Safety Statements 

24/25

WGK Germany 

3

TSCA 

Yes

HS Code 

29062990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

4-METHOXYPHENETHYL ALCOHOL Chemical Properties,Usage,Production

Chemical Properties

clear light brown liquid after melting

Uses

2-(4-Methoxyphenyl)ethanol is used as an internal standard in the fluorous biphasic catalysis reaction. It is used in the preparation of 4-(2-iodoethyl)phenol, by refluxing it with 47% hydriodic acid. It may be used in the preparation of (2R*,4R*)-1-n-butyl-2-methyl-4-(2-oxopyrrolidin-1-yl)-6-methoxy-1,2,3,4-tetrahydroquinoline and (2R*,4S*)-1-n-butyl-2-methyl-4-(2-oxopyrrolidin-1-yl)-6-methoxy-1,2,3,4- tetrahydroquinoline. It is used for foods, perfumes, and cosmetics.

Uses

4-Methoxyphenethyl alcohol was used in the preparation of 4-(2-iodoethyl)phenol, by refluxing it with 47% hydriodic acid. It may be used in the preparation of (2R^*,4R^*)-1-n-butyl-2-methyl-4-(2-oxopyrrolidin-1-yl)-6-methoxy-1,2,3,4-tetrahydroquinoline and (2R^*,4S^*)-1-n-butyl-2-methyl-4-(2-oxopyrrolidin-1-yl)-6-methoxy-1,2,3,4- tetrahydroquinoline.

Uses

4-Methoxyphenethyl alcohol has a flavor and aroma of fresh citrus juice and may be used for perfumes, foods, and cosmetics.

Synthesis Reference(s)

Journal of the American Chemical Society, 82, p. 3222, 1960 DOI: 10.1021/ja01497a062
Tetrahedron Letters, 33, p. 7465, 1992 DOI: 10.1016/S0040-4039(00)60796-7

General Description

(R)-1-(4-methoxyphenyl)ethanol {(R)-MOPE, 4-Methoxyphenethyl alcohol, 1-(4-methoxyphenyl)ethanol } is formed during the biocatalytic anti-Prelog enantioselective reduction of 4-methoxyacetophenone (MOAP) using immobilized Trigonopsis variabilis AS2.