ChemicalBook > CAS DataBase List > 1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID

1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID

Product Name
1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID
CAS No.
306935-41-1
Chemical Name
1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID
Synonyms
IBC 293;IPBT-5CA;BUTTPARK 36\04-50;IBC 293, 10 mM in DMSO;GPR109 receptor agonist-1;1-ISOPROPYLBENZOTRIAZOLE-5-CARBOXYLIC ACID;1-propan-2-ylbenzotriazole-5-carboxylic acid;1-propan-2-yl-5-benzotriazolecarboxylic acid;1-ISOPROPYL-1H-BENZOTRIAZOLE-5-CARBOXYLIC ACID;1-Isopropyl-1,2,3-benzotriazole-5-carboxylic acid
CBNumber
CB5160800
Molecular Formula
C10H11N3O2
Formula Weight
205.21
MOL File
306935-41-1.mol
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1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID Property

Melting point:
229-230°C
Boiling point:
413.9±18.0 °C(Predicted)
Density 
1.37±0.1 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
Soluble in DMSO (up to 25 mg/ml).
form 
Light brown solid
pka
3.50±0.30(Predicted)
color 
Off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference
306935-41-1(CAS DataBase Reference)
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
Hazard Note 
Irritant
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
15223
Product name
IPBT-5CA
Purity
≥98%
Packaging
50mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
15223
Product name
IPBT-5CA
Purity
≥98%
Packaging
1g
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
15223
Product name
IPBT-5CA
Purity
≥98%
Packaging
100mg
Price
$50
Updated
2024/03/01
Cayman Chemical
Product number
15223
Product name
IPBT-5CA
Purity
≥98%
Packaging
500mg
Price
$153
Updated
2024/03/01
Tocris
Product number
2469
Product name
IBC293
Purity
≥99%(HPLC)
Packaging
10
Price
$96
Updated
2021/12/16
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1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID Chemical Properties,Usage,Production

Description

IPBT-5CA (306935-41-1) is a highly selective agonist for the human orphan G-protein-coupled receptor GPR109b (EC50 = 400 nM). No activity was reported at the highly homologous high-affinity niacin receptor GPR109a.

Definition

ChEBI: 1-propan-2-yl-5-benzotriazolecarboxylic acid is a member of benzotriazoles.

Biological Activity

Highly selective agonist for GPR109B (HM74), the human orphan G-protein-coupled receptor expressed in adipocytes. Selective for GPR109B over closely related niacin receptor GPR109A (HM74A); EC 50 values are 400 nM and > 1 μ M respectively. In vitro, inhibits isoproterenol-stimulated lipolysis in isolated human adipocytes.

References

1) Semple et al. (2006) 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b; J. Med. Chem., 49 1227

1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID Suppliers

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View Lastest Price from 1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID manufacturers

Shanghai UCHEM Inc.
Product
1-Isopropyl-1H-1,2,3-Benzotriazole-5-Carboxylic Acid 306935-41-1
Price
US $104.00-597.00/g
Min. Order
1g
Purity
0.98
Supply Ability
25kg
Release date
2023-12-21
Career Henan Chemical Co
Product
1-propan-2-ylbenzotriazole-5-carboxylic acid 306935-41-1
Price
US $0.01/KG
Min. Order
1KG
Purity
98%; 99%
Supply Ability
500g;1kg； 25kg
Release date
2020-01-09

306935-41-1, 1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACIDRelated Search:

Zafirlukast 6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID SC-51089 Benzotriazole-5-carboxylic acid 1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID 1-CYCLOHEXYL-1H-BENZOTRIAZOLE-5-CARBOXYLIC ACID 1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID BUTTPARK 147\04-50 1-CYCLOBUTYL-1H-BENZOTRIAZOLE-5-CARBOXYLIC ACID 1-SEC-BUTYL-1H-BENZOTRIAZOLE-5-CARBOXYLIC ACID 1-(pentan-2-yl)-1H-1,2,3-benzotriazole-5-carboxylic acid 1-CYCLOPROPYL-1H-BENZOTRIAZOLE-5-CARBOXYLIC ACID 1-(1-ETHYL-PROPYL)-1H-BENZOTRIAZOLE-5-CARBOXYLIC ACID 1-(2-METHOXY-1-METHYL-ETHYL)-1H-BENZOTRIAZOLE-5-CARBOXYLIC ACID 1-CYCLOPENTYL-1H-BENZOTRIAZOLE-5-CARBOXYLIC ACID 1-BENZHYDRYL-1H-BENZOTRIAZOLE-5-CARBOXYLIC ACID 1-TERT-BUTYL-1H-BENZOTRIAZOLE-5-CARBOXYLIC ACID BUTTPARK 48\04-39

  • BUTTPARK 36\04-50
  • IBC 293
  • IPBT-5CA
  • 1-ISOPROPYL-1H-BENZO[D][1,2,3]TRIAZOLE-5-CARBOXYLIC ACID
  • 1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID
  • 1-ISOPROPYL-1H-BENZOTRIAZOLE-5-CARBOXYLIC ACID
  • 1-ISOPROPYLBENZOTRIAZOLE-5-CARBOXYLIC ACID
  • 1-(1-METHYLETHYL)-1H-BENZOTRIAZOLE-5-CARBOXYLIC ACID
  • 1-Isopropyl-1,2,3-benzotriazole-5-carboxylic acid
  • 1-(Prop-2-yl)-1H-benzotriazole-5-carboxylic acid, 5-Carboxy-1-isopropyl-1H-benzotriazole
  • 1-propan-2-ylbenzotriazole-5-carboxylic acid
  • 1-propan-2-yl-5-benzotriazolecarboxylic acid
  • 1H-Benzotriazole-5-carboxylic acid, 1-(1-methylethyl)-
  • GPR109 receptor agonist-1
  • GPR109b,GPR109A,HCAR2,PUMA-G,Inhibitor,GPR109 receptor agonist-1,HCA2,inhibit,cardio-metabolic diseases,IBC 293,HM74A
  • IBC 293, 10 mM in DMSO
  • 306935-41-1