2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE

Product Name: 2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE
CAS No.: 456-00-8
Chemical Name: 2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE
Synonyms: 2-Amino-4-fluoroacetophenone hcl;2-Amino-4'-fluoroacetophenone, HCl;4-FLUOROPHENACYLAMINE HYDROCHLORIDE;2-(4-FLUORO-PHENYL)-2-OXO-ETHYL-AMMONIUM;2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE;[2-(4-fluorophenyl)-2-oxoethyl]azanium chloride;[2-(4-fluorophenyl)-2-oxo-ethyl]azanium chloride;[2-(4-fluorophenyl)-2-keto-ethyl]ammonium chloride;2-(4-FLUORO-PHENYL)-2-OXO-ETHYL-AMMONIUM, CHLORIDE;2-AMINO-1-(4-FLUORO-PHENYL)-ETHANONE HYDROCHLORIDE
CBNumber: CB5172155
Molecular Formula: C8H9ClFNO
Formula Weight: 189.61
MOL File: 456-00-8.mol

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2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE Property

Melting point:: 235-238
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: crystalline needles
color: White
InChI: InChI=1S/C8H8FNO.ClH/c9-7-3-1-6(2-4-7)8(11)5-10;/h1-4H,5,10H2;1H
InChIKey: KQROOJFZQSQJMM-UHFFFAOYSA-N
SMILES: C(C1=CC=C(F)C=C1)(=O)CN.[H]Cl
CAS DataBase Reference: 456-00-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
HazardClass: IRRITANT
HS Code: 2922390090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: A630560
Product name: 2-Amino-1-(4-fluorophenyl)ethanoneHydrochloride
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: J93916
Product name: 2-Amino-4'-fluoroacetophenonehydrochloride
Packaging: 1g
Price: $30
Updated: 2021/12/16

Apolloscientific

Product number: PC4576
Product name: 4-Fluorophenacylaminehydrochloride
Purity: 95%
Packaging: 1g
Price: $35
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4656-7-05
Product name: 4-Fluorophenacylamine hydrochloride
Purity: 95%
Packaging: 1g
Price: $39
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA70081
Product name: 2-Amino-4'-fluoroacetophenone hydrochloride
Packaging: 5G
Price: $50
Updated: 2021/12/16

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2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE Chemical Properties,Usage,Production

Synthesis

403-29-2

456-00-8

The general procedure for the synthesis of α-amino-p-fluoroacetophenone hydrochloride from 2-bromo-4'-fluoroacetophenone was as follows: Intermediate 5A was prepared by the method described in PCT Publication No. WO 2009/137081 (PCT US2009/002845), which was carried out as follows: To a solution of chloroform (65.5 mL) containing 2-bromo-1-(4-fluorophenyl)ethanone (6.57 g, 30.3 mmol) Hexamethylenetetramine (4.37 g, 30.8 mmol) was added to a solution of chloroform (65.5 mL) containing 2-bromo-1-(4-fluorophenyl)ethanone (6.57 g, 30.3 mmol). The reaction mixture was stirred at room temperature for 16 hours and then filtered to collect a white solid. The solid was suspended in methanol (130 mL) followed by the slow addition of concentrated hydrochloric acid (~8.6 mL). The resulting homogeneous reaction mixture was refluxed for 4 hours. Upon completion of the reaction, the mixture was cooled, filtered to remove the inorganic salt, and the filter cake was washed with methanol (~30 mL). The filtrates were combined and concentrated under reduced pressure to give a solid product, which was then dried under high vacuum for 2 hours. Further purification by silica gel column chromatography (using a Thomson BIOTAGE column eluting with a gradient of 5% to 20% dichloromethane solution in methanol) gave a red solid product. The solid was dissolved in a small amount of dichloromethane and filtered to give Intermediate 5A as a colorless solid (5.44 g, 95% yield).HPLC retention time: 0.90 min (Method D). Mass spectrum (electrospray ionization): m/z = 136.05 [M + H]+.

References

[1] Patent: WO2014/100533, 2014, A1. Location in patent: Page/Page column 72; 73
[2] Patent: US2018/297990, 2018, A1. Location in patent: Paragraph 0244
[3] Journal of Medicinal Chemistry, 1982, vol. 25, # 9, p. 1045 - 1050
[4] Synlett, 2004, # 11, p. 2031 - 2033
[5] Chemical and Pharmaceutical Bulletin, 2015, vol. 63, # 8, p. 628 - 635

2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE Suppliers

Austria 1 China 84 Germany 2 Hungary 1 India 2 United Kingdom 13 United States 18 Global 121

Hotechem Shanghai Co., Ltd.,

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View Lastest Price from 2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE manufacturers

Career Henan Chemica Co

Product: 2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE 456-00-8
Price: US $1.30/g
Min. Order: 1g
Purity: 98%
Supply Ability: 10kg
Release date: 2020-10-27

456-00-8, 2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDERelated Search:

4-Fluoroacetophenone α-Amino-4’-fluoroacetophenone hydrochloride,a-Amino-4-fluoroacetophenone hydrochloride 2-AMINO-3'-FLUOROACETOPHENONE HYDROCHLORIDE

4-FLUOROPHENACYLAMINE HYDROCHLORIDE

2-(4-FLUORO-PHENYL)-2-OXO-ETHYL-AMMONIUM, CHLORIDE

2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE

2-AMINO-1-(4-FLUOROPHENYL)-1-ETHANONE HYDROCHLORIDE

2-AMINO-1-(4-FLUORO-PHENYL)-ETHANONE HYDROCHLORIDE

2-(4-FLUORO-PHENYL)-2-OXO-ETHYL-AMMONIUM

2-Amino-4-fluoroacetophenone hcl

2-Amino-1-(4-fluorophenyl)ethan-1-one hydrochloride, 2-Amino-4'-fluoroacetophenone hydrochloride

2-aMino-1-(4-fluorophenyl)ethan-1-one hydrochloride

Ethanone, 2-amino-1-(4-fluorophenyl)-, hydrochloride (1:1)

[2-(4-fluorophenyl)-2-keto-ethyl]ammonium chloride

[2-(4-fluorophenyl)-2-oxoethyl]azanium chloride

[2-(4-fluorophenyl)-2-oxo-ethyl]azanium chloride

Ethanone, 2-amino-1-(4-fluorophenyl)-, hydrochloride

2-Amino-4'-fluoroacetophenone, HCl

456-00-8

C8H8NOF

C8H8FNOHCl

C8H9ClFNO

Aromatic Acetophenones & Derivatives (substituted)