ChemicalBook > CAS DataBase List > Z-FL-COCHO

Z-FL-COCHO

Product Name
Z-FL-COCHO
CAS No.
1373215-15-6
Chemical Name
Z-FL-COCHO
Synonyms
LY 3000328;Z-FL-COCHO;CATHEPSIN S INHIBITOR;LY 3000328, 10 mM in DMSO;LY3000328，Cathepsin S inhibitor;CATHEPSIN S INHIBITOR ;LY-3000328;LY3000328;Cathepsin,LY3000328,LY 3000328,Inhibitor,LY-3000328,inhibit;(3R,4S)-4-(4-fluorobenzamido)-6-(4-(oxetan-3-yl)piperazin-1-yl)chroman-3-yl methylcarbamate;((3R,4S)-4-((4-FLUOROBENZOYL)AMINO)-6-(4-(OXETAN-3-YL)PIPERAZIN-1-YL)CHROMAN-3-YL)N-METHYLCARBAMATE;N-[(3R,4S)-3,4-Dihydro-3-[[(methylamino)carbonyl]oxy]-6-[4-(3-oxetanyl)-1-piperazinyl]-2H-1-benzopyran-4-yl]-4-fluorobenzamide
CBNumber
CB5175767
Molecular Formula
C25H29FN4O5
Formula Weight
484.52
MOL File
Mol file
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Z-FL-COCHO Property

Boiling point:
701.6±60.0 °C(Predicted)
Density 
1.38±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≥24.25 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form 
Powder
pka
12.50±0.46(Predicted)
color 
White to off-white
InChIKey
NDEBZCZEAVMSQF-GOTSBHOMSA-N
SMILES
C(N[C@H]1C2=CC(N3CCN(C4COC4)CC3)=CC=C2OC[C@@H]1OC(NC)=O)(=O)C1=CC=C(F)C=C1
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29729
Product name
LY3000328
Packaging
500μg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
29729
Product name
LY3000328
Packaging
10mg
Price
$632
Updated
2024/03/01
Cayman Chemical
Product number
29729
Product name
LY3000328
Packaging
1mg
Price
$152
Updated
2024/03/01
Cayman Chemical
Product number
29729
Product name
LY3000328
Packaging
5mg
Price
$356
Updated
2024/03/01
TRC
Product number
L468955
Product name
LY3000328
Packaging
1mg
Price
$275
Updated
2021/12/16
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Z-FL-COCHO Chemical Properties,Usage,Production

Description

LY3000328 is a potent cathepsin S inhibitor (IC50 = 7.7 nM for the human enzyme). It is selective for cathepsin S over cathepsin L, K, B, and V (IC50s = >10,000, >10,000, 4,390, and 21,500 nM, respectively). LY3000328 (1-30 mg/kg) reduces aortic diameter in a mouse model of calcium chloride-induced abdominal aortic aneurysm.

Uses

LY 3000328 is a cathepsin S inhibitor for treatment of abdominal aortic aneurysm. Further provides methods for treating plaque instability, atherosclerosis, or autoimmune disorders such as rheumatoid arthritis, psoriasis, and lupus comprising administering a therapeutically effective amount of a disclosed compound.

in vivo

The efficacies of LY 3000328 is studied in a mouse model of abdominal aortic aneurysm (AAA). In this model, inflammation is induced using CaCl2 applied to the ablumenal surface. It is shown that features of the disease state in this model resemble those of human AAA. LY 3000328 exhibits a dose-responsive aortic diameter reduction at 1, 3, 10, and 30 mg/kg. At the lowest dose of 1 mg/kg of LY 3000328, the aortic diameter is reduced by 58%, then 83% at 3 mg/kg, and 87% at 10 mg/kg. The exposure (AUC) for both compounds increased in a dose-dependent manner, suggesting that the drug disposition properties of LY 3000328 are favorable[1].

target

cathepsin S

IC 50

cathepsin S

References

[1] wiener jj, sun s, thurmond rl. recent advances in the design of cathepsin s inhibitors. curr top med chem. 2010;10(7):717-32.
[2] lee-dutra a, wiener dk, sun s. cathepsin s inhibitors: 2004-2010. expert opin ther pat. 2011;21(3):311-37.

Z-FL-COCHO Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-FL-COCHO Suppliers

China 65 India 1 United Kingdom 1 United States 11 Global 78
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4768
Advantage
55
Olix (Shanghai) Pharmaceutical Technology Co., Ltd
Tel
17316404525 17316404525
Email
209533805@qq.com
Country
China
ProdList
9765
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
EnliPharma Technology Co., Ltd
Tel
0551-66399836 18955197623
Email
sales@enlipharma.com
Country
China
ProdList
1876
Advantage
55
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7778
Advantage
56
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
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View Lastest Price from Z-FL-COCHO manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Cathepsin S inhibitor 1373215-15-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Cathepsin S inhibitor 1373215-15-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

1373215-15-6, Z-FL-COCHORelated Search:


  • Z-FL-COCHO
  • ((3R,4S)-4-((4-FLUOROBENZOYL)AMINO)-6-(4-(OXETAN-3-YL)PIPERAZIN-1-YL)CHROMAN-3-YL)N-METHYLCARBAMATE
  • CATHEPSIN S INHIBITOR
  • CATHEPSIN S INHIBITOR ;LY-3000328;LY3000328
  • N-[(3R,4S)-3,4-Dihydro-3-[[(methylamino)carbonyl]oxy]-6-[4-(3-oxetanyl)-1-piperazinyl]-2H-1-benzopyran-4-yl]-4-fluorobenzamide
  • LY 3000328
  • Benzamide, N-[(3R,4S)-3,4-dihydro-3-[[(methylamino)carbonyl]oxy]-6-[4-(3-oxetanyl)-1-piperazinyl]-2H-1-benzopyran-4-yl]-4-fluoro-
  • (3R,4S)-4-(4-fluorobenzamido)-6-(4-(oxetan-3-yl)piperazin-1-yl)chroman-3-yl methylcarbamate
  • LY3000328，Cathepsin S inhibitor
  • Cathepsin,LY3000328,LY 3000328,Inhibitor,LY-3000328,inhibit
  • LY 3000328, 10 mM in DMSO
  • 1373215-15-6
  • C25H29FN4O5