Z-FL-COCHO
- Product Name
- Z-FL-COCHO
- CAS No.
- 1373215-15-6
- Chemical Name
- Z-FL-COCHO
- Synonyms
- LY 3000328;Z-FL-COCHO;CATHEPSIN S INHIBITOR;LY 3000328, 10 mM in DMSO;LY3000328，Cathepsin S inhibitor;CATHEPSIN S INHIBITOR ;LY-3000328;LY3000328;Cathepsin,LY3000328,LY 3000328,Inhibitor,LY-3000328,inhibit;(3R,4S)-4-(4-fluorobenzamido)-6-(4-(oxetan-3-yl)piperazin-1-yl)chroman-3-yl methylcarbamate;((3R,4S)-4-((4-FLUOROBENZOYL)AMINO)-6-(4-(OXETAN-3-YL)PIPERAZIN-1-YL)CHROMAN-3-YL)N-METHYLCARBAMATE;N-[(3R,4S)-3,4-Dihydro-3-[[(methylamino)carbonyl]oxy]-6-[4-(3-oxetanyl)-1-piperazinyl]-2H-1-benzopyran-4-yl]-4-fluorobenzamide
- CBNumber
- CB5175767
- Molecular Formula
- C25H29FN4O5
- Formula Weight
- 484.52
- MOL File
- Mol file
Z-FL-COCHO Property
- Boiling point:
- 701.6±60.0 °C(Predicted)
- Density
- 1.38±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥24.25 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
- form
- Powder
- pka
- 12.50±0.46(Predicted)
- color
- White to off-white
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 29729
- Product name
- LY3000328
- Packaging
- 500μg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 29729
- Product name
- LY3000328
- Packaging
- 10mg
- Price
- $632
- Updated
- 2024/03/01
- Product number
- 29729
- Product name
- LY3000328
- Packaging
- 1mg
- Price
- $152
- Updated
- 2024/03/01
- Product number
- 29729
- Product name
- LY3000328
- Packaging
- 5mg
- Price
- $356
- Updated
- 2024/03/01
- Product number
- L468955
- Product name
- LY3000328
- Packaging
- 2.5mg
- Price
- $525
- Updated
- 2021/12/16
Z-FL-COCHO Chemical Properties,Usage,Production
Description
LY3000328 is a potent cathepsin S inhibitor (IC50 = 7.7 nM for the human enzyme). It is selective for cathepsin S over cathepsin L, K, B, and V (IC50s = >10,000, >10,000, 4,390, and 21,500 nM, respectively). LY3000328 (1-30 mg/kg) reduces aortic diameter in a mouse model of calcium chloride-induced abdominal aortic aneurysm.
Uses
LY 3000328 is a cathepsin S inhibitor for treatment of abdominal aortic aneurysm. Further provides methods for treating plaque instability, atherosclerosis, or autoimmune disorders such as rheumatoid arthritis, psoriasis, and lupus comprising administering a therapeutically effective amount of a disclosed compound.
target
cathepsin S
References
[1] wiener jj, sun s, thurmond rl. recent advances in the design of cathepsin s inhibitors. curr top med chem. 2010;10(7):717-32.
[2] lee-dutra a, wiener dk, sun s. cathepsin s inhibitors: 2004-2010. expert opin ther pat. 2011;21(3):311-37.
Z-FL-COCHO Preparation Products And Raw materials
Raw materials
Preparation Products
Z-FL-COCHO Suppliers
- Tel
- --
- Fax
- --
- solutions@vwr.com
- Country
- United Kingdom
- ProdList
- 6548
- Advantage
- 82
View Lastest Price from Z-FL-COCHO manufacturers
- Product
- Cathepsin S inhibitor 1373215-15-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Cathepsin S inhibitor 1373215-15-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09