N-BUTYL-2-CHLORO-ACETAMIDE
- Product Name
- N-BUTYL-2-CHLORO-ACETAMIDE
- CAS No.
- 5349-24-6
- Chemical Name
- N-BUTYL-2-CHLORO-ACETAMIDE
- Synonyms
- TIMTEC-BB SBB010319;N-BUTYL-2-CHLORACETAMIDE;ASINEX-REAG BAS 02927056;N-BUTYL-2-CHLORO-ACETAMIDE;N-butyl-2-chloro-ethanamide;Acetamide, N-butyl-2-chloro-
- CBNumber
- CB5177802
- Molecular Formula
- C6H12ClNO
- Formula Weight
- 149.62
- MOL File
- 5349-24-6.mol
N-BUTYL-2-CHLORO-ACETAMIDE Property
- Melting point:
- 96.5 °C(Solv: benzene (71-43-2))
- Boiling point:
- 110 °C(Press: 7.0 Torr)
- Density
- 1.032±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 14.38±0.46(Predicted)
- Appearance
- Colorless to light yellow Liquid
N-Bromosuccinimide Price
- Product number
- 018561
- Product name
- N-Butyl-2-chloro-acetamide
- Packaging
- 500mg
- Price
- $182
- Updated
- 2021/12/16
- Product number
- HCH0026847
- Product name
- N-BUTYL-2-CHLORO-ACETAMIDE
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $777.32
- Updated
- 2021/12/16
- Product number
- W6790
- Product name
- N-Butyl-2-chloro-acetamide
- Packaging
- 25g
- Price
- $847
- Updated
- 2021/12/16
- Product number
- A225554
- Product name
- N-Butyl-2-chloroacetamide
- Purity
- 97%
- Packaging
- 250mg
- Price
- $26
- Updated
- 2021/12/16
- Product number
- A225554
- Product name
- N-Butyl-2-chloroacetamide
- Purity
- 97%
- Packaging
- 1g
- Price
- $64
- Updated
- 2021/12/16
N-BUTYL-2-CHLORO-ACETAMIDE Chemical Properties,Usage,Production
Synthesis
109-73-9
79-04-9
5349-24-6
GENERAL STEPS: Chloroacetyl chloride (0.2 mol, 15.9 mL, CAS: 79-04-9) was slowly added dropwise to a solution of dichloromethane (50 mL) containing n-butylamine (0.2 mol, 14.83 g) in an ice bath. After the dropwise addition, 20% NaOH aqueous solution was added and the reaction mixture was warmed up to room temperature and stirring was continued for 2 hours. After completion of the reaction, the organic phase was separated and washed sequentially with 5% aqueous HCl and 5% aqueous NaHCO3 (3 x 25 mL each). The organic phase was dried and filtered, and then the solvent was removed by distillation under reduced pressure to give the intermediate N-butyl-2-chloroacetamide (92% yield). Subsequently, the intermediate (0.05 mol, 9.00 g) was mixed with 5,6,7,8-tetrahydropyrido[1,2-α]imidazole (0.05 mol, 6.11 g, CAS: 34167-66-3) in acetonitrile (50 mL) and the reaction was carried out at reflux for 18 hours. The reaction solution was recrystallized by ethyl acetate recrystallization operation to give the product [4C-imCH2CONHBu]Cl (89% yield). Finally, [4C-imCH2CONHBu]OH was obtained by treatment with anion exchange resin.
References
[1] Patent: CN104326949, 2016, B. Location in patent: Paragraph 0060; 0061; 0063
[2] Patent: WO2007/9083, 2007, A2. Location in patent: Page/Page column 68
[3] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 6, p. 678 - 681
[4] ChemMedChem, 2018,
[5] Organic Letters, 2004, vol. 6, # 26, p. 4805 - 4808
N-BUTYL-2-CHLORO-ACETAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
N-BUTYL-2-CHLORO-ACETAMIDE Suppliers
- Tel
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- Fax
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- sales@ajchem.in
- Country
- India
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- 6100
- Advantage
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View Lastest Price from N-BUTYL-2-CHLORO-ACETAMIDE manufacturers
- Product
- N-BUTYL-2-CHLORO-ACETAMIDE 5349-24-6
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-09