6-(2,2,2-trifluoroethoxy)pyridin-3-amine
- Product Name
- 6-(2,2,2-trifluoroethoxy)pyridin-3-amine
- CAS No.
- 72617-82-4
- Chemical Name
- 6-(2,2,2-trifluoroethoxy)pyridin-3-amine
- Synonyms
- 6-(2,2,2-Trifluoroethoxy);6-(2,2,2-Trifluoroethoxy)-3-pyridinaMine;6-(2,2,2-trifluoroethoxy)pyridin-3-amine;3-Pyridinamine, 6-(2,2,2-trifluoroethoxy)-
- CBNumber
- CB51780683
- Molecular Formula
- C7H7F3N2O
- Formula Weight
- 192.14
- MOL File
- 72617-82-4.mol
6-(2,2,2-trifluoroethoxy)pyridin-3-amine Property
- Boiling point:
- 247.9±40.0 °C(Predicted)
- Density
- 1.354±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 3.70±0.22(Predicted)
- Appearance
- Light yellow to brown Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B588088
- Product name
- 6-(2,2,2-trifluoroethoxy)pyridin-3-amine
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- PC201293
- Product name
- 6-(2,2,2-Trifluoroethoxy)pyridin-3-amine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $57
- Updated
- 2021/12/16
- Product number
- W8120
- Product name
- 6-(2,2,2-Trifluoroethoxy)pyridin-3-amine
- Packaging
- 250mg
- Price
- $124
- Updated
- 2021/12/16
- Product number
- 4H30-3-11
- Product name
- 6-(2,2,2-Trifluoroethoxy)pyridin-3-amine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- 4H30-3-11
- Product name
- 6-(2,2,2-Trifluoroethoxy)pyridin-3-amine
- Purity
- 97%
- Packaging
- 1g
- Price
- $395
- Updated
- 2021/12/16
6-(2,2,2-trifluoroethoxy)pyridin-3-amine Chemical Properties,Usage,Production
Synthesis
72617-81-3
72617-82-4
Step 2: Synthesis of 6-(2,2,2-trifluoroethoxy)-3-pyridinamine 5-Nitro-2-(2,2,2-trifluoroethoxy)pyridine (20.5 g, obtained from Example 108 Step 1) was dissolved in methanol (160 mL). Palladium/activated carbon catalyst (1.96 g, 10% Pd) was added to the solution and hydrogen was passed through at room temperature. The reaction mixture was stirred under hydrogen atmosphere for 72 hours. Upon completion of the reaction, the reaction mixture was filtered using Dicalite Speed Plus (Acros Organics) and the filter cake was washed with ethyl acetate. The filtrate was concentrated under reduced pressure to remove the solvent. The resulting residue was purified by fast column chromatography (silica gel as stationary phase, heptane/ethyl acetate gradient elution) to afford 6-(2,2,2-trifluoroethoxy)-3-pyridinamine as a brown liquid (16.49 g, 91% yield). Mass spectrometry (MS) data: m/e 193.1 [MH+].
References
[1] Patent: WO2011/45292, 2011, A1. Location in patent: Page/Page column 176
[2] Patent: US2011/92512, 2011, A1. Location in patent: Page/Page column 55
[3] Patent: US2004/63738, 2004, A1
[4] Patent: JP2015/86180, 2015, A. Location in patent: Paragraph 0040
6-(2,2,2-trifluoroethoxy)pyridin-3-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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