4-(4-NITROBENZYL)MORPHOLINE
- Product Name
- 4-(4-NITROBENZYL)MORPHOLINE
- CAS No.
- 6425-46-3
- Chemical Name
- 4-(4-NITROBENZYL)MORPHOLINE
- Synonyms
- BUTTPARK 96\57-67;4-(4-NITROBENZYL)MORPHOLINE;4-(4-Nitrobenzyl)morpholine,97%;4-(4-NITROBENZYL)MORPHOLINE 95%;4-[(4-nitrophenyl)Methyl]Morpholine;Morpholine, 4-[(4-nitrophenyl)Methyl]-;4-[(4-nitrophenyl)methyl]morpholin-4-ium
- CBNumber
- CB5178218
- Molecular Formula
- C11H14N2O3
- Formula Weight
- 222.24
- MOL File
- 6425-46-3.mol
4-(4-NITROBENZYL)MORPHOLINE Property
- Melting point:
- 79.6-80 °C
- Boiling point:
- 349.4±27.0 °C(Predicted)
- Density
- 1.243±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 5.82±0.10(Predicted)
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 36/37/39-26-22
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 071887
- Product name
- 4-(4-Nitrobenzyl)morpholine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- W7600
- Product name
- 4-(4-Nitrobenzyl)morpholine
- Packaging
- 1g
- Price
- $71
- Updated
- 2021/12/16
- Product number
- OR110998
- Product name
- 4-(4-Nitrobenzyl)morpholine
- Packaging
- 1g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 4H54-1-9Z
- Product name
- 4-(4-Nitrobenzyl)morpholine
- Packaging
- 1g
- Price
- $104
- Updated
- 2021/12/16
- Product number
- OR110998
- Product name
- 4-(4-Nitrobenzyl)morpholine
- Packaging
- 5g
- Price
- $145
- Updated
- 2021/12/16
4-(4-NITROBENZYL)MORPHOLINE Chemical Properties,Usage,Production
Chemical Properties
yellow-orange to orange crystalline powder
Synthesis
110-91-8
100-11-8
6425-46-3
General steps: 1. 4-Nitrobenzyl bromide (72.084 g) and dichloromethane (470 mL, dried over molecular sieves) were added to a reaction flask under argon protection and stirred until completely dissolved. 2. Anhydrous potassium carbonate (91.909 g) was added as a base. 3. The reaction mixture was cooled in an ice bath for 20 minutes. 4. Slowly add morpholine dropwise (completion of dropwise addition in about 30 minutes). 5. After completion of the dropwise addition, the ice bath was removed and the reaction mixture was stirred at room temperature overnight. 6. Upon completion of the reaction, the reaction was quenched by the addition of water (150 mL). 7. The pH of the reaction mixture was adjusted to 4-5 with 5% aqueous citric acid. 8. After standing and layering, the organic phase was separated and washed once with deionized water (260 mL). 9. The organic phase was dried with anhydrous magnesium sulfate for 30 minutes, followed by filtration. 10. The filtrate was concentrated and dried under reduced pressure by an oil pump to afford 4-(4-nitrobenzyl)morpholine (71.9 g, 97.16% yield).
References
[1] Journal of Medicinal Chemistry, 2013, vol. 56, # 7, p. 2975 - 2990
[2] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2010, vol. 49, # 6, p. 771 - 775
[3] Patent: EP2824108, 2015, A1. Location in patent: Paragraph 0101
[4] Patent: US2015/166595, 2015, A1. Location in patent: Paragraph 0219
[5] Patent: CN106432235, 2017, A. Location in patent: Paragraph 0089; 0090
4-(4-NITROBENZYL)MORPHOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(4-NITROBENZYL)MORPHOLINE manufacturers
- Product
- 4-(4-NITROBENZYL)MORPHOLINE 6425-46-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 10t
- Release date
- 2019-12-20