5-Benzylidenehydantoin
- Product Name
- 5-Benzylidenehydantoin
- CAS No.
- 3775-01-7
- Chemical Name
- 5-Benzylidenehydantoin
- Synonyms
- RARECHEM AP KH 0029;TIMTEC-BB SBB007867;Benzylidene hydantoin;5-Benzylidendhydantoin;5-BENZYLIDENEHYDANTOIN;5-phenylmethylenehydantoin;5-Benzylideneimidazolidine-2,4-dione;5-Benzylidene-2,4-imidazolidinedione;(5E)-5-Benzylidene-2,4-imidazolidinedione;2,4-Imidazolidinedione, 5-(phenylmethylene)-
- CBNumber
- CB5179770
- Molecular Formula
- C10H8N2O2
- Formula Weight
- 188.18
- MOL File
- 3775-01-7.mol
5-Benzylidenehydantoin Property
- Melting point:
- 220.00°C - 222.00°C
- Density
- 1.329g/cm3
- InChI
- InChI=1S/C10H8N2O2/c13-9-8(11-10(14)12-9)6-7-4-2-1-3-5-7/h1-6H,(H2,11,12,13,14)
- InChIKey
- UDTSPKADQGPZFS-UHFFFAOYSA-N
- SMILES
- C1(=O)NC(=CC2=CC=CC=C2)C(=O)N1
N-Bromosuccinimide Price
- Product number
- FB149856
- Product name
- 5-Benzylidenehydantoin
- Packaging
- 25g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 172046
- Product name
- 5-Benzylidenehydantoin
- Packaging
- 5g
- Price
- $118
- Updated
- 2021/12/16
- Product number
- FB149856
- Product name
- 5-Benzylidenehydantoin
- Packaging
- 50g
- Price
- $166
- Updated
- 2021/12/16
- Product number
- FB149856
- Product name
- 5-Benzylidenehydantoin
- Packaging
- 100g
- Price
- $288
- Updated
- 2021/12/16
- Product number
- 172046
- Product name
- 5-Benzylidenehydantoin
- Packaging
- 25g
- Price
- $370
- Updated
- 2021/12/16
5-Benzylidenehydantoin Chemical Properties,Usage,Production
Description
Derivatives of 5-Benzylidenehydantoin are well known of their various attractive bioactivities such as anticancer, antimicrobial, antidiabetic and tyrosinase inhibitor. UPR1024 belongs to a new class of EGFR inhibitors characterized by a hydantoin nucleus and a 5-benzylidene substituent having a double bond conjugated with a carbonyl group on the hydantoin ring. The compound had antiproliferative and proapoptotic effects when tested on the non-small cell lung cancer cell line A549[1-2].
Biological Activity
5-Benzylidenehydantoins inhibited the EGFR kinase and exhibited an antiproliferative action on A431 human epidermoid carcinoma cells. The conjugated exo-cyclic double bond at the C5 position appeared essential for both EGFR and cell growth inhibition, indicating that the 5-benzylidene hydantoin core would be a suitable scaffold for generating new antiproliferative compounds[3].
References
[1] Haq, K. U. et al. “Synthesis of 5-benzylidene-hydantoin and 5-benzylidene-creatinine derivatives under mixed catalyst systems of urea-p-toluenesulfonic acid (Urea-PTSA) and guanidine hydrochloride-triethylamine (GnHCl-TEA).”(2020).
[2] Andrea Cavazzoni. “Dual mechanisms of action of the 5-benzylidene-hydantoin UPR1024 on lung cancer cell lines.” Molecular Cancer Therapeutics 7 2 (2008): 361–70.
5-Benzylidenehydantoin Preparation Products And Raw materials
Raw materials
Preparation Products
5-Benzylidenehydantoin Suppliers
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View Lastest Price from 5-Benzylidenehydantoin manufacturers
- Product
- 5-Benzylidene Hydantoin 3775-01-7
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 99%
- Supply Ability
- 2000
- Release date
- 2024-05-27
- Product
- 5-Benzylidene Hydantoin 3775-01-7
- Price
- US $0.00/kg
- Min. Order
- 20kg
- Purity
- 99%
- Supply Ability
- 2000mt
- Release date
- 2024-06-27
- Product
- 5-Benzylidenehydantoin 3775-01-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20t
- Release date
- 2024-07-14