5-Benzylidenehydantoin

Product Name: 5-Benzylidenehydantoin
CAS No.: 3775-01-7
Chemical Name: 5-Benzylidenehydantoin
Synonyms: RARECHEM AP KH 0029;TIMTEC-BB SBB007867;Benzylidene hydantoin;5-Benzylidendhydantoin;5-BENZYLIDENEHYDANTOIN;5-phenylmethylenehydantoin;5-Benzylideneimidazolidine-2,4-dione;5-Benzylidene-2,4-imidazolidinedione;(5E)-5-Benzylidene-2,4-imidazolidinedione;2,4-Imidazolidinedione, 5-(phenylmethylene)-
CBNumber: CB5179770
Molecular Formula: C10H8N2O2
Formula Weight: 188.18
MOL File: 3775-01-7.mol

More

Less

5-Benzylidenehydantoin Property

Melting point:: 220.00°C - 222.00°C
Density: 1.329g/cm3
InChI: InChI=1S/C10H8N2O2/c13-9-8(11-10(14)12-9)6-7-4-2-1-3-5-7/h1-6H,(H2,11,12,13,14)
InChIKey: UDTSPKADQGPZFS-UHFFFAOYSA-N
SMILES: C1(=O)NC(=CC2=CC=CC=C2)C(=O)N1

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FB149856
Product name: 5-Benzylidenehydantoin
Packaging: 25g
Price: $95
Updated: 2021/12/16

Matrix Scientific

Product number: 172046
Product name: 5-Benzylidenehydantoin
Packaging: 5g
Price: $118
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB149856
Product name: 5-Benzylidenehydantoin
Packaging: 50g
Price: $166
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB149856
Product name: 5-Benzylidenehydantoin
Packaging: 100g
Price: $288
Updated: 2021/12/16

Matrix Scientific

Product number: 172046
Product name: 5-Benzylidenehydantoin
Packaging: 25g
Price: $370
Updated: 2021/12/16

More

Less

5-Benzylidenehydantoin Chemical Properties,Usage,Production

Description

Derivatives of 5-Benzylidenehydantoin are well known of their various attractive bioactivities such as anticancer, antimicrobial, antidiabetic and tyrosinase inhibitor. UPR1024 belongs to a new class of EGFR inhibitors characterized by a hydantoin nucleus and a 5-benzylidene substituent having a double bond conjugated with a carbonyl group on the hydantoin ring. The compound had antiproliferative and proapoptotic effects when tested on the non-small cell lung cancer cell line A549[1-2].

Biological Activity

5-Benzylidenehydantoins inhibited the EGFR kinase and exhibited an antiproliferative action on A431 human epidermoid carcinoma cells. The conjugated exo-cyclic double bond at the C5 position appeared essential for both EGFR and cell growth inhibition, indicating that the 5-benzylidene hydantoin core would be a suitable scaffold for generating new antiproliferative compounds[3].

References

[1] Haq, K. U. et al. “Synthesis of 5-benzylidene-hydantoin and 5-benzylidene-creatinine derivatives under mixed catalyst systems of urea-p-toluenesulfonic acid (Urea-PTSA) and guanidine hydrochloride-triethylamine (GnHCl-TEA).”(2020).
[2] Andrea Cavazzoni. “Dual mechanisms of action of the 5-benzylidene-hydantoin UPR1024 on lung cancer cell lines.” Molecular Cancer Therapeutics 7 2 (2008): 361–70.

5-Benzylidenehydantoin Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

5-Benzylidenehydantoin Suppliers

China 25 Germany 2 United Kingdom 3 United States 7 Global 37

SHIJIAZHUANG DONGHUA JINLONG CHEMICAL CO.,LTD.

Tel: 0311-66619688 15632114516
Email: donghuajinlong@glycine.com.cn
Country: China
ProdList: 11
Advantage: 58

Yantai ShengKailun Chemical Technology Co., Ltd.

Tel: 13356901049
Fax: QQ：1025383091
Email: 3119594100@qq.com
Country: China
ProdList: 7964
Advantage: 55

Beijing Hihealth Pharma. Sci. & Tech. Co.,Ltd.

Tel: 13911823113
Email: hihealth@sina.com
Country: China
ProdList: 59
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28172
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-029-81138252 +86-18789408387
Fax: 029-88380327
Email: 1057@dideu.com
Country: China
ProdList: 3959
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-29-81148696 +86-15536356810
Email: 1022@dideu.com
Country: China
ProdList: 3882
Advantage: 58

Shandong WorldSun Biological Technology Co., Ltd.

Tel: 0531-88723173 18596073690
Email: 1047208234@qq.com
Country: China
ProdList: 4682
Advantage: 58

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-59207852 13308628970
Fax: QQ:2779667926
Email: buy@fortunachem.com
Country: China
ProdList: 2792
Advantage: 58

Wuhan Yuqing Jiaheng Pharmaceutical Co., Ltd.

Tel: 027-83850122 13343472658
Email: 918571372@qq.com
Country: China
ProdList: 2078
Advantage: 58

TCI (Shanghai) Chemical Trading Co., Ltd.

Tel: 021-021-61109150
Fax: 021-61105897
Email: sales@tcisct.com
Country: China
ProdList: 31121
Advantage: 58

Yantai Sheng Kai Lun Biological Products Co. , Ltd.

Tel: 13356901049
Email: mark@sklnchem.cn
Country: China
ProdList: 14384
Advantage: 58

Shaanxi Xihua Chemical Industry Co., Ltd

Tel: 17691182729 15529505138
Email: 1021@dideu.com
Country: China
ProdList: 9972
Advantage: 58

shanghai yayu biomedical co.,ltd

Tel: 021-54370211 18051886391
Email: 3007215920@qq.com
Country: China
ProdList: 2989
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: rose.shi@synzest.com
Country: China
ProdList: 6210
Advantage: 58

HUBEI CHANGYAO BIOTECHNOLOGY CO LTD

Tel: 17683887209
Email: 906856569@qq.com
Country: China
ProdList: 4973
Advantage: 58

JIANGSU BSECHEM CHEMICAL TECHNOLOGY Co., Ltd

Tel: 15651337098
Email: 15651337098@163.com
Country: China
ProdList: 4415
Advantage: 58

Hangzhou FandaChem Co.,Ltd.

Tel: +8615858145714
Fax: +86-571-56059825
Email: FandaChem@Gmail.com
Country: China
ProdList: 9087
Advantage: 55

Guangzhou CATO Research Chemicals Inc.

Tel: +86-020-81960175-617 +8615602392859
Email: Intermediate@cato-chem.com
Country: China
ProdList: 8047
Advantage: 58

Shijiazhuang Donghua Jinlong Chemical Co., LTD

Tel: +86-031166619888 +86-19333738986
Email: donghuajinlong@glycine.com.cn
Country: China
ProdList: 25
Advantage: 58

Kindchem(Nanjing)Co.,Ltd

Tel: +86-025-025-85281586 +8618651653755
Fax: 025-68661290
Email: sales@kindchem.cn
Country: China
ProdList: 1226
Advantage: 58

Shenyang longbang international Trading Co.Ltd

Tel: --
Fax: --
Email: chemexper@163.com
Country: China
ProdList: 1689
Advantage: 30

Shanghai PI Chemicals Ltd.

Tel: --
Fax: --
Email: sales@pipharm.com
Country: China
ProdList: 6344
Advantage: 56

Rudong physical and chemical plants

Tel: --
Fax: --
Email: sales@frinton.com
Country: China
ProdList: 4687
Advantage: 80

Advanced Technology & Industrial Co., Ltd.

Tel: --
Fax: --
Email: sales@advtechind.com
Country: China
ProdList: 6523
Advantage: 75

Xiamen Flint Chemical Co., Ltd

Tel: --
Fax: --
Email: sales@flintchem.com
Country: China
ProdList: 6589
Advantage: 65

More

Less

View Lastest Price from 5-Benzylidenehydantoin manufacturers

Shijiazhuang Donghua Jinlong Chemical Co., LTD

Product: 5-Benzylidene Hydantoin 3775-01-7
Price: US $0.00/kg
Min. Order: 25kg
Purity: 99%
Supply Ability: 2000
Release date: 2024-05-27

Shijiazhuang Donghua Jinlong Chemical Co., LTD

Product: 5-Benzylidene Hydantoin 3775-01-7
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 2000mt
Release date: 2024-06-27

Shaanxi Dideu Medichem Co. Ltd

Product: 5-Benzylidenehydantoin 3775-01-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20t
Release date: 2024-07-14

3775-01-7, 5-BenzylidenehydantoinRelated Search:

Hydantoin 5-(3'-HYDROXYBENZYLIDENE)HYDANTOIN 4-[(2,5-DIOXOTETRAHYDRO-1H-IMIDAZOL-4-YLIDEN)METHYL]PHENYL 3-CHLORO-2,2-DIMETHYLPROPANOATE 4-CHLOROBENZALHYDANTOIN 5-((4-ETHOXYPHENYL)METHYLENE)IMIDAZOLIDINE-2,4-DIONE (5E)-5-(3-BROMO-5-ETHOXY-4-HYDROXYBENZYLIDENE)-3-ETHYLIMIDAZOLIDINE-2,4-DIONE LABOTEST-BB LT00020977 (5E)-3-BENZYL-5-(3-CHLORO-4,5-DIMETHOXYBENZYLIDENE)IMIDAZOLIDINE-2,4-DIONE CHEMBRDG-BB 6478345 1-IMIDAZOLIDINEACETIC ACID, 4-((4-CHLOROPHENYL)METHYLENE)-2,5-DIOXO- 2,4-IMIDAZOLIDINEDIONE, 3-METHYL-5-((4-METHYLPHENYL)METHYLENE)- SALOR-INT L260584-1EA 3-ACETYL-5-(3-ACETOXYBENZAL)-HYDANTOIN 5-BENZYLIDENEHYDANTOIN

(5E)-5-Benzylidene-2,4-imidazolidinedione

2,4-Imidazolidinedione, 5-(phenylmethylene)-

5-phenylmethylenehydantoin

TIMTEC-BB SBB007867

RARECHEM AP KH 0029

Benzylidene hydantoin

5-Benzylidendhydantoin

5-BENZYLIDENEHYDANTOIN ---YELLOWISH POWDER---

5-Benzylidene-2,4-imidazolidinedione

5-Benzylideneimidazolidine-2,4-dione

5-BENZYLIDENEHYDANTOIN

3775-01-7

684-83-8