METHIOTHEPIN MALEATE
- Product Name
- METHIOTHEPIN MALEATE
- CAS No.
- 20229-30-5
- Chemical Name
- METHIOTHEPIN MALEATE
- Synonyms
- RO 8-6837;Metitepine;methiothepin;Methiothepine;METITEPINE MESYLATE;METHIOTHEPIN MALEATE;METHIOTHEPIN MESYLATE;8-Methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepine;(+-)-8-methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin;dibenzo(b,f)thiepin,10,11-dihydro-10-(4-methylpiperazinyl)-8-(methylthio)-(
- CBNumber
- CB5181681
- Molecular Formula
- C20H24N2S2
- Formula Weight
- 356.55
- MOL File
- 20229-30-5.mol
METHIOTHEPIN MALEATE Property
- Melting point:
- 88-89°
- Boiling point:
- 462.9±45.0 °C(Predicted)
- Density
- 1.25±0.1 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- H2O: 13 mg/mL
- form
- solid
- pka
- 7.95±0.42(Predicted)
- color
- white
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 255796
- Product name
- Methiothepin maleate
- Packaging
- 50mg
- Price
- $339
- Updated
- 2021/12/16
- Product number
- API0015806
- Product name
- METHIOTHEPIN
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $624.57
- Updated
- 2021/12/16
METHIOTHEPIN MALEATE Chemical Properties,Usage,Production
Uses
5HT1&2 receptor antagonist
Uses
Methiothepin Maleate exhibits anticonvulsant property and it is able to suppress pentylenetetrazol induced fos expression in zebrafish. In addition, Methiothepin Maleate is a 5-HT antagonist.
Definition
ChEBI: Methiothepin is a dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively). It has a role as an antipsychotic agent, a dopaminergic antagonist, a serotonergic antagonist and a geroprotector. It is a N-alkylpiperazine, a dibenzothiepine, an aryl sulfide and a tertiary amino compound. It is a conjugate base of a methiothepin(2+).
Biological Activity
Potent 5-HT 2 antagonist, also active as 5-HT 1 antagonist. Differentiates 5-HT 1D sub-types. Also displays affinity for rodent 5-HT 5B , 5-HT 5A , 5-HT 7 and 5-HT 6 receptors (pK 1 values are 6.6, 7.0, 8.4 and 8.7 respectively).
METHIOTHEPIN MALEATE Preparation Products And Raw materials
Raw materials
Preparation Products
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