ChemicalBook > CAS DataBase List > (-)-LEUKOTRIENE A4 METHYL ESTER

(-)-LEUKOTRIENE A4 METHYL ESTER

Product Name
(-)-LEUKOTRIENE A4 METHYL ESTER
CAS No.
73466-12-3
Chemical Name
(-)-LEUKOTRIENE A4 METHYL ESTER
Synonyms
(-)-leukotriene A4;PWXYNAKNLZUYAL-WAQVJNLQSA-N;LEUKOTRIENE A4 METHYL ESTER;(-)-LEUKOTRIENE A4 METHYL ESTER;LTA4 (Leukotriene A4 methyl ester);5S-TRANS-5,6-OXIDO-7E,9E,11Z,14Z-EICOSATETRAENOIC ACID, METHYL ESTER;LEUKOTRIENE A4-METHYLESTER SOLUTION (100UG/ML HEXANE/1% TRIETHYLAMINE);2-Oxiranebutanoic acid, 3-(1E,3E,5Z,8Z)-1,3,5,8-tetradecatetraen-1-yl-, methyl ester, (2S,3S)-
CBNumber
CB5184743
Molecular Formula
C21H32O3
Formula Weight
332.48
MOL File
73466-12-3.mol
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(-)-LEUKOTRIENE A4 METHYL ESTER Property

storage temp. 
−20°C
solubility 
Acetone: >50 mg/ml; DMF: >50 mg/ml; DMSO: >50 mg/ml; Ethanol: >50 mg/ml; PBS pH 7.2: insoluble and unstable.
form 
triethylamine:hexane solution
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Safety

Hazard Codes 
F,Xn,N
Risk Statements 
11-36/37/38-48/20-51/53-62-65-67
Safety Statements 
9-16-29-33-36/37-61-62
RIDADR 
UN 1208 3/PG 2
WGK Germany 
2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H304May be fatal if swallowed and enters airways

H315Causes skin irritation

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

H361Suspected of damaging fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P331Do NOT induce vomiting.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P391Collect spillage. Hazardous to the aquatic environment

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20010
Product name
Leukotriene A4 methyl ester
Purity
≥97%
Packaging
25μg
Price
$144
Updated
2024/03/01
Cayman Chemical
Product number
20010
Product name
Leukotriene A4 methyl ester
Purity
≥97%
Packaging
50μg
Price
$274
Updated
2024/03/01
Cayman Chemical
Product number
20010
Product name
Leukotriene A4 methyl ester
Purity
≥97%
Packaging
100μg
Price
$519
Updated
2024/03/01
Cayman Chemical
Product number
20010
Product name
Leukotriene A4 methyl ester
Purity
≥97%
Packaging
500μg
Price
$1579
Updated
2023/06/20
Usbiological
Product number
366268
Product name
Leukotriene A4
Packaging
96Tests
Price
$938
Updated
2021/12/16
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(-)-LEUKOTRIENE A4 METHYL ESTER Chemical Properties,Usage,Production

Description

Leukotriene A4 (LTA4) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities. LTA4 is rapidly metabolized by LTA4 hydrolase or LTC4 synthase to LTB4 or LTC4, respectively. LTA4, from leukocytes, is known to undergo transcellular metabolism in platelets, erythrocytes, and endothelial cells. Further metabolism of LTA4 by 15-LO leads to lipoxin biosynthesis. LTA4 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.

Uses

LTA4 (Leukotriene A4 methyl ester) is an unstable intermediate in the biosynthesis of LTB4 and LTC4.

(-)-LEUKOTRIENE A4 METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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(-)-LEUKOTRIENE A4 METHYL ESTER Suppliers

China 14 Europe 2 France 1 Germany 2 Japan 1 Switzerland 2 Ukraine 1 United Kingdom 1 United States 9 Global 33
Alfa Chemistry
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Alfa Chemistry
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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TargetMol Chemicals Inc.
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Aladdin Scientific
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73466-12-3, (-)-LEUKOTRIENE A4 METHYL ESTERRelated Search:

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  • (-)-LEUKOTRIENE A4 METHYL ESTER
  • LEUKOTRIENE A4 METHYL ESTER
  • (-)-leukotriene A4
  • LEUKOTRIENE A4-METHYLESTER SOLUTION (100UG/ML HEXANE/1% TRIETHYLAMINE)
  • LTA4 (Leukotriene A4 methyl ester)
  • PWXYNAKNLZUYAL-WAQVJNLQSA-N
  • 5S-TRANS-5,6-OXIDO-7E,9E,11Z,14Z-EICOSATETRAENOIC ACID, METHYL ESTER
  • 2-Oxiranebutanoic acid, 3-(1E,3E,5Z,8Z)-1,3,5,8-tetradecatetraen-1-yl-, methyl ester, (2S,3S)-
  • 73466-12-3
  • Biochemicals and Reagents
  • BioChemical
  • Unsaturated fatty acids and derivatives
  • Esters
  • Fatty Acids
  • Methyl Esters
  • Lipids