ChemicalBook > CAS DataBase List > 6-bromo-4-chlorothieno[3,2-d]pyrimidine
6-bromo-4-chlorothieno[3,2-d]pyrimidine
- Product Name
- 6-bromo-4-chlorothieno[3,2-d]pyrimidine
- CAS No.
- 225385-03-5
- Chemical Name
- 6-bromo-4-chlorothieno[3,2-d]pyrimidine
- Synonyms
- KML-23;CML-008;6-bromo-4-chlorothieno[3,2-d]pyrimidine;4-Chloro-6-bromothieno[3,2-d]pyrimidine;Thieno[3,2-d]pyrimidine,6-bromo-4-chloro-;6-broMo-4-chlorothieno[3,2-d]pyriMidine hcl;6-bromo-4-chlorothieno[3,2-d]pyrimidine ISO 9001：2015 REACH
- CBNumber
- CB51856160
- Molecular Formula
- C6H2BrClN2S
- Formula Weight
- 249.52
- MOL File
- 225385-03-5.mol
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6-bromo-4-chlorothieno[3,2-d]pyrimidine Property
- Boiling point:
- 345.5±37.0 °C(Predicted)
- Density
- 1.955
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- solid
- pka
- -0.19±0.40(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C6H2BrClN2S/c7-4-1-3-5(11-4)6(8)10-2-9-3/h1-2H
- InChIKey
- RJKAKJGOZXERRE-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=C2SC(Br)=CC2=N1
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SYX00387
- Product name
- 4-Chloro-6-bromothieno[3,2-d]pyrimidine
- Packaging
- 1g
- Price
- $330
- Updated
- 2025/07/31
TRC
- Product number
- B684893
- Product name
- 6-Bromo-4-chlorothieno[3,2-d]pyrimidine
- Packaging
- 25mg
- Price
- $50
- Updated
- 2021/12/16
TRC
- Product number
- B684893
- Product name
- 6-Bromo-4-chlorothieno[3,2-d]pyrimidine
- Packaging
- 50mg
- Price
- $70
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 059886
- Product name
- 6-Bromo-4-chlorothieno[3,2-d]pyrimidine
- Purity
- >95%
- Packaging
- 500mg
- Price
- $112
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 059886
- Product name
- 6-Bromo-4-chlorothieno[3,2-d]pyrimidine
- Purity
- >95%
- Packaging
- 1g
- Price
- $173
- Updated
- 2021/12/16
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6-bromo-4-chlorothieno[3,2-d]pyrimidine Chemical Properties,Usage,Production
Synthesis
16269-66-2
225385-03-5
General procedure for the synthesis of 6-bromo-4-chlorothieno[3,2-d]pyrimidines from 4-chlorothieno[3,2-d]pyrimidines: to dry 200 mL of tetrahydrofuran was added lithium diisopropylamine (25 mL, 61.54 mmol), and the reaction system was cooled to -78 °C. Subsequently, 4-chlorothieno[3,2-d] Pyrimidine (5 g, 39.30 mmol) was slowly added dropwise to the above mixture. After 20 min of reaction, 1,2-dibromo-1,1,2,2-tetrafluoroethane (11.45 g, 35.17 mmol) was slowly added. Stirring was continued at -78°C for 20 minutes, then gradually warmed to room temperature and continued for 2 hours. Upon completion of the reaction, water was added to the mixture and extracted with chloroform (3 x 300 mL), the organic phases were combined and dried over anhydrous magnesium sulfate. After concentration under reduced pressure, the mixture was developed with 200 mL of hexane to afford 6-bromo-4-chlorothieno[3,2-d]pyrimidine (6.5 g, 89.2% yield) as a dark brown solid. The product was characterized by 1H-NMR (400 MHz, CDCl3): δ 8.94 (s, 1H), 7.62 (s, 1H); LC-MS showed molecular ion peaks of 249 and 251 (MH+).
References
[1] MedChemComm, 2015, vol. 6, # 2, p. 339 - 346
[2] Journal of Medicinal Chemistry, 2015, vol. 58, # 14, p. 5522 - 5537
[3] Patent: US2013/72482, 2013, A1. Location in patent: Paragraph 0211; 0218; 0219
[4] Patent: US2007/99941, 2007, A1. Location in patent: Page/Page column 15
[5] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 1, p. 21 - 24
6-bromo-4-chlorothieno[3,2-d]pyrimidine Preparation Products And Raw materials
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Preparation Products
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View Lastest Price from 6-bromo-4-chlorothieno[3,2-d]pyrimidine manufacturers
Dideu Industries Group Limited
- Product
- 6-bromo-4-chlorothieno[3,2-d]pyrimidine 225385-03-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-01
Career Henan Chemical Co
- Product
- 6-bromo-4-chlorothieno[3,2-d]pyrimidine 225385-03-5
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08
225385-03-5, 6-bromo-4-chlorothieno[3,2-d]pyrimidineRelated Search:
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