(4-Chlorophenyl)-difluoroacetic acid

Product Name: (4-Chlorophenyl)-difluoroacetic acid
CAS No.: 130754-19-7
Chemical Name: (4-Chlorophenyl)-difluoroacetic acid
Synonyms: (4-Chlorophenyl)-difluoroacetic acid;Ethyl 4-Chloro-alpha,alpha-difluorophenylacetate;Benzeneacetic acid, 4-chloro-α,α-difluoro-, ethyl ester;Benzeneacetic acid, 4-chloro-α,α-difluoro-, ethyl ester
CBNumber: CB51856342
Molecular Formula: C10H9ClF2O2
Formula Weight: 234.63
MOL File: 130754-19-7.mol

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(4-Chlorophenyl)-difluoroacetic acid Property

Boiling point:: 267.1±35.0 °C(Predicted)
Density: 1.286±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
Appearance: Colorless to light yellow Liquid

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Safety

HS Code: 2916391000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: E903703
Product name: Ethyl2-(4-chlorophenyl)-2,2-difluoroacetate
Packaging: 1g
Price: $185
Updated: 2021/12/16

AK Scientific

Product number: 5712CZ
Product name: Ethyl2-(4-Chlorophenyl)-2,2-difluoroacetate
Packaging: 5g
Price: $640
Updated: 2021/12/16

Ambeed

Product number: A263653
Product name: Ethyl2-(4-Chlorophenyl)-2,2-difluoroacetate
Purity: 95%
Packaging: 100mg
Price: $44
Updated: 2021/12/16

Ambeed

Product number: A263653
Product name: Ethyl2-(4-Chlorophenyl)-2,2-difluoroacetate
Purity: 95%
Packaging: 250mg
Price: $65
Updated: 2021/12/16

Ambeed

Product number: A263653
Product name: Ethyl2-(4-Chlorophenyl)-2,2-difluoroacetate
Purity: 95%
Packaging: 1g
Price: $141
Updated: 2021/12/16

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(4-Chlorophenyl)-difluoroacetic acid Chemical Properties,Usage,Production

Synthesis

637-87-6

667-27-6

130754-19-7

To a stirred solution of p-chloroiodobenzene (15.0 g, 63 mmol) and ethyl difluorobromoacetate (12.8 g, 63 mmol) in DMSO (300 mL) was added copper powder (8.0 g). The mixture was heated to 80 °C and stirred for 20 hours. After the reaction was completed, the mixture was cooled to room temperature and poured into an aqueous solution (1.5 L) of K2HPO4-3H2O (11.0 g). After stirring for 30 min at room temperature, the mixture was filtered through a diatomaceous earth pad and the filter cake was washed with ether. The combined organic phases were washed sequentially with water and brine, dried with Na2SO4 and concentrated. Purification by silica gel column chromatography (eluent: hexane) afforded ethyl 2-(4-chlorophenyl)-2,2-difluoroacetate as a colorless oil (6.8 g, 46% yield).1H NMR (400 MHz, CDCl3) δ 7.55 (d, J = 8.4 Hz, 2H), 7.44 (d, J = 8.4 Hz, 2H), 4.30 (q, J = 7.1 Hz, 2H), 1.31 (t, J = 7.1 Hz, 3H).

References

[1] Patent: WO2016/44323, 2016, A1. Location in patent: Paragraph 0368
[2] Chemical Communications, 2016, vol. 52, # 8, p. 1598 - 1601
[3] European Journal of Organic Chemistry, 2016, vol. 2016, # 33, p. 5529 - 5538
[4] Patent: WO2006/113471, 2006, A2. Location in patent: Page/Page column 26; 48

(4-Chlorophenyl)-difluoroacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(4-Chlorophenyl)-difluoroacetic acid Suppliers

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130754-19-7, (4-Chlorophenyl)-difluoroacetic acidRelated Search:

Difluoroacetic acid

(4-Chlorophenyl)-difluoroacetic acid

Ethyl 4-Chloro-alpha,alpha-difluorophenylacetate

Benzeneacetic acid, 4-chloro-α,α-difluoro-, ethyl ester

130754-19-7