Difluoroacetic acid

Product Name: Difluoroacetic acid
CAS No.: 381-73-7
Chemical Name: Difluoroacetic acid
Synonyms: 2,2-DIFLUOROACETIC ACID;DIFLUOROACETATE;ifluoroaceticaci;difluoro-aceticaci;VITAS-BB TBB000649;DIFLUOROACETIC ACID;Difluoroaceticacid98%;Acetic acid, difluoro-;1,1-DIFLUOROACETIC ACID;Twotrifluoroacetic acid
CBNumber: CB2700577
Molecular Formula: C2H2F2O2
Formula Weight: 96.03
MOL File: 381-73-7.mol

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Difluoroacetic acid Property

Melting point:: -1 °C (lit.)
Boiling point:: 132-134 °C (lit.)
Density: 1.526 g/mL at 25 °C (lit.)
vapor pressure: 11.7hPa at 25℃
refractive index: n20/D 1.344(lit.)
Flash point:: 174 °F
storage temp.: 2-8°C
solubility: 540.54g/L in organic solvents at 20 ℃
form: Liquid
pka: pK1:1.33 (25°C)
color: Clear colorless to light brown
Specific Gravity: 1.527 (20℃)
Water Solubility: 1000g/L at 37℃
BRN: 1098588
InChIKey: PBWZKZYHONABLN-UHFFFAOYSA-N
LogP: 0.601 at 37℃
CAS DataBase Reference: 381-73-7(CAS DataBase Reference)
NIST Chemistry Reference: Difluoroacetic acid(381-73-7)
EPA Substance Registry System: Acetic acid, difluoro- (381-73-7)

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Safety

Hazard Codes: C
Risk Statements: 34-35
Safety Statements: 26-36/37/39-45
RIDADR: UN 3265 8/PG 2
WGK Germany: 3
RTECS: AG9900000
Hazard Note: Corrosive
TSCA: T
HazardClass: 8
PackingGroup: II
HS Code: 29159080

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H332Harmful if inhaled

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 142859
Product name: Difluoroacetic acid
Purity: 98%
Packaging: 5g
Price: $81.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: 00922
Product name: Difluoroacetic acid
Purity: for LC-MS LiChropur<SUP>™</SUP>, ≥97.5% (GC)
Packaging: 1 mL
Price: $49.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: 00922
Product name: Difluoroacetic acid
Purity: for LC-MS LiChropur<SUP>™</SUP>, ≥97.5% (GC)
Packaging: 1 mL
Price: $49.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: 142859
Product name: Difluoroacetic acid
Purity: 98%
Packaging: 25g
Price: $197
Updated: 2025/07/31

Sigma-Aldrich

Product number: 00922
Product name: Difluoroacetic acid
Purity: for LC-MS LiChropur?, ≥97.5% (GC)
Packaging: 10X1ML
Price: $304
Updated: 2025/07/31

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Difluoroacetic acid Chemical Properties,Usage,Production

Chemical Properties

clear colorless to light brown liquid

Uses

Used in the preparation of 2-difluoromethylbenzimidazoles, -oxazoles and -thiazoles from ortho-substituted anilines mediated by triphenylphoshine.

Definition

ChEBI: A monocarboxylic acid that is acetic acid in which two of the methyl hydrogens are substituted by fluorines.

Flammability and Explosibility

Non flammable

Synthesis

79-43-6

381-73-7

The following is the generic synthesis procedure employed in Examples 10 to 12: 2 g of dichloroacetic acid was added to an aqueous solution of potassium fluoride (KF) preheated to 120°C. The reaction system was kept continuously stirred at 120°C for 1 hour. Upon completion of the reaction, the system was cooled to room temperature and the aqueous solution was subsequently analyzed by nuclear magnetic resonance hydrogen spectroscopy (1H NMR) and nuclear magnetic resonance fluorine spectroscopy (19F NMR). The specific operating conditions and corresponding results are detailed in the following table (III).

Purification Methods

Purify the acid by distilling over P2O5. The acid chloride is a fuming liquid b 25o/atm, and the amide has b 108.6o/35mm, m 52o (from *C6H6), and the anilide has b 90o/1mm, 114o/5mm, m 58o [Henne & Pelley J Am Chem Soc 74 1426 1952, Coffman et al. J Org Chem 14 749 1949, NMR: Meyer et al. J Am Chem Soc 75 4567 1953, pK: Wegscheider Z Phys Chem 69 614 1909]. [Beilstein 2 IV 455.]

References

[1] Patent: US2013/131375, 2013, A1. Location in patent: Paragraph 0116; 0117; 0118; 0119

Difluoroacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Difluoroacetic acid Suppliers

Americas 1 Belgium 2 Brazil 1 China 281 Europe 4 France 1 Germany 5 India 17 Ireland 1 Japan 7 Jordan 1 Russia 3 Slovakia 1 South Korea 2 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 17 United States 36 Global 384

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View Lastest Price from Difluoroacetic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Difluoroacetic acid 381-73-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-22

Henan Aochuang Chemical Co.,Ltd.

Product: Difluoroacetic acid 381-73-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

Zibo Hangyu Biotechnology Development Co., Ltd

Product: Difluoroacetic acid 381-73-7
Price: US $90.00-900.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-11-08

381-73-7, Difluoroacetic acidRelated Search:

Ethyl 2-(Chlorosulfonyl)acetate 2-Bromo-2,2-difluoroacetic acid ethyl ester Glycine Folic acid Trifluoroacetic acid Trifluoroacetic anhydride DIFLUOROACETIC ACID ETHYL ESTER,ETHYL DIFLUOROACETIC ACID Fluroxypyr DIFLUOROACETIC ACID METHYL ESTER,α,2-Difluoroacetic acid methyl ester Ethyl trifluoroacetate Chlorodifluoroacetic acid ethyl ester Sodium chlorodifluoroacetate Diethyl 2,2-difluoromalonate Citric acid Ascoric Acid DIFLUOROACETIC ACID ANHYDRIDE TRIMETHYLSILYL TRIFLUOROACETATE THALLIUM(III) TRIFLUOROACETATE

2,2-DIFLUOROACETIC ACID

1,1-DIFLUOROACETIC ACID

VITAS-BB TBB000649

DIFLUOROACETIC ACID

Acetic acid, difluoro-

difluoro-aceticaci

DIFLUOROACETATE

Difluoroaceticacid98%

Difluoroacetic acid, 98% 10ML

Difluoroacetic acid, 98% 2.5ML

2,2-Difluoroethanoic acid

Twotrifluoroacetic acid

Aceticacid, 2,2-difluoro-

Difluoroacetic acid, 97%+

Difluoroacetic Acid &gt

ifluoroaceticaci

Difluoroaceticacid(DFA)

381-73-7

7381-73-7

F2CHCO2H

F2CHCOOH

CHF2COOH

C2H2F2O2

CARBOXYLIC ACID

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