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Difluoroacetic acid

Product Name
Difluoroacetic acid
CAS No.
381-73-7
Chemical Name
Difluoroacetic acid
Synonyms
2,2-DIFLUOROACETIC ACID;DIFLUOROACETATE;ifluoroaceticaci;difluoro-aceticaci;VITAS-BB TBB000649;DIFLUOROACETIC ACID;Difluoroaceticacid98%;Acetic acid, difluoro-;1,1-DIFLUOROACETIC ACID;Twotrifluoroacetic acid
CBNumber
CB2700577
Molecular Formula
C2H2F2O2
Formula Weight
96.03
MOL File
381-73-7.mol
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Difluoroacetic acid Property

Melting point:
-1 °C (lit.)
Boiling point:
132-134 °C (lit.)
Density 
1.526 g/mL at 25 °C (lit.)
vapor pressure 
11.7hPa at 25℃
refractive index 
n20/D 1.344(lit.)
Flash point:
174 °F
storage temp. 
2-8°C
solubility 
540.54g/L in organic solvents at 20 ℃
form 
Liquid
pka
pK1:1.33 (25°C)
color 
Clear colorless to light brown
Specific Gravity
1.527 (20℃)
Water Solubility 
1000g/L at 37℃
BRN 
1098588
InChIKey
PBWZKZYHONABLN-UHFFFAOYSA-N
LogP
0.601 at 37℃
CAS DataBase Reference
381-73-7(CAS DataBase Reference)
NIST Chemistry Reference
Difluoroacetic acid(381-73-7)
EPA Substance Registry System
Acetic acid, difluoro- (381-73-7)
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Safety

Hazard Codes 
C
Risk Statements 
34-35
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3265 8/PG 2
WGK Germany 
3
RTECS 
AG9900000
Hazard Note 
Corrosive
TSCA 
T
HazardClass 
8
PackingGroup 
II
HS Code 
29159080
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

H332Harmful if inhaled

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
142859
Product name
Difluoroacetic acid
Purity
98%
Packaging
5g
Price
$78.8
Updated
2024/03/01
Sigma-Aldrich
Product number
142859
Product name
Difluoroacetic acid
Purity
98%
Packaging
25g
Price
$191
Updated
2024/03/01
Sigma-Aldrich
Product number
00922
Product name
Difluoroacetic acid
Purity
for LC-MS LiChropur?, ≥97.5% (GC)
Packaging
10X1ML
Price
$252
Updated
2022/05/15
Sigma-Aldrich
Product number
00922
Product name
Difluoroacetic acid
Purity
for LC-MS LiChropur?, ≥97.5% (GC)
Packaging
50ML
Price
$802
Updated
2022/05/15
TCI Chemical
Product number
D1423
Product name
Difluoroacetic Acid
Purity
>97.0%(T)
Packaging
5g
Price
$50
Updated
2024/03/01
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Difluoroacetic acid Chemical Properties,Usage,Production

Chemical Properties

clear colorless to light brown liquid

Uses

Used in the preparation of 2-difluoromethylbenzimidazoles, -oxazoles and -thiazoles from ortho-substituted anilines mediated by triphenylphoshine.

Definition

ChEBI: A monocarboxylic acid that is acetic acid in which two of the methyl hydrogens are substituted by fluorines.

Flammability and Explosibility

Non flammable

Purification Methods

Purify the acid by distilling over P2O5. The acid chloride is a fuming liquid b 25o/atm, and the amide has b 108.6o/35mm, m 52o (from *C6H6), and the anilide has b 90o/1mm, 114o/5mm, m 58o [Henne & Pelley J Am Chem Soc 74 1426 1952, Coffman et al. J Org Chem 14 749 1949, NMR: Meyer et al. J Am Chem Soc 75 4567 1953, pK: Wegscheider Z Phys Chem 69 614 1909]. [Beilstein 2 IV 455.]

Difluoroacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Difluoroacetic acid manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Difluoroacetic acid 381-73-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-11-22
Zibo Hangyu Biotechnology Development Co., Ltd
Product
Difluoroacetic acid 381-73-7
Price
US $90.00-900.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-11-08
Hefei TNJ Chemical Industry Co.,Ltd.
Product
Difluoroacetic Acid 381-73-7
Price
US $0.00/L
Min. Order
200L
Purity
99%
Supply Ability
1000MT
Release date
2019-03-08

381-73-7, Difluoroacetic acidRelated Search:


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