(4-Chlorophenyl)-difluoroacetic acid
- Product Name
- (4-Chlorophenyl)-difluoroacetic acid
- CAS No.
- 130754-19-7
- Chemical Name
- (4-Chlorophenyl)-difluoroacetic acid
- Synonyms
- (4-Chlorophenyl)-difluoroacetic acid;Ethyl 4-Chloro-alpha,alpha-difluorophenylacetate;Benzeneacetic acid, 4-chloro-α,α-difluoro-, ethyl ester;Benzeneacetic acid, 4-chloro-α,α-difluoro-, ethyl ester
- CBNumber
- CB51856342
- Molecular Formula
- C10H9ClF2O2
- Formula Weight
- 234.63
- MOL File
- 130754-19-7.mol
(4-Chlorophenyl)-difluoroacetic acid Property
- Boiling point:
- 267.1±35.0 °C(Predicted)
- Density
- 1.286±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2916391000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E903703
- Product name
- Ethyl2-(4-chlorophenyl)-2,2-difluoroacetate
- Packaging
- 1g
- Price
- $185
- Updated
- 2021/12/16
- Product number
- 5712CZ
- Product name
- Ethyl2-(4-Chlorophenyl)-2,2-difluoroacetate
- Packaging
- 5g
- Price
- $640
- Updated
- 2021/12/16
- Product number
- A263653
- Product name
- Ethyl2-(4-Chlorophenyl)-2,2-difluoroacetate
- Purity
- 95%
- Packaging
- 100mg
- Price
- $44
- Updated
- 2021/12/16
- Product number
- A263653
- Product name
- Ethyl2-(4-Chlorophenyl)-2,2-difluoroacetate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- A263653
- Product name
- Ethyl2-(4-Chlorophenyl)-2,2-difluoroacetate
- Purity
- 95%
- Packaging
- 1g
- Price
- $141
- Updated
- 2021/12/16
(4-Chlorophenyl)-difluoroacetic acid Chemical Properties,Usage,Production
Synthesis
637-87-6
667-27-6
130754-19-7
To a stirred solution of p-chloroiodobenzene (15.0 g, 63 mmol) and ethyl difluorobromoacetate (12.8 g, 63 mmol) in DMSO (300 mL) was added copper powder (8.0 g). The mixture was heated to 80 °C and stirred for 20 hours. After the reaction was completed, the mixture was cooled to room temperature and poured into an aqueous solution (1.5 L) of K2HPO4-3H2O (11.0 g). After stirring for 30 min at room temperature, the mixture was filtered through a diatomaceous earth pad and the filter cake was washed with ether. The combined organic phases were washed sequentially with water and brine, dried with Na2SO4 and concentrated. Purification by silica gel column chromatography (eluent: hexane) afforded ethyl 2-(4-chlorophenyl)-2,2-difluoroacetate as a colorless oil (6.8 g, 46% yield).1H NMR (400 MHz, CDCl3) δ 7.55 (d, J = 8.4 Hz, 2H), 7.44 (d, J = 8.4 Hz, 2H), 4.30 (q, J = 7.1 Hz, 2H), 1.31 (t, J = 7.1 Hz, 3H).
References
[1] Patent: WO2016/44323, 2016, A1. Location in patent: Paragraph 0368
[2] Chemical Communications, 2016, vol. 52, # 8, p. 1598 - 1601
[3] European Journal of Organic Chemistry, 2016, vol. 2016, # 33, p. 5529 - 5538
[4] Patent: WO2006/113471, 2006, A2. Location in patent: Page/Page column 26; 48
(4-Chlorophenyl)-difluoroacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
(4-Chlorophenyl)-difluoroacetic acid Suppliers
- Tel
- --
- Fax
- --
- info@synthonix.com
- Country
- United States
- ProdList
- 6872
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@combi-blocks.com
- Country
- United States
- ProdList
- 6618
- Advantage
- 69
- Tel
- --
- Fax
- --
- sales@oakwoodchemical.com
- Country
- United States
- ProdList
- 6193
- Advantage
- 74