2-Pyridin-4-ylacetohydrazide
- Product Name
- 2-Pyridin-4-ylacetohydrazide
- CAS No.
- 69583-00-2
- Chemical Name
- 2-Pyridin-4-ylacetohydrazide
- Synonyms
- 2-Pyridin-4-ylacetohydrazide;4-Pyridineacetic acid hydrazide;2-pyridin-4-ylacetohydrazide(SALTDATA: FREE)
- CBNumber
- CB51873837
- Molecular Formula
- C7H9N3O
- Formula Weight
- 151.17
- MOL File
- 69583-00-2.mol
2-Pyridin-4-ylacetohydrazide Property
- Melting point:
- 85-86 °C(Solv: benzene (71-43-2))
- Boiling point:
- 416.8±28.0 °C(Predicted)
- Density
- 1.208±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 12.38±0.37(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P840485
- Product name
- 2-(Pyridin-4-yl)acetohydrazide
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- Y5522
- Product name
- 2-(Pyridin-4-yl)acetohydrazide
- Packaging
- 10g
- Price
- $705
- Updated
- 2021/12/16
- Product number
- CHM0136600
- Product name
- 2-PYRIDIN-4-YLACETOHYDRAZIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $721.57
- Updated
- 2021/12/16
- Product number
- CHM0136600
- Product name
- 2-PYRIDIN-4-YLACETOHYDRAZIDE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $983.88
- Updated
- 2021/12/16
- Product number
- CHM0136600
- Product name
- 2-PYRIDIN-4-YLACETOHYDRAZIDE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1168.42
- Updated
- 2021/12/16
2-Pyridin-4-ylacetohydrazide Chemical Properties,Usage,Production
Synthesis
54401-85-3
69583-00-2
General procedure for the synthesis of 2-(pyridin-4-yl)acetohydrazide from ethyl 4-pyridyl acetate: a mixture of hydrazine hydrate (0.27 mL, 9.08 mmol), ethyl pyridin-4-yl acetate (0.93 mL, 6.05 mmol), and ethanol (10 mL) was heated and reacted for 10 hours at 80 °C. Subsequently, hydrazine hydrate (0.6 mL) was added to the reaction system and the reaction continued to be heated at 80 °C for 14 hours. After completion of the reaction, the reaction solution was cooled to room temperature and concentrated under vacuum. The final 2-(pyridin-4-yl)acetylhydrazine (0.86 g, 95% yield) was obtained as a white solid. The structure of the product was confirmed by 1H NMR (DMSO-d6) and mass spectra (MS): 1H NMR (DMSO-d6) δ 9.29 (s, 1H), 8.47 (d, J = 5.6 Hz, 2H), 7.27 (d, J = 5.2 Hz, 2H), 4.28 (s, 2H), 3.39 (s, 2H); MS m/z 152 (M + 1).
References
[1] European Journal of Medicinal Chemistry, 2010, vol. 45, # 11, p. 4788 - 4796
[2] Journal of Labelled Compounds and Radiopharmaceuticals, 2016, vol. 59, # 14, p. 665 - 672
[3] Patent: WO2004/101512, 2004, A2. Location in patent: Page 87
[4] ChemMedChem, 2015, vol. 10, # 11, p. 1875 - 1883
[5] Journal of the American Chemical Society, 1953, vol. 75, p. 1933,1934
2-Pyridin-4-ylacetohydrazide Preparation Products And Raw materials
Raw materials
Preparation Products
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