CYTOCHALASIN E Property

Melting point:

206 °C

Boiling point:

587.59°C (rough estimate)

Density 

1.2415 (rough estimate)

refractive index 

1.6290 (estimate)

storage temp. 

-20°C

solubility 

DMF: 11 mg/ml; DMF:PBS (pH7.2) (1:30): 0.03 mg/ml; DMSO: 10 mg/ml; Ethanol: 2 mg/ml

form 

White solid.

pka

11.22±0.70(Predicted)

color 

White to off-white

BRN 

1096975

LogP

1.920 (est)

Safety

Hazard Codes 

T+,T

Risk Statements 

26/27/28-63

Safety Statements 

28-36/37-45

RIDADR 

UN 1544 6.1/PG 2

WGK Germany 

3

RTECS 

HA5360000

F 

10

HazardClass 

6.1(a)

PackingGroup 

I

HS Code 

29349990

Hazardous Substances Data

36011-19-5(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H310Fatal in contact with skin

H330Fatal if inhaled

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P350IF ON SKIN: Gently wash with plenty of soap and water.

CYTOCHALASIN E Chemical Properties,Usage,Production

Description

The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin E is an epoxide-containing analog of cytochalasin B which potently and selectively inhibits the growth of endothelial cells (IC₅₀ < 1 nM), impairing angiogenesis and tumor growth. This cytochalasin does not inhibit glucose transport or HIV-1 protease activity.

Chemical Properties

white powder

Uses

Cytochalasin E is one of a family of potent mycotoxins produced by a range of fungi. All members of the class exhibit profound effects on cytoskeletal proteins, resulting in pronounced morphogenic changes in animals and plants. Despite the common mode of action, there is evidence that individual members display diverse selectivity. Specifically, cytochalasin E acts as an angiogenesis inhibitor and, unlike other cytochalasins, does not inhibit glucose transport.

Uses

Cytochalasin E is a fungal metabolite which has been shown to exhibit antimicrobial and antibacterial effects. Cytochalasin E is a microfilament inhibitor enhancing the low-affinity Fc epsilon receptor (CD23) expression.

Uses

Cytochalasin E has been used as:

• a toxin to study its effects on avocado plants
• a component of the incubating medium in feline junctional adhesion molecule 1 (fJAM-1) expression assay
• an inhibitor of actin polymerization to study its effects on mitochondria uptake by mice endothelial cells

Definition

ChEBI: A natural product found in Arthrinium sacchari.

Biochem/physiol Actions

Cytochalasin E is an epoxide that exhibits anti-proliferative activity in endothelial cells in vitro. It also participates in inhibiting tumor growth and angiogenesis in vivo. Cytochalasin E also possesses antimicrobial and antiviral properties.