Hexaflumuron

ChemicalBook > CAS DataBase List > Hexaflumuron

Description mechanism of action uses toxicity reference

Product Name: Hexaflumuron
CAS No.: 86479-06-3
Chemical Name: Hexaflumuron
Synonyms: CONSOL;xrd473;Trueno;DE-473;CONSULT;OMS-3031;ai3-29832;Consult(TM;CONSULT(R);Hexafluron
CBNumber: CB5193224
Molecular Formula: C16H8Cl2F6N2O3
Formula Weight: 461.14
MOL File: 86479-06-3.mol

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Hexaflumuron Property

Melting point:: 197-199°
Density: 1.4069 (estimate)
vapor pressure: 5.9 x l0^-5 Pa (25 °C)
storage temp.: Sealed in dry,2-8°C
solubility: DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml
Water Solubility: 2.7 x l0^-22 mg l^-1 (18 °C)
pka: 8.54±0.46(Predicted)
BRN: 8168725
Stability:: Stable. Incompatible with strong oxidizing agents.
InChIKey: RGNPBRKPHBKNKX-UHFFFAOYSA-N
CAS DataBase Reference: 86479-06-3(CAS DataBase Reference)
EPA Substance Registry System: Hexaflumuron (86479-06-3)

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Safety

Hazard Codes: N
Risk Statements: 50/53
Safety Statements: 60-61
RIDADR: UN 3077
WGK Germany: 2
RTECS: CV3800000
HazardClass: 9
PackingGroup: III
Hazardous Substances Data: 86479-06-3(Hazardous Substances Data)
Toxicity: LD50 oral in rat: > 5gm/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 37902
Product name: Hexaflumuron
Purity: PESTANAL?, analytical standard
Packaging: 100mg
Price: $132
Updated: 2024/03/01

Sigma-Aldrich

Product number: 37902
Product name: Hexaflumuron
Purity: PESTANAL
Packaging: 100mg-r
Price: $103
Updated: 2021/12/16

Cayman Chemical

Product number: 18598
Product name: Hexaflumuron
Purity: ≥95%
Packaging: 50mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 18598
Product name: Hexaflumuron
Purity: ≥95%
Packaging: 100mg
Price: $98
Updated: 2024/03/01

Cayman Chemical

Product number: 18598
Product name: Hexaflumuron
Packaging: 25mg
Price: $32
Updated: 2024/03/01

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Hexaflumuron Chemical Properties,Usage,Production

Description

Hexaflumuron is a termite pesticide, the first “reduced-risk pesticide” registered by the US EPA. Unlike traditional methods, it is regurgitated at the nest – allowing it to be applied in environmentally-friendly baiting stations, rather than liquid chemical barriers. It is an Insect Growth Regulator (IGR), acting on the synthesis of chitin, the main component of the exoskeleton. Its clearance and metabolism is slow, allowing for a high degree of bioconcentration. It can be used against subterranean termite colonies for wood structures including buildings, fences, trees, decking, and more, to control Reticulitermes, Coptotermes, and Heterotemes.

mechanism of action

Hexaflumuron is an insect growth regulator (IGR) that works by inhibiting the insect’s growth. It interferes with chitin synthesis, which termites need to form a new exoskeleton.
Hexaflumuron is part of a pest monitoring system and is used selectively only in baiting stations where termite activity is present and only when the activity continues. Termites are social insects that share food and feeding sites. Foraging termites recruit nestmates to feeding sites by leaving a pheromone trail to the site, allowing the entire nest to feed on the bait containing hexaflumuron.
Pest control operators use hexaflumuron as part of aboveground and underground baiting systems. They place it in a tamper-resistant bait station where foraging termites consume it.

uses

Hexaflumuron is used to control subterranean termite colonies. It is used in above-ground and inground bait stations as part of termite monitoring and control programs. Target sites include buildings, fences, utility poles, decking, landscape plantings, trees, and other wood structures that can be damaged by termite foraging and feeding. Hexaflumuron products are used only by licensed pest management professionals.
Hexaflumuron is registered by the U.S. Environmental Protection Agency (EPA) for use as termite bait. End-use termite bait formulations containing hexaflumuron are registered and sold in more than 25 countries including Australia, Brazil, China, France, Japan, Spain, and the United States. Formulations are packaged into bait stations for in-ground installation around structures and in stations for above-ground installation.

toxicity

Animals
Hexaflumuron has a low toxicity when fed to rats in laboratory studies. See boxes on LD50,Laboratory Testing box and Toxicity Categories.
Laboratory tests indicate hexaflumuron is nonirritating to the skin and eyes of rabbits.
Humans
Scientists do not consider hexaflumuron a skin sensitizer.

reference

http://msdssearch.dow.com/PublishedLiteratureDOWCOM/dh_091b/0901b8038091b652.pdf?filepath=productsafety/pdfs/noreg/233-00932.pdf&fromPage=GetDoc
http://npic.orst.edu/factsheets/hexgen.pdf
http://www.doityourselftermitecontrol.com/chemical-termite-treatments.html
https://www.caymanchem.com/product/18598
http://dissemination.echa.europa.eu/Biocides/ActiveSubstances/1314-18/1314-18_Assessment_Report.pdf
https://npic.orst.edu/factsheets/archive/hextech.pdf
https://www.epestcontrol.com/images/Products/labels/hexaflumeroninfosheet.pdf

Description

Hexaflumuron is a benzoylphenyl urea-type insecticide and is the common name for N-(((3,5- dichloro-4-(1,1,2,2-tetrafluoro-ethoxy)phenyl)amino)carbonyl)-2,6-difluorobenzamide. It the active ingredient in several termite control products registered to Dow AgroSciences LLC, a wholly owned subsidiary of The Dow Chemical Company. Hexaflumuron was the first active ingredient to be registered with the U.S. Environmental Protection Agency (EPA) as a reduced-risk pesticide. A reduced-risk pesticide is one that the EPA believes has low impact on human health, low toxicity to non-target organisms, and low potential for groundwater contamination. Hexaflumuron’s mode of action is to inhibit chitin synthesis. Termites produce chitin to form or maintain an exoskeleton.
Hexaflumuron is an odorless white solid that is formulated into low-concentration solid briquettes that are contained within tamper-resistant bait stations. Formulated hexaflumuron briquettes contain about 0.5% of the active ingredient, with the balance comprised almost entirely of cellulose.
Hexaflumuron formulations have been marketed under the trade names RECRUIT® AG termite bait, SHATTER*termite bait, SENTRI*TECH, RECRUTE® Pro, Hex-Pro(TM) Termite Baiting System, Sentricon(TM) IG Termite Bait, Sentricon(TM) AG Termite Bait, Sentricon® Termite Colony Elimination System.

Chemical Properties

White solid or powder. The commercial product may be an emulsifiable concentrate.

Uses

Hexaflumuron is an benzoylphenylurea based chitin synthesis inhibitor used against Ephestia figulilella.

Uses

Hexaflumuron is used for the control of larvae of Lepidoptera, Coleoptera, Homoptera and Diptera on top fruit, cotton and vegetables. It is also used in forestry.

Definition

ChEBI: An N-acylurea that is urea in which a hydrogen attached to one of the nitrogens is replaced by a 2,6-difluorobenzoyl group, while a hycrogen attached to the other nitorgen is replaced by a 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl group.

Potential Exposure

Hexaflumuron is a benzoyl urea insecti cide, termiticide and insect growth regulator (IGR) that inhi bits an insect’s growth through chitin synthesis, which termites need to form an exoskeleton. It is used to impregnate termite bait. Worldwide, there are more than 20 suppliers/ manufacturers; most are in the United States Not currently registered for agricultural use in some EU countries.

Metabolic pathway

Although there is limited dormation on the metabolism of hexaflumuron in the open literature, there is a useful summary provided by Dow Agrosciences (Anon). Metabolic pathways are shown in Scheme 1.

Shipping

UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous haz ardous material, Technical Name Required.

Degradation

Hexaflumuron is stable to hydrolysis at pH 5.0 (25°C) over 33 days and hydrolysis at pH 7.0 is slow (6% in 33 days). However, hydrolysis at pH 9.0 was more rapid (DT₅₀ 21-23 days). Alkaline hydrolysis followed two separate routes, namely the formation of 2,6-difluorobenzoic acid (2) and 3,5-dichloro-4-( 1,1,2,2-tetrafluoroethoxy)phenylurea (3) and a slower reaction to form 2,6-difluorobenzamide (4) and 3,5-dichloro-4-( 1,1,2,2- tetrafluoroethoxy)anilhe (5).
When [¹⁴C-aniline] and [¹⁴C-benzoyl]hexaflumuron were irradiated in sterile aqueous buffer at pH 5, the DT₅₀ was approximately 6.3 days. The major photolysis product from the benzoyl label was 4 (96% of the applied radioactivity) and from the aniline label was 3,5-dichloro-4- hydroxyaniline (6). The latter comprised 35% of the applied radioactivity and a further 60% was released as ¹⁴CO₂ from the aniline label indicating extensive ring-opening.

Incompatibilities

Decomposes in temperatures above 275 C. Irritating or toxic fumes or gases in a fire

Waste Disposal

Do not discharge into drains or sewers. Dispose of waste material as hazardous waste using a licensed disposal contractor to an approved land fill. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Incineration with effluent gas scrubbing is recommended. Containers must be disposed of properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

Hexaflumuron Preparation Products And Raw materials

Raw materials

Flufenoxuron 4-(1,1,2,2-TETRAFLUOROETHOXY)ANILINE Sulfolane Potassium fluoride Phenyl isocyanate 2,6-Difluorobenzamide 2,6-Difluorobenzoyl isocyanate Chlorfluazuron PHOSGENE Cyanhydric acid Oxalyl chloride

Preparation Products

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View Lastest Price from Hexaflumuron manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: Hexaflumuron 86479-06-3
Price: US $200.00/Kg/Drum
Min. Order: 1KG
Purity: 95%;98%
Supply Ability: 20tons/month
Release date: 2020-09-01

Hebei Guanlang Biotechnology Co., Ltd.

Product: Hexaflumuron 86479-06-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2023-03-30

Hebei Mojin Biotechnology Co., Ltd

Product: hexaflumuron 86479-06-3
Price: US $0.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20ton
Release date: 2021-07-09

86479-06-3, HexaflumuronRelated Search:

Pyrethrins Dimefluthrin Glycine Phenylhydrazine ALTRENOGEST PHENYL VALERATE PYRAZOPHOS 4-(1,1,2,2-TETRAFLUOROETHOXY)ANILINE 3,5-Dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline 4-Amino-2,6-dichlorophenol Diflubenzuron W.P. Diflubenzuron METOXURON-MONOMETHYL 3-CHLORO-4-DIFLUOROMETHOXY-PHENYLAMINE 1-(3,5-dichlorophenyl)-3-methylurea 3-CHLORO-4-ETHOXYANILINE (2,6-Difluoro-benzyl)-urea Hexaflumuron

1-(3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl)-3-(2,6-difluorobenzoyl)

6-difluoro-)-

ai3-29832

benzamide,n-(((3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl)amino)carbonyl

Consult(TM

hexafluoron

xrd473

CONSOL

CONSULT

CONSULT(R)

HEXAFLUMURON

N-[3,5-DICHLORO-4-(1,1,2,2-TETRAFLUOROETHOXY)PHENYLCARBAMOYL]-2,6-DIFLUOROBENZAMIDE

hexaflumuron (bsi,iso)

1-[3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy) phenyl]-3-(2,6-difuorobenzoyl) urea

Trueno

DE-473

Hexafluron

N-(((3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl)amino)carbonyl)-2,6-difluorobenzamide

Hexaflumuron E.C.

OMS-3031

BenzaMide,N-[[[3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl]aMino]carbonyl]-2,6-difluoro-

Hexaflumuron 0

Hexaflumuron 250mg [86479-06-3]

Hexafluron Consult DE-473

Hexaflumuron Solution, 1000ppm

Hexaflumuron @100 μg/mL in Methanol

Hexaflumuron@1000 μg/mL in Acetonitrile

HexaflumuronSolution,100mg/L,1ml

Hexaflumuron Standard

Hexaflumuron Solution in Methanol, 100μg/mL

α-D-Glucopyranose 1-phosphate

Fluoride bell urea

Hexaflumuron Solution in Metha

Hexaflumuron Solution in Acetonitrile

Hexaflumuron Solution in Methanol

86479-06-3

367-38-5

C16H8ClF6N2O3

C16H8Cl2F6N2O3

INSECTICIDE