2,6-Difluorobenzamide
- Product Name
- 2,6-Difluorobenzamide
- CAS No.
- 18063-03-1
- Chemical Name
- 2,6-Difluorobenzamide
- Synonyms
- 2,6-difluorobenzoic acid amide;uorobenzamide;2,6-Difluorbenzamid;2,6-DIFLUOROBENZAMIDE;2,6-difluoro-benzamid;2，6-difluorobenzaminde;2,6-Difluorobenzoamide;2,6-Difluorobenzoylamide;2,6-Difluorobenzamide97%;2,6-Difluorobenzamide>
- CBNumber
- CB5376515
- Molecular Formula
- C7H5F2NO
- Formula Weight
- 157.12
- MOL File
- 18063-03-1.mol
2,6-Difluorobenzamide Property
- Melting point:
- 145-148 °C (lit.)
- Boiling point:
- 51-52C/15Tor
- Density
- 1,199g/cm
- refractive index
- 1,508
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- ethanol: soluble5%, clear to turbid, colorless to light yellow
- form
- Solid
- pka
- 14.54±0.50(Predicted)
- color
- Off-White
- BRN
- 2047480
- InChIKey
- AVRQBXVUUXHRMY-UHFFFAOYSA-N
- LogP
- 0.011-0.25 at 25℃
- CAS DataBase Reference
- 18063-03-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzamide, 2,6-difluoro-(18063-03-1)
- EPA Substance Registry System
- Benzamide, 2,6-difluoro- (18063-03-1)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20
- Safety Statements
- 26-37/39-36/37
- WGK Germany
- 1
- RTECS
- CV4355050
- HazardClass
- IRRITANT
- HS Code
- 29242990
- Toxicity
- rat,LC50,inhalation,> 2100mg/m3/4H (2100mg/m3),National Technical Information Service. Vol. OTS0543293,
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 282278
- Product name
- 2,6-Difluorobenzamide
- Purity
- 97%
- Packaging
- 10g
- Price
- $19.45
- Updated
- 2025/07/31
- Product number
- 282278
- Product name
- 2,6-Difluorobenzamide
- Purity
- 97%
- Packaging
- 50g
- Price
- $106
- Updated
- 2025/07/31
- Product number
- D1907
- Product name
- 2,6-Difluorobenzamide
- Purity
- >97.0%(N)
- Packaging
- 25g
- Price
- $30
- Updated
- 2025/07/31
- Product number
- D451843
- Product name
- 2,6-Difluorobenzamide
- Packaging
- 10g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- D451843
- Product name
- 2,6-Difluorobenzamide
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
2,6-Difluorobenzamide Chemical Properties,Usage,Production
Description
2,6-Difluorobenzamide is a major metabolite of pesticide diflubenzuron and has been quantitated by HPLC/diode-array method.
Description
2,6-Difluorobenzamide is a white powdery crystal, insoluble in water. It can be obtained by hydrolysis of 2,6-difluorobenzonitrile. 2,6-Difluorobenzamide is an important intermediate in the synthesis process of benzoylurea insecticides, which is used to synthesize the next intermediate 2,6-difluorobenzoyl isocyanate, and finally obtain flubolurea, pyruron, fluridin, lice mite urea and other pesticide varieties. It can also be directly used to synthesize pyruron and flubolea. 2,6-Difluorobenzamide can inhibit the bacterial cell division protein FtsZ[1].
Chemical Properties
white to yellowish powder
Uses
2,6-Difluorobenzamide (CAS# 18063-03-1) is a useful building block used in the synthesis of (E)-3-methyleneisoindolin-1-ones via oxidative annulation acrylates. It is also used in the synthesis of pesticide intermediates, which can be used to produce various insecticides such as fluazuron, chlorpyrifos, and pyrethroids.
Preparation
2,6-Difluorobenzamide is obtained by hydrolysis of 2,6-difluorobenzonitrile.
Synthesis
1897-52-5
18063-03-1
General procedure for the synthesis of 2,6-difluorobenzamide from 2,6-difluorobenzonitrile: (1) 100 g (0.72 mol) of 2,6-difluorobenzonitrile was added slowly and dropwise to a mixed solution of 240 g of concentrated sulfuric acid and 24 ml of water at room temperature. The reaction mixture was stirred at 80°C to 85°C for 12 hours. After completion of the reaction, the mixture was slowly poured into 1.2 kg of ice water and stirred continuously for 30 minutes, followed by filtration. The resulting crystals were washed to neutrality with distilled water and finally dried under vacuum at 85°C. The yield was 91.0 g (80.6% yield) with a melting point of 140°C to 141.5°C.
Toxics Screening Level
The Initial Threshold Screening Level (ITSL) for 2,6-Difluorobenzamide is 11 μg/m3 based on an annual averaging time.
References
[1] Straniero V, et al. 2,6-Difluorobenzamide inhibitors of the bacterial cell division protein FtsZ: design, synthesis and Structure Activity Relationship study. ChemMedChem, 2017; 12: 1303-1318.
2,6-Difluorobenzamide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-Difluorobenzamide manufacturers
- Product
- 2,6-Difluorobenzamide 18063-03-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-24
- Product
- 2,6-Difluorobenzamide 18063-03-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-01-29
- Product
- 2,6-Difluorobenzamide 18063-03-1
- Price
- US $1.00/KG
- Min. Order
- 200KG
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2018-08-08