Chemical properties Uses Production Method Hazards & Safety Information
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Teflubenzuron

Chemical properties Uses Production Method Hazards & Safety Information
Product Name
Teflubenzuron
CAS No.
83121-18-0
Chemical Name
Teflubenzuron
Synonyms
dart;MK139;HOE522;NOMOLT;NEMOLT;cme134;diaract;cme13406;TEFLURON;Terfluron
CBNumber
CB9155082
Molecular Formula
C14H6Cl2F4N2O2
Formula Weight
381.11
MOL File
83121-18-0.mol
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Teflubenzuron Property

Melting point:
221-224°
Density 
1.646±0.06 g/cm3(Predicted)
vapor pressure 
8 x 10 -7 mPa (20 °C)
storage temp. 
0-6°C
solubility 
DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
Water Solubility 
0.019 mg l-1 (23 °C)
pka
8.16±0.46(Predicted)
color 
White to Off-White
Merck 
13,9190
BRN 
8229925
LogP
4.98 at 20℃ and pH4.7
CAS DataBase Reference
83121-18-0(CAS DataBase Reference)
EPA Substance Registry System
Teflubenzuron (83121-18-0)
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Safety

RIDADR 
3077
WGK Germany 
2
RTECS 
CV3459590
HazardClass 
9
PackingGroup 
III
Toxicity
LD50 orally in rats: >5000 mg/kg (Becher)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P314Get medical advice/attention if you feel unwell.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
45756
Product name
Teflubenzuron
Purity
PESTANAL?, analytical standard
Packaging
250mg
Price
$73
Updated
2024/03/01
AK Scientific
Product number
P035
Product name
Teflubenzuron
Packaging
250mg
Price
$174
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0352707
Product name
TELFUBENZURON
Purity
95.00%
Packaging
5MG
Price
$495.02
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
42291
Product name
Teflubenzuron
Packaging
25g
Price
$1475
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PST0000194
Product name
TEFLUBENZURON
Purity
95.00%
Packaging
25G
Price
$2061.68
Updated
2021/12/16
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Teflubenzuron Chemical Properties,Usage,Production

Chemical properties

Pure Teflubenzuron is white crystal. m.p.223~225℃ (The original compound 222.5℃),saturated vapor pressure0.8×10-9Pa(20℃), relative density 1.68(20℃).  Its solubility at 20~23℃ are 66g/L in dimethyl sulfoxide, 20g/L in cyclohexanone, 10g/L in acetone, 1.4g/L in ethanol,  850mg/L in methylbenzene, 50mg/L in hexane,  0.02mg/L in water. Stable at room temperature. Its hydrolysis half-life period are 5d(pH=7)and 4h (pH=9) at 50℃ and 2~6 weeks in soil.

Uses

Teflubenzuron’s a fluorobenzoylurea insect growth regulator and a chitinase inhibitor. It achieves the insecticidal purpose through the inhibition of normal molting and development of larvae. It has a particularly high activity on lepidoptera pests, also achieves a good effect when it comes to the larvae of whitefly families, diptera, hymenoptera, coleoptera pests, but it’s invalid for many parasitic insects, predatory insects and spiders. It is mainly used on vegetables, fruit trees, cotton and teabush. E.g. 2000~4000 times diluent of EC can be applied by spraying to larvae of cabbage caterpillar and plutella xylostella in the egg incubation period to 1 to 2 instar.1500~3000 times diluent of EC can be applied by spraying to larvae of plutella xylostella, asparagus caterpillar, prodenia litura in the egg incubation period to 1 to 2 instar, which are resistant to organic phosphorus and pyrethroids. 1500~2000 times diluent of EC can be applied by spraying to cotton bollworm and pink worm in the egg incubation period of the second and third generations, and the elimination rate is about 85% after 10 days.

Production Method

Method 1
The addition reaction of 2,6-Difluorobenzamide and 2,4-difluoro-3,5-dichlorophenyl isocyanate
Method 2
preparation of 2,4-Difluoro-3,5-dichlorophenylamine
2,3,4,5-tetrachloronitrobenzene and Potassium fluoride react in DMF solvent at 140℃ for 15h to obtain 2,4-Difluoro-3,5-dichloronitrobenzene,which is then reduced to 2,4-Difluoro-3,5-dichlorophenylamine
Preparation of Teflubenzuron
 As for the preparation of 2,6-difluorobenzoyl isocyanate, see details in the preparation of  Teflubenzuron.
 2,6-difluorobenzoyl isocyanate and 2,4-Difluoro-3,5-dichlorophenylamine react at room temperature for 15h to obtain Teflubenzuron
 As for the nitrification, chlorination, reduction, fluorization and condensation of 1,2,4-Trichlorobenzene to  prepare Teflubenzuron, see details in bibliography.

Hazards & Safety Information

Category: Pesticide
Toxicity Grade: low toxicity
Acute Toxicity: LD50: 5000 mg/ kg(Rats oral)
Flammability: Flammable with toxic gases of nitrogen oxides, fluorides and chlorides
Storage: in dry ventilated storeroom at low temperature, away from food materials
Extinguishant: dry powder extinguisher, foam extinguisher, sand.

Uses

Teflubenzuron is used for the control of Lepidoptera, Coleoptera, Diptera, Aleyrodidae, Hymenoptera, Psyllidae and Hemiptera larvae on vines, pome fruit, citrus, vegetables, soyabeans, tobacco and cotton. It also controls fly and mosquito larvae and immature stages of locusts.

Uses

Teflubenzuron is an benzoylphenylurea chitin synthesis inhibitor used to control a wide range of insect pests and mites in fruit, vegetable, cereal and seed crops.

Uses

uSE: Insecticide.

Definition

ChEBI: Teflubenzuron is a N-acylurea that is N-carbamoyl-2,6-difluorobenzamide substituted by a 3,5-dichloro-2,4-difluorophenyl group at the terminal nitrogen atom. It has a role as a xenobiotic, an environmental contaminant and an insecticide. It is a dichlorobenzene, a N-acylurea and a difluorobenzene. It is functionally related to a N-benzoylurea.

Metabolic pathway

There is limited published information on the metabolism of teflubenzuron but an IPCS review is in preparation. Metabolic processes reported are cleavage of the urea bond and hydroxylation of both phenyl rings, including replacement of a fluorine in the 3,5-dichloro-2,4-difluorophenyl ring (see Scheme 1).

Degradation

Teflubenzuron is more readily hydrolysed at alkaline pH than in acid media. The DT50 at 50 °C was 5 days at pH 7 and 4 hours at pH 9 (PM).

Toxicity evaluation

Acute oral LD50 for rats: >5,000 mg/kg

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Teflubenzuron Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
Advantage
57
Wuhan Sinocon New chemical Materials Co.,ltd.
Tel
027-83229541 13971313286
Fax
027-83096702
Email
whsinocon@aliyun.com
Country
China
ProdList
127
Advantage
62
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14059
Advantage
65
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9725
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
24835
Advantage
65
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3750
Advantage
55
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9986
Advantage
55
TianJin Alta Scientific Co., Ltd.
Tel
022-65378550-8551
Fax
+86-022-2532-9655
Email
contact@altascientific.com
Country
China
ProdList
2773
Advantage
58
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View Lastest Price from Teflubenzuron manufacturers

Henan Fengda Chemical Co., Ltd
Product
teflubenzuron 83121-18-0
Price
US $9.00-0.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-23
Longyan Tianhua Biological Technology Co., Ltd
Product
Teflubenzuron 83121-18-0
Price
US $60.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2020-10-28
Career Henan Chemical Co
Product
Teflubenzuron 83121-18-0
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
Customized
Release date
2018-12-14

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