6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE

Product Name: 6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE
CAS No.: 502656-68-0
Chemical Name: 6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE
Synonyms: CAY10462;CAY10462 2HCl;CAY 10462 dihydrochloride;6-(4-imidazol-1-ylphenoxy)-N,N-dimethylhexan-1-amine:dihydrochloride;6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE
CBNumber: CB5194610
Molecular Formula: C17H27Cl2N3O
Formula Weight: 360.32
MOL File: Mol file

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6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE Property

solubility: DMSO: 15 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 10 mg/ml
form: A crystalline solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10006400
Product name: CAY10462
Purity: ≥98%
Packaging: 1mg
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 10006400
Product name: CAY10462
Purity: ≥98%
Packaging: 5mg
Price: $107
Updated: 2024/03/01

Cayman Chemical

Product number: 10006400
Product name: CAY10462
Purity: ≥98%
Packaging: 10mg
Price: $186
Updated: 2024/03/01

Cayman Chemical

Product number: 10006400
Product name: CAY10462
Purity: ≥98%
Packaging: 50mg
Price: $807
Updated: 2024/03/01

AK Scientific

Product number: 1480AH
Product name: 6-[4-(1H-Imidazol-1-yl)phenoxy]-n,n-dimethyl-1-hexanamine,dihydrochloride
Packaging: 50mg
Price: $997
Updated: 2021/12/16

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6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE Chemical Properties,Usage,Production

Description

20-HETE is an important metabolite of arachidonic acid in the vasculature, especially in the kidney, where it is synthesized by cytochrome P450 (CYP450) enzymes of the 4A family.^1,2 Alkylaryl imidazoles have been shown to inhibit certain CYP450 enzymes, including the CYP4A enzymes associated with 20-HETE synthesis.³ CAY10462 is the hydrochloride salt of CAY10434 and selective inhibitor of the 20-HETE synthase CYP4A11 exhibiting an IC₅₀ of 8.8 nM when tested in human renal microsomes.⁴ CAY10434 is nearly 200 times less potent as an inhibitor of 1A, 1C, and 3A CYP450 enzymes.

References

1. Harder, D.R., Lange, A.R., Gebremedhin, D., et al. Cytochrome P450 metabolites of arachidonic acid as intracellular signaling molecules in vascular tissue J. Vasc. Res. 34,237-243(1997).
2. Imig, J.D., Zou, A.P., Stec, D.E., et al. Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles Am. J. Physiol. 270,R217-R227(1996).
3. Nakamura, T., Kakinuma, H., Umemiya, H., et al. Imidazole derivatives as new potent and selective 20-HETE synthase inhibitor Bioorg. Med. Chem. Lett. 14,333-336(2004).

6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE Suppliers

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502656-68-0, 6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDERelated Search:

CAY10505 Benzamide, 4-(dimethylamino)-N-[3-[[2-[(4-oxo-4H-1-benzopyran-7-yl)oxy]acetyl]amino]phenyl]-

6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE

CAY10462

6-(4-imidazol-1-ylphenoxy)-N,N-dimethylhexan-1-amine:dihydrochloride

CAY10462 2HCl

CAY 10462 dihydrochloride

502656-68-0