ChemicalBook > CAS DataBase List > 6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE

6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE

Product Name
6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE
CAS No.
502656-68-0
Chemical Name
6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE
Synonyms
CAY10462;CAY10462 2HCl;CAY 10462 dihydrochloride;6-(4-imidazol-1-ylphenoxy)-N,N-dimethylhexan-1-amine:dihydrochloride;6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE
CBNumber
CB5194610
Molecular Formula
C17H27Cl2N3O
Formula Weight
360.32
MOL File
Mol file
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6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE Property

solubility 
DMSO: 15 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 10 mg/ml
form 
A crystalline solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10006400
Product name
CAY10462
Purity
≥98%
Packaging
1mg
Price
$25
Updated
2024/03/01
Cayman Chemical
Product number
10006400
Product name
CAY10462
Purity
≥98%
Packaging
5mg
Price
$107
Updated
2024/03/01
Cayman Chemical
Product number
10006400
Product name
CAY10462
Purity
≥98%
Packaging
10mg
Price
$186
Updated
2024/03/01
Cayman Chemical
Product number
10006400
Product name
CAY10462
Purity
≥98%
Packaging
50mg
Price
$807
Updated
2024/03/01
AK Scientific
Product number
1480AH
Product name
6-[4-(1H-Imidazol-1-yl)phenoxy]-n,n-dimethyl-1-hexanamine,dihydrochloride
Packaging
50mg
Price
$997
Updated
2021/12/16
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6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE Chemical Properties,Usage,Production

Description

20-HETE is an important metabolite of arachidonic acid in the vasculature, especially in the kidney, where it is synthesized by cytochrome P450 (CYP450) enzymes of the 4A family.1,2 Alkylaryl imidazoles have been shown to inhibit certain CYP450 enzymes, including the CYP4A enzymes associated with 20-HETE synthesis.3 CAY10462 is the hydrochloride salt of CAY10434 and selective inhibitor of the 20-HETE synthase CYP4A11 exhibiting an IC50 of 8.8 nM when tested in human renal microsomes.4 CAY10434 is nearly 200 times less potent as an inhibitor of 1A, 1C, and 3A CYP450 enzymes.

References

1. Harder, D.R., Lange, A.R., Gebremedhin, D., et al. Cytochrome P450 metabolites of arachidonic acid as intracellular signaling molecules in vascular tissue J. Vasc. Res. 34,237-243(1997).
2. Imig, J.D., Zou, A.P., Stec, D.E., et al. Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles Am. J. Physiol. 270,R217-R227(1996).
3. Nakamura, T., Kakinuma, H., Umemiya, H., et al. Imidazole derivatives as new potent and selective 20-HETE synthase inhibitor Bioorg. Med. Chem. Lett. 14,333-336(2004).

6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE Suppliers

China 12 United States 2 Global 14
BOC Sciences
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16314854226
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ShangHai Biochempartner Co.,Ltd
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DC Chemicals
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TargetMol Chemicals Inc.
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RD International Technology Co., Limited
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502656-68-0, 6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDERelated Search:

CAY10505 Benzamide, 4-(dimethylamino)-N-[3-[[2-[(4-oxo-4H-1-benzopyran-7-yl)oxy]acetyl]amino]phenyl]-

  • 6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE
  • CAY10462
  • 6-(4-imidazol-1-ylphenoxy)-N,N-dimethylhexan-1-amine:dihydrochloride
  • CAY10462 2HCl
  • CAY 10462 dihydrochloride
  • 502656-68-0