CAY10505
- Product Name
- CAY10505
- CAS No.
- 1218777-13-9
- Chemical Name
- CAY10505
- Synonyms
- CAY10505;CAY10505, >=98%;CAY10505 CAY-10505;CAY10505 USP/EP/BP;(E)-5-((5-(4-fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione;(5E)-5-[[5-(4-Fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione;2,4-Thiazolidinedione, 5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-, (5E)-;CAY10505 ( 5E)-5-[[5-(4-Fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
- CBNumber
- CB72561463
- Molecular Formula
- C14H8FNO3S
- Formula Weight
- 289.28
- MOL File
- 1218777-13-9.mol
CAY10505 Property
- Density
- 1.466
- storage temp.
- Store at -20°C
- solubility
- insoluble in EtOH; insoluble in H2O; ≥14.45 mg/mL in DMSO
- form
- solid
- pka
- 7.21±0.20(Predicted)
N-Bromosuccinimide Price
- Product number
- C226995
- Product name
- CAY10505
- Packaging
- 10mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-5662
- Product name
- CAY10505
- Purity
- 99.79%
- Packaging
- 10mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- B2182
- Product name
- CAY10505
- Packaging
- 25mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- CS-5662
- Product name
- CAY10505
- Purity
- 99.79%
- Packaging
- 25mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- KIN0001505
- Product name
- CAY-10505
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $135.45
- Updated
- 2021/12/16
CAY10505 Chemical Properties,Usage,Production
Uses
CAY10505 is a phosphoinositide 3-kinase gamma (PI3Kγ) specific inhibitor and improves hypertension-associated vascular endothelial dysfunction.
Biological Activity
cay10505 is a potent and selective pi3kγ inhibitor (ic50= 30 nm)pi3k (phosphatidylinositol-4,5-bisphosphate 3-kinase) is a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. it plays a key role in pi3k/akt/mtor pathway.in neurons treated with 3.5 μm ba, 200 nm cay10505 partially reduced the baicalein-induced akt phosphorylation. [1]in hypertensive rats, cay10505 at 0.6 mg.kg-1 p.o. exhibited the following effects 1) effectively reduced mabp; 2) significantly ameliorated vascular endothelium dysfunction in hypertensive rats in combination of doca; 3) prominently increased serum nitrite and/or nitrate concentrations.4) prevented hypertension-induced attenuation of ach-induced endothelium-dependent relaxation.[2]
References
[1] tyagi s, sharma s, budhiraja rd. effect of phosphatidylinositol 3-kinase-γ inhibitor cay10505 in hypertension, and its associated vascular endothelium dysfunction in rats. can j physiol pharmacol. 2012 jul;90(7):881-5.
[2] sun yy, lin sh, lin hc et al. cell type-specific dependency on the pi3k/akt signaling pathway for the endogenous epo and vegf induction by baicalein in neurons versus astrocytes. plos one. 2013 jul 19;8(7):e69019.
CAY10505 Preparation Products And Raw materials
Raw materials
Preparation Products
CAY10505 Suppliers
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- +86 (531) 88811783
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View Lastest Price from CAY10505 manufacturers
- Product
- (5E)-5-[[5-(4-fluorophenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione 1218777-13-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-20