CAY10505

ChemicalBook > CAS DataBase List > CAY10505

Product Name: CAY10505
CAS No.: 1218777-13-9
Chemical Name: CAY10505
Synonyms: CAY10505;CAY10505, >=98%;CAY10505 CAY-10505;CAY10505 USP/EP/BP;(E)-5-((5-(4-fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione;(5E)-5-[[5-(4-Fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione;2,4-Thiazolidinedione, 5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-, (5E)-;CAY10505 ( 5E)-5-[[5-(4-Fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
CBNumber: CB72561463
Molecular Formula: C14H8FNO3S
Formula Weight: 289.28
MOL File: 1218777-13-9.mol

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CAY10505 Property

Density: 1.466
storage temp.: Store at -20°C
solubility: insoluble in EtOH; insoluble in H2O; ≥14.45 mg/mL in DMSO
form: solid
pka: 7.21±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C226995
Product name: CAY10505
Packaging: 10mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-5662
Product name: CAY10505
Purity: 99.79%
Packaging: 10mg
Price: $50
Updated: 2021/12/16

ApexBio Technology

Product number: B2182
Product name: CAY10505
Packaging: 25mg
Price: $70
Updated: 2021/12/16

ChemScene

Product number: CS-5662
Product name: CAY10505
Purity: 99.79%
Packaging: 25mg
Price: $90
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0001505
Product name: CAY-10505
Purity: 95.00%
Packaging: 1MG
Price: $135.45
Updated: 2021/12/16

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CAY10505 Chemical Properties,Usage,Production

Uses

CAY10505 is a phosphoinositide 3-kinase gamma (PI3Kγ) specific inhibitor and improves hypertension-associated vascular endothelial dysfunction.

Biological Activity

cay10505 is a potent and selective pi3kγ inhibitor (ic50= 30 nm)pi3k (phosphatidylinositol-4,5-bisphosphate 3-kinase) is a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. it plays a key role in pi3k/akt/mtor pathway.in neurons treated with 3.5 μm ba, 200 nm cay10505 partially reduced the baicalein-induced akt phosphorylation. [1]in hypertensive rats, cay10505 at 0.6 mg.kg-1 p.o. exhibited the following effects 1) effectively reduced mabp; 2) significantly ameliorated vascular endothelium dysfunction in hypertensive rats in combination of doca; 3) prominently increased serum nitrite and/or nitrate concentrations.4) prevented hypertension-induced attenuation of ach-induced endothelium-dependent relaxation.[2]

References

[1] tyagi s, sharma s, budhiraja rd. effect of phosphatidylinositol 3-kinase-γ inhibitor cay10505 in hypertension, and its associated vascular endothelium dysfunction in rats. can j physiol pharmacol. 2012 jul;90(7):881-5.
[2] sun yy, lin sh, lin hc et al. cell type-specific dependency on the pi3k/akt signaling pathway for the endogenous epo and vegf induction by baicalein in neurons versus astrocytes. plos one. 2013 jul 19;8(7):e69019.

CAY10505 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from CAY10505 manufacturers

Career Henan Chemical Co

Product: (5E)-5-[[5-(4-fluorophenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione 1218777-13-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-20

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CAY10505

(5E)-5-[[5-(4-Fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione

(E)-5-((5-(4-fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione

CAY10505 ( 5E)-5-[[5-(4-Fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione

CAY10505, >=98%

2,4-Thiazolidinedione, 5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-, (5E)-

CAY10505 USP/EP/BP

CAY10505 CAY-10505

1218777-13-9

Akt

mTOR

PI3K

PI3K/Akt/mTOR

Inhibitors