3-BROMOPHENETOLE

3-BROMOPHENETOLE Property

Boiling point:

206 °C (lit.)

Density 

1.481 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.548(lit.)

Flash point:

182 °F

storage temp. 

Sealed in dry,Room Temperature

form 

clear liquid

color 

Colorless to Light yellow to Light orange

Specific Gravity

1.481

CAS DataBase Reference

2655-84-7(CAS DataBase Reference)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

WGK Germany 

3

HS Code 

2909309090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

3-BROMOPHENETOLE Chemical Properties,Usage,Production

Synthesis

General procedure for the synthesis of 3-ethoxybromobenzene: Sodium hydride (18.4 g, 60% oil dispersion, 460 mmol) was suspended in 1000 mL of DMF and the mixture was cooled to 0 °C. 3-Bromophenol (72 g, 419 mmol) was placed in a dropping funnel and heated using a hot air gun to melt it and then added dropwise to the cooled sodium hydride suspension. After the dropwise addition, the reaction mixture was continued to be stirred at 0 °C for 30 min. Subsequently, iodoethane (40 mL, 78 g, 503 mmol) was slowly added dropwise and the mixture was stirred for 12 hours, during which time it was allowed to warm naturally to room temperature. Upon completion of the reaction, water (1000 mL) was carefully added to quench the reaction, followed by extraction with ethyl acetate (4 x 500 mL). The organic layers were combined, washed with water (8 x 200 mL), dried over anhydrous sodium sulfate, filtered and concentrated. The residue was distilled under reduced pressure and the fractions with boiling points above 120 °C were collected to give 70 g of the target product 3-ethoxybromobenzene in 84% yield. The density of the product was 1.47 g/mL.

References

[1] Patent: US5914329, 1999, A
[2] Patent: EP944611, 2004, B1. Location in patent: Page 6-7
[3] Patent: US2018/290997, 2018, A1. Location in patent: Paragraph 0209