ChemicalBook > CAS DataBase List > (S)-2-{Bis[3,5-bis(trifluoromethyl)phenyl]hydroxymethyl}pyrrolidine
(S)-2-{Bis[3,5-bis(trifluoromethyl)phenyl]hydroxymethyl}pyrrolidine
- Product Name
- (S)-2-{Bis[3,5-bis(trifluoromethyl)phenyl]hydroxymethyl}pyrrolidine
- CAS No.
- 848821-76-1
- Chemical Name
- (S)-2-{Bis[3,5-bis(trifluoromethyl)phenyl]hydroxymethyl}pyrrolidine
- Synonyms
- (S)-α,α-Bis[3,5-bis(trifL;Bis(3,5-bis(trifluoroMethyl)phenyl)(pyrrolidin-2-yl)Methanol;2-Pyrrolidinemethanol, a,a-bis[3,5-bis(trifluoromethyl)pheny...;(S)-Bis(3,5-bis(trifluoromethyl)phenyl)(pyrrolidin-2-yl)methanol;(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol;(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol;(S)-(-)-α,α-bis[3,5-(trifluoromethyl)phenyl]-2-pyrrolidinemethanol;bis[3,5-bis(trifluoromethyl)phenyl]-[(2S)-pyrrolidin-2-yl]methanol;(S)-2-{Bis[3,5-bis(trifluoromethyl)phenyl]hydroxymethyl}pyrrolidine;2-PyrrolidineMethanol, a,a-bis[3,5-bis(trifluoroMethyl)phenyl]-, (2S)-
- CBNumber
- CB52091584
- Molecular Formula
- C21H15F12NO
- Formula Weight
- 525.33
- MOL File
- 848821-76-1.mol
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(S)-2-{Bis[3,5-bis(trifluoromethyl)phenyl]hydroxymethyl}pyrrolidine Property
- Melting point:
- 113-117 °C
- Boiling point:
- 391.8±42.0 °C(Predicted)
- Density
- 1.465±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 12.26±0.29(Predicted)
- form
- powder to crystal
- color
- White to Light yellow
- optical activity
- -52.535°(C=0.01g/ml CHCL3)
- InChI
- InChI=1/C21H15F12NO/c22-18(23,24)12-4-10(5-13(8-12)19(25,26)27)17(35,16-2-1-3-34-16)11-6-14(20(28,29)30)9-15(7-11)21(31,32)33/h4-9,16,34-35H,1-3H2/t16-/s3
- InChIKey
- ITXPGQOGEYWAKW-INIZCTEOSA-N
- SMILES
- C(F)(F)(C1=CC(C(O)(C2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)[C@@H]2CCCN2)=CC(=C1)C(F)(F)F)F |&1:22,r|
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Safety
- WGK Germany
- 3
- HS Code
- 2933.99.8290
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 670960
- Product name
- (S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol
- Purity
- ≥99.0%
- Packaging
- 1g
- Price
- $122
- Updated
- 2025/07/31
TCI Chemical
- Product number
- B5701
- Product name
- (S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $79
- Updated
- 2025/07/31
ChemScene
- Product number
- CS-0044515
- Product name
- (S)-Bis(3,5-bis(trifluoromethyl)phenyl)(pyrrolidin-2-yl)methanol
- Purity
- 98.78%
- Packaging
- 1g
- Price
- $41
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FS76244
- Product name
- (S)-alpha,alpha-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FS76244
- Product name
- (S)-alpha,alpha-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
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(S)-2-{Bis[3,5-bis(trifluoromethyl)phenyl]hydroxymethyl}pyrrolidine Chemical Properties,Usage,Production
Uses
(S)-2-{Bis[3,5-bis(trifluoromethyl)phenyl]hydroxymethyl}pyrrolidine is a chiral ligand, used in catalytic asymmetric synthesis. Its application extends to the production of propargylic sulfamidates and cyclic imines.
Synthesis
845965-28-8
848821-76-1
The general procedure for the synthesis of S-α,α-bis(3,5-bis-trifluoromethyl-phenyl)proline from the compound (CAS: 845965-28-8) was as follows: 4.3 g (76 mmol) of KOH and 4.2 g (7.6 mmol) of (S)-1,2-bis-(3,5-bis-trifluoromethyl-phenyl)-tetrahydro-pyrrolo[1,2-c]oxazole -3- was suspended in 20 mL of methanol and heated to reflux for 2 hours. After completion of the reaction, it was cooled to room temperature and the solvent was removed under reduced pressure. After addition of water, the mixture was extracted with dichloromethane. The organic phase was dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure to give 4.2 g (99% yield) of the target product as a colorless oil.
References
[1] Patent: WO2005/80298, 2005, A1. Location in patent: Page/Page column 31
(S)-2-{Bis[3,5-bis(trifluoromethyl)phenyl]hydroxymethyl}pyrrolidine Preparation Products And Raw materials
Raw materials
Preparation Products
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(S)-2-{Bis[3,5-bis(trifluoromethyl)phenyl]hydroxymethyl}pyrrolidine Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
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View Lastest Price from (S)-2-{Bis[3,5-bis(trifluoromethyl)phenyl]hydroxymethyl}pyrrolidine manufacturers
Career Henan Chemical Co
- Product
- (S)-2-{Bis[3,5-bis(trifluoromethyl)phenyl]hydroxymethyl}pyrrolidine 848821-76-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09
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