Uses Preparation
ChemicalBook > CAS DataBase List > (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol

Uses Preparation
Product Name
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
CAS No.
127852-28-2
Chemical Name
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Synonyms
C1oHgF6O;R-MBT-PEL;(R)-1-[3,5-Bis(trifL;Aprepitant Impurity 49;Phenol,5-iodo-4-methyl-;Fosaprepitant Impurity 25;Rolapitant Intermediate 3;Thiazole,2-bromo-9-methyl-;(R)-1-[3,5- Bis(trifluoromethyl)phenyl]et;(R)-BIS-3,5-TRIFLUOROMETHYL-1-PHENYLETHANOL
CBNumber
CB5113482
Molecular Formula
C10H8F6O
Formula Weight
258.16
MOL File
127852-28-2.mol
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(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Property

Melting point:
53-58℃
Boiling point:
175.8±35.0 °C(Predicted)
Density 
1.376±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Acetonitrile (Slightly), Chloroform (Slightly)
pka
13.99±0.20(Predicted)
form 
Powder
color 
White
optical activity
[α]/D +27±1°, c = 1 in acetonitrile
λmax
272nm(MeOH)(lit.)
InChIKey
MMSCIQKQJVBPIR-RXMQYKEDSA-N
CAS DataBase Reference
127852-28-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-52/53-22
Safety Statements 
26-36/37/39-61
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29062990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
49554
Product name
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Purity
≥98.0% (GC)
Packaging
5g
Price
$72
Updated
2023/06/20
Sigma-Aldrich
Product number
49554
Product name
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Purity
≥98.0% (GC)
Packaging
25g
Price
$216
Updated
2023/06/20
TCI Chemical
Product number
B4131
Product name
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Purity
>98.0%(GC)
Packaging
5g
Price
$66
Updated
2024/03/01
TCI Chemical
Product number
B4131
Product name
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Purity
>98.0%(GC)
Packaging
25g
Price
$213
Updated
2024/03/01
Alfa Aesar
Product number
H60893
Product name
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol, 98%
Packaging
5g
Price
$73.08
Updated
2023/01/06
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(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Chemical Properties,Usage,Production

Uses

(R)-[3,5-bis (trifluoromethyl) phenyl] ethanol is an important chiral intermediate for the synthesis of novel chemotherapeutic and antiemetic drugs NK-1 receptor antagonists. Antidepressants have good potential efficacy in treating a range of central and peripheral nervous system depressions.

Preparation

At present, the methods for preparing optically pure (R)-[3,5-bis (trifluoromethyl) phenyl] ethanol include chemical methods and biological methods. Chemical synthesis requires the use of expensive transition metal Ru and other chemical catalysts, complicated steps, harsh reaction conditions, high energy consumption, large pollution, and low yield. Biological law is the use of free enzymes or whole cells for catalytic preparation. It has the characteristics of mild reaction conditions, high catalytic efficiency, and strong specificity.

Chemical Properties

White fine crystalline powder

Uses

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is an intermediate in the synthesis of Aprepitant (A729800), a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.

General Description

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is a key intermediate for the synthesis of aprepitant, a potent human neurokinin-1 (NK-1) receptor.

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Suppliers

Ningbo biermann pharmaceutical technology co., LTD
Tel
0571-82572971 13736400971
Fax
0574-87703432
Email
bichem.sales01@bichem.cn
Country
China
ProdList
47
Advantage
58
Chiral Quest (Suzhou) Co., Ltd.
Tel
0512-62956066 18112603058
Email
kendoll@cqpharm.com
Country
China
ProdList
82
Advantage
58
Ningbo Enzyme Chemical Co., LTD
Tel
+86-574-8773-0716-654 18042089573
Email
yufang.jiang@enzymaster.com
Country
China
ProdList
34
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Enantiotech Corporation Ltd
Tel
760-85282375 13212762451
Email
marketing@enantiotech.net
Country
China
ProdList
153
Advantage
55
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
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View Lastest Price from (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
(R)-1-[3,5-Bis(trilfuoromethyl)phenyl]ethanol 127852-28-2
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-09
Hebei Dangtong Import and export Co LTD
Product
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol 127852-28-2
Price
US $300.00-250.00/kg
Min. Order
100kg
Purity
99.99%
Supply Ability
100Tons
Release date
2023-03-06
Hebei Chuanghai Biotechnology Co,.LTD
Product
(R)-1-[3,5-Bis(trilfuoromethyl)phenyl]ethanol 127852-28-2
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-19

127852-28-2, (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanolRelated Search:


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  • (αR)-α-Methyl-3,5-bis(trifluoromethyl)benzenemethanol
  • (alphaR)-alpha-Methyl-3,5-bis(trifluoromethyl)-benzenemethanol
  • C1oHgF6O
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  • C10H8F7O
  • C10H8OF6
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  • Chiral Compounds
  • 127852-28-2