(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol

Uses Preparation

Product Name: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
CAS No.: 127852-28-2
Chemical Name: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Synonyms: C1oHgF6O;R-MBT-PEL;(R)-1-[3,5-Bis(trifL;Aprepitant Impurity 49;Phenol,5-iodo-4-methyl-;Fosaprepitant Impurity 25;Rolapitant Intermediate 3;Thiazole,2-bromo-9-methyl-;(R)-1-[3,5- Bis(trifluoromethyl)phenyl]et;(R)-BIS-3,5-TRIFLUOROMETHYL-1-PHENYLETHANOL
CBNumber: CB5113482
Molecular Formula: C10H8F6O
Formula Weight: 258.16
MOL File: 127852-28-2.mol

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(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Property

Melting point:: 53-58℃
Boiling point:: 175.8±35.0 °C(Predicted)
Density: 1.376±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: Acetonitrile (Slightly), Chloroform (Slightly)
pka: 13.99±0.20(Predicted)
form: Powder
color: White
optical activity: [α]/D +27±1°, c = 1 in acetonitrile
λmax: 272nm(MeOH)(lit.)
InChIKey: MMSCIQKQJVBPIR-RXMQYKEDSA-N
CAS DataBase Reference: 127852-28-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-52/53-22
Safety Statements: 26-36/37/39-61
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29062990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 49554
Product name: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Purity: ≥98.0% (GC)
Packaging: 5g
Price: $72
Updated: 2023/06/20

Sigma-Aldrich

Product number: 49554
Product name: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Purity: ≥98.0% (GC)
Packaging: 25g
Price: $216
Updated: 2023/06/20

TCI Chemical

Product number: B4131
Product name: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Purity: >98.0%(GC)
Packaging: 5g
Price: $66
Updated: 2024/03/01

TCI Chemical

Product number: B4131
Product name: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Purity: >98.0%(GC)
Packaging: 25g
Price: $213
Updated: 2024/03/01

Alfa Aesar

Product number: H60893
Product name: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol, 98%
Packaging: 5g
Price: $73.08
Updated: 2023/01/06

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(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Chemical Properties,Usage,Production

Uses

(R)-[3,5-bis (trifluoromethyl) phenyl] ethanol is an important chiral intermediate for the synthesis of novel chemotherapeutic and antiemetic drugs NK-1 receptor antagonists. Antidepressants have good potential efficacy in treating a range of central and peripheral nervous system depressions.

Preparation

At present, the methods for preparing optically pure (R)-[3,5-bis (trifluoromethyl) phenyl] ethanol include chemical methods and biological methods. Chemical synthesis requires the use of expensive transition metal Ru and other chemical catalysts, complicated steps, harsh reaction conditions, high energy consumption, large pollution, and low yield. Biological law is the use of free enzymes or whole cells for catalytic preparation. It has the characteristics of mild reaction conditions, high catalytic efficiency, and strong specificity.

Chemical Properties

White fine crystalline powder

Uses

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is an intermediate in the synthesis of Aprepitant (A729800), a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.

General Description

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is a key intermediate for the synthesis of aprepitant, a potent human neurokinin-1 (NK-1) receptor.

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Suppliers

Americas 1 Canada 1 China 345 Europe 2 France 1 Germany 7 India 20 Japan 5 Singapore 1 Switzerland 2 The Netherlands 1 United Kingdom 9 United States 40 Global 435

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

Central Glass Co., Ltd.

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Email: info_fineglass@cgco.co.jp
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Fine Corporation

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Hattori Corporation

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Country: Japan
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Central Glass Co. Ltd.

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Email: fcsd@cgco.co.jp
Country: Japan
ProdList: 194
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View Lastest Price from (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol manufacturers

Hebei Dangtong Import and export Co LTD

Product: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol 127852-28-2
Price: US $300.00-250.00/kg
Min. Order: 100kg
Purity: 99.99%
Supply Ability: 100Tons
Release date: 2023-03-06

Hebei Chuanghai Biotechnology Co,.LTD

Product: (R)-1-[3,5-Bis(trilfuoromethyl)phenyl]ethanol 127852-28-2
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-19

Hangzhou ICH Biofarm Co., Ltd

Product: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol 127852-28-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: ≥1kg
Release date: 2023-07-18

127852-28-2, (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanolRelated Search:

2-AMINO-1-PHENYLETHANOL Diphenyl ether Chlorodimethylphenylsilane Phenyl salicylate Ethanol Silicone oil (high temperature) N-Methyldiethanolamine Ethyl acetate PHENYL VALERATE 2-Methylaminoethanol Phenethyl alcohol PHENYL RESIN methylphenyl silicone resin 2-(R)-[1-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy]-3-(S)-fluorophenylmorpholine 2-[3,5-Bis(trifluoromethyl)phenyl]propan-2-ol 2-Dimethylaminoethanol (S)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL,(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL Aprepitant

(R)-BIS-3,5-TRIFLUOROMETHYL-1-PHENYLETHANOL

Rolapitant Intermediate 3

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol127852-28-2

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol,99%e.e.

Fosaprepitant Impurity 25

Aprepitant Impurity 49

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol （Aprepitant）

(R)-1-[3,5-BIS(TRIFLUORO-METHYL)-PHENYL]ETHANOL 98%

(1R)-1-[3,6-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL

R-MBT-PEL

(R)-1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)ETHAN-1-OL

(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL

(R)-1-[BIS-3,5-(TRIFLUOROMETHYL)PHENYL]ETHANOL

Benzenemethanol, a-methyl-3,5-bis(trifluoromethyl)-, (aR)-

(1R)-(+)-1-[3,5-Bis(trifluoromethyl)phenyl]ethan-1-ol

(R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethanol >=98.0% (GC)

Benzenemethanol, .alpha.-methyl-3,5-bis(trifluoromethyl)-, (.alpha.R)-

(R)-1-[3,5-Bis(trifluoromethyl) phenyl]ethanol,Aprepitant intermediate

(R)-1-[3,5-Bis(trilfuoromethyl)phenyl]ethanol

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol &gt

(R)-1-[3,5-di (trifluoromethyl) phenyl] ethanol

(R)-1-[3,5-Bis(trifL

Benzenemethanol, α-methyl-3,5-bis(trifluoromethyl)-, (αR)-

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethyl Alcohol

(R)-3,5-Bis(trifluoromethyl)-alpha-methylbenzyl Alcohol

Aprepitant intermediates，(R)-1-[3,5- Bis(trifluoromethyl)phenyl]ethanol

?-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol, 98%,

(R)-1-[3,5-Bis(trifluoromethyl)phenyi]ethanol

Thiazole,2-bromo-9-methyl-

Phenol,5-iodo-4-methyl-

Benzenemethanol,α-methyl-3,5-bis(trifluoromethyl)-,(αR)-

(S)-1-(3,5-Bi(trifluoromethyl)phenyl)ethan-1-ol

(αR)-α-Methyl-3,5-bis(trifluoromethyl)benzenemethanol

(alphaR)-alpha-Methyl-3,5-bis(trifluoromethyl)-benzenemethanol

C1oHgF6O

(R)-l-(3,5-bis(trifluorom ethyl)pheny l)ethan-1 -ol

(R)-1-[3,5- Bis(trifluoromethyl)phenyl]et

127852-28-2

C10H8F7O

C10H8OF6

API intermediates

Alcohols, Hydroxy Esters and Derivatives

Chiral Compounds

127852-28-2