(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol

ChemicalBook > CAS DataBase List > (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol

Uses Preparation

Product Name: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
CAS No.: 127852-28-2
Chemical Name: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Synonyms: C1oHgF6O;R-MBT-PEL;(R)-1-[3,5-Bis(trifL;Aprepitant Impurity 49;Phenol,5-iodo-4-methyl-;Fosaprepitant Impurity 25;Rolapitant Intermediate 3;Thiazole,2-bromo-9-methyl-;(R)-1-[3,5- Bis(trifluoromethyl)phenyl]et;(R)-BIS-3,5-TRIFLUOROMETHYL-1-PHENYLETHANOL
CBNumber: CB5113482
Molecular Formula: C10H8F6O
Formula Weight: 258.16
MOL File: 127852-28-2.mol

Less

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Property

Melting point:: 53-58℃
Boiling point:: 175.8±35.0 °C(Predicted)
Density: 1.376±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: Acetonitrile (Slightly), Chloroform (Slightly)
pka: 13.99±0.20(Predicted)
form: Powder
color: White
optical activity: [α]/D +27±1°, c = 1 in acetonitrile
λmax: 272nm(MeOH)(lit.)
InChIKey: MMSCIQKQJVBPIR-RXMQYKEDSA-N
CAS DataBase Reference: 127852-28-2(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-52/53-22
Safety Statements: 26-36/37/39-61
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29062990

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 49554
Product name: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Purity: ≥98.0% (GC)
Packaging: 5g
Price: $72
Updated: 2023/06/20

Sigma-Aldrich

Product number: 49554
Product name: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Purity: ≥98.0% (GC)
Packaging: 25g
Price: $216
Updated: 2023/06/20

TCI Chemical

Product number: B4131
Product name: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Purity: >98.0%(GC)
Packaging: 5g
Price: $66
Updated: 2024/03/01

TCI Chemical

Product number: B4131
Product name: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Purity: >98.0%(GC)
Packaging: 25g
Price: $213
Updated: 2024/03/01

Alfa Aesar

Product number: H60893
Product name: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol, 98%
Packaging: 5g
Price: $73.08
Updated: 2023/01/06

Less

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Chemical Properties,Usage,Production

Uses

(R)-[3,5-bis (trifluoromethyl) phenyl] ethanol is an important chiral intermediate for the synthesis of novel chemotherapeutic and antiemetic drugs NK-1 receptor antagonists. Antidepressants have good potential efficacy in treating a range of central and peripheral nervous system depressions.

Preparation

At present, the methods for preparing optically pure (R)-[3,5-bis (trifluoromethyl) phenyl] ethanol include chemical methods and biological methods. Chemical synthesis requires the use of expensive transition metal Ru and other chemical catalysts, complicated steps, harsh reaction conditions, high energy consumption, large pollution, and low yield. Biological law is the use of free enzymes or whole cells for catalytic preparation. It has the characteristics of mild reaction conditions, high catalytic efficiency, and strong specificity.

Chemical Properties

White fine crystalline powder

Uses

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is an intermediate in the synthesis of Aprepitant (A729800), a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.

General Description

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is a key intermediate for the synthesis of aprepitant, a potent human neurokinin-1 (NK-1) receptor.

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Preparation Products And Raw materials

Raw materials

Preparation Products

Less

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Suppliers

Americas 1 Canada 1 China 345 Europe 2 France 1 Germany 7 India 20 Japan 5 Singapore 1 Switzerland 2 The Netherlands 1 United Kingdom 9 United States 40 Global 435

Ningbo biermann pharmaceutical technology co., LTD

Tel: 0571-82572971 13736400971
Fax: 0574-87703432
Email: bichem.sales01@bichem.cn
Country: China
ProdList: 47
Advantage: 58

Chiral Quest (Suzhou) Co., Ltd.

Tel: 0512-62956066 18112603058
Email: kendoll@cqpharm.com
Country: China
ProdList: 82
Advantage: 58

Ningbo Enzyme Chemical Co., LTD

Tel: +86-574-8773-0716-654 18042089573
Email: yufang.jiang@enzymaster.com
Country: China
ProdList: 34
Advantage: 58

Nanjing Tianyuexing Bio-tech Co.,Ltd.

Tel: 吴学平13585175604 13585175604
Email: wangxingyu@chicopharm.com
Country: China
ProdList: 256
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44688
Advantage: 61

Enantiotech Corporation Ltd

Tel: 760-85282375 13212762451
Email: marketing@enantiotech.net
Country: China
ProdList: 184
Advantage: 55

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 18207
Advantage: 66

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9499
Advantage: 66

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

Anhui Lianchuang Biological Medicine Co.,Ltd

Tel: 0551-68779238 18056025720
Email: sales3@lcywhx.com
Country: China
ProdList: 159
Advantage: 57

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11655
Advantage: 64

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 19172
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8838
Advantage: 52

Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
Fax: +86-21-50462321
Email: han_yajun@dctc.daicel.com
Country: China
ProdList: 7191
Advantage: 65

Changzhou Kangte Pharmtech Co.,Ltd

Tel: 0519-82813797 18994752886
Fax: 0519-82813703
Email: czkangte@hotmail.com
Country: China
ProdList: 45
Advantage: 62

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Shanghai Aobo pharmaceutical Technology Co., Ltd

Tel: 86-21-51320499
Fax: 86-21-51320368
Email: aobo@aobopharm.com
Country: China
ProdList: 297
Advantage: 57

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11707
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 4552
Advantage: 62

Nanjing Vital Chemical Co., Ltd.

Tel: Please Send Email 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
ProdList: 4378
Advantage: 65

Aemon Chemical

Tel: 0086-755-86198205
Email: acinfo@aemonchem.com
Country: China
ProdList: 1931
Advantage: 57

Shanghai Holy Biohemdeviser Co., Ltd

Tel: 021-61551100
Fax: 021-61551100
Country: China
ProdList: 444
Advantage: 57

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 9387
Advantage: 52

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-59207852 13308628970
Fax: QQ3130921841
Email: buy@fortunachem.com
Country: China
ProdList: 2871
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Moltt Biocem Co., Ltd.

Tel: +86-21-38682181 15900741819
Fax: +86-21-38682181
Country: China
ProdList: 282
Advantage: 55

Syncozymes (Shanghai) Co.,Ltd.

Tel: 021-68187180-819 13681683526
Fax: 021-68187179
Email: lchen@syncozymes.com
Country: China
ProdList: 225
Advantage: 55

China Nobel Chem Co., Limited

Tel: +86(0)21 60484900
Fax: +86(0)21 60484900
Country: China
ProdList: 764
Advantage: 50

Hunan Furui Biopharma Technology Co., Ltd.

Tel: 15902102743
Fax: 0731-57805668
Email: shelley@furuipharma.com
Country: China
ProdList: 452
Advantage: 55

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3239
Advantage: 55

AllyChem Co., Ltd.

Tel: 0411-62313318 13942603642
Fax: 0411-87549748
Email: info@allychem.com
Country: China
ProdList: 928
Advantage: 65

DONGSHENG CHIRAL PHARMA

Tel: 18051538752
Email: 3755454181@qq.com
Country: China
ProdList: 432
Advantage: 55

Zhongshan Haihong Medicine Co. Ltd

Tel: 0760-86925768 18824993998
Fax: 0760-86925770
Email: seas168@126.com
Country: China
ProdList: 60
Advantage: 58

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9978
Advantage: 55

Taizhou Tongxin Bio-Tech Co., Ltd

Tel: 0523-18601685-898 18652728585
Email: sales@allyrise.com
Country: China
ProdList: 2773
Advantage: 60

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41462
Advantage: 60

Shanghai DiBai Chemicals Co., Ltd.

Tel: 021-54359730 400-008-9730
Fax: 021-54353864
Email: info@chemxyz.com
Country: China
ProdList: 3991
Advantage: 60

Less

View Lastest Price from (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol manufacturers

Hebei Dangtong Import and export Co LTD

Product: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol 127852-28-2
Price: US $300.00-250.00/kg
Min. Order: 100kg
Purity: 99.99%
Supply Ability: 100Tons
Release date: 2023-03-06

Hebei Chuanghai Biotechnology Co,.LTD

Product: (R)-1-[3,5-Bis(trilfuoromethyl)phenyl]ethanol 127852-28-2
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-19

Hangzhou ICH Biofarm Co., Ltd

Product: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol 127852-28-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: ≥1kg
Release date: 2023-07-18

127852-28-2, (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanolRelated Search:

2-AMINO-1-PHENYLETHANOL Diphenyl ether Chlorodimethylphenylsilane Phenyl salicylate Ethanol Silicone oil (high temperature) N-Methyldiethanolamine Ethyl acetate PHENYL VALERATE 2-Methylaminoethanol Phenethyl alcohol PHENYL RESIN methylphenyl silicone resin 2-(R)-[1-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy]-3-(S)-fluorophenylmorpholine 2-[3,5-Bis(trifluoromethyl)phenyl]propan-2-ol 2-Dimethylaminoethanol (S)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL,(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL Aprepitant

(R)-BIS-3,5-TRIFLUOROMETHYL-1-PHENYLETHANOL

Rolapitant Intermediate 3

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol127852-28-2

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol,99%e.e.

Fosaprepitant Impurity 25

Aprepitant Impurity 49

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol （Aprepitant）

(R)-1-[3,5-BIS(TRIFLUORO-METHYL)-PHENYL]ETHANOL 98%

(1R)-1-[3,6-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL

R-MBT-PEL

(R)-1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)ETHAN-1-OL

(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL

(R)-1-[BIS-3,5-(TRIFLUOROMETHYL)PHENYL]ETHANOL

Benzenemethanol, a-methyl-3,5-bis(trifluoromethyl)-, (aR)-

(1R)-(+)-1-[3,5-Bis(trifluoromethyl)phenyl]ethan-1-ol

(R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethanol >=98.0% (GC)

Benzenemethanol, .alpha.-methyl-3,5-bis(trifluoromethyl)-, (.alpha.R)-

(R)-1-[3,5-Bis(trifluoromethyl) phenyl]ethanol,Aprepitant intermediate

(R)-1-[3,5-Bis(trilfuoromethyl)phenyl]ethanol

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol &gt

(R)-1-[3,5-di (trifluoromethyl) phenyl] ethanol

(R)-1-[3,5-Bis(trifL

Benzenemethanol, α-methyl-3,5-bis(trifluoromethyl)-, (αR)-

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethyl Alcohol

(R)-3,5-Bis(trifluoromethyl)-alpha-methylbenzyl Alcohol

Aprepitant intermediates，(R)-1-[3,5- Bis(trifluoromethyl)phenyl]ethanol

?-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol, 98%,

(R)-1-[3,5-Bis(trifluoromethyl)phenyi]ethanol

Thiazole,2-bromo-9-methyl-

Phenol,5-iodo-4-methyl-

Benzenemethanol,α-methyl-3,5-bis(trifluoromethyl)-,(αR)-

(S)-1-(3,5-Bi(trifluoromethyl)phenyl)ethan-1-ol

(αR)-α-Methyl-3,5-bis(trifluoromethyl)benzenemethanol

(alphaR)-alpha-Methyl-3,5-bis(trifluoromethyl)-benzenemethanol

C1oHgF6O

(R)-l-(3,5-bis(trifluorom ethyl)pheny l)ethan-1 -ol

(R)-1-[3,5- Bis(trifluoromethyl)phenyl]et

127852-28-2

C10H8F7O

C10H8OF6

API intermediates

Alcohols, Hydroxy Esters and Derivatives

Chiral Compounds

127852-28-2