1-(tert-Butoxycarbonyl)-3-formyl-7-azaindole, 3-Formyl-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester

Product Name: 1-(tert-Butoxycarbonyl)-3-formyl-7-azaindole, 3-Formyl-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester
CAS No.: 144657-66-9
Chemical Name: 1-(tert-Butoxycarbonyl)-3-formyl-7-azaindole, 3-Formyl-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester
Synonyms: 1-Boc-3-formyl-7-azaindole;1-Boc-7-azaindole-3-carboxaldehyde;1-(tert-Butyloxycarbonyl)-3-formyl-7-azaindole;tert-Butyl 3-formyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate;TERT-BUTYL 3-FORMYL-1H-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLATEr;1-(tert-Butoxycarbonyl)-3-formyl-7-azaindole, 3-Formyl-pyrro...;1H-Pyrrolo[2,3-b]pyridine-1-carboxylic acid, 3-formyl-, 1,1-dimethylethyl ester;1-(tert-Butoxycarbonyl)-3-formyl-7-azaindole, 3-Formyl-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester
CBNumber: CB52097041
Molecular Formula: C13H14N2O3
Formula Weight: 246.26
MOL File: 144657-66-9.mol

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1-(tert-Butoxycarbonyl)-3-formyl-7-azaindole, 3-Formyl-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester Property

Melting point:: 124-129 °C
Boiling point:: 389.6±45.0 °C(Predicted)
Density: 1.20±0.1 g/cm3(Predicted)
storage temp.: 2-8°C, stored under nitrogen
pka: 1.35±0.30(Predicted)
form: powder
Appearance: White to off-white Solid

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Safety

Hazard Codes: Xn
Risk Statements: 22-43
Safety Statements: 36/37
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 696811
Product name: 1-Boc-7-azaindole-3-carboxaldehyde
Packaging: 1g
Price: $176
Updated: 2023/06/20

TRC

Product number: B695285
Product name: tert-Butyl3-Formyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
Packaging: 500mg
Price: $175
Updated: 2021/12/16

Matrix Scientific

Product number: 056455
Product name: tert-Butyl 3-formyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
Purity: >95%
Packaging: 1g
Price: $151
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 35648
Product name: tert-Butyl3-formyl-1H-pyrrolo[2,3-β]pyridine-1-carboxylate
Purity: 95+%
Packaging: 1g
Price: $510
Updated: 2021/12/16

AK Scientific

Product number: 7135AA
Product name: tert-Butyl3-formyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
Packaging: 250mg
Price: $103
Updated: 2021/12/16

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1-(tert-Butoxycarbonyl)-3-formyl-7-azaindole, 3-Formyl-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production

Chemical Properties

Beige powder

Uses

tert-Butyl 3-Formyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate is a useful reagent in study of eletrophilic fragment-based design of reversible covalent kinase inhibitors.

Synthesis

4649-09-6

24424-99-5

144657-66-9

To a round bottom flask was added 1H-pyrrolo[2,3-B]pyridine-3-carboxaldehyde (6.6 g, 45 mmol), di-tert-butyl dicarbonate (10.7 g, 50 mmol), 4-dimethylaminopyridine (55 mg, 0.45 mmol), and triethylamine (13 g, 130 mmol), followed by methylene chloride (50 mL). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the mixture was concentrated to dryness and purified by fast column chromatography to afford the target product 1-Boc-7-azaindole-3-carbaldehyde (9.8 g, 89% yield).

References

[1] Patent: WO2011/23081, 2011, A1. Location in patent: Page/Page column 55
[2] Patent: WO2017/37116, 2017, A1. Location in patent: Page/Page column 143
[3] Canadian Journal of Chemistry, 1992, vol. 70, # 5, p. 1531 - 1536
[4] Patent: WO2011/20193, 2011, A1. Location in patent: Page/Page column 36
[5] Patent: WO2013/45516, 2013, A1. Location in patent: Page/Page column 129; 197

1-(tert-Butoxycarbonyl)-3-formyl-7-azaindole, 3-Formyl-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(tert-Butoxycarbonyl)-3-formyl-7-azaindole, 3-Formyl-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester Suppliers

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View Lastest Price from 1-(tert-Butoxycarbonyl)-3-formyl-7-azaindole, 3-Formyl-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester manufacturers

Career Henan Chemical Co

Product: TERT-BUTYL 3-FORMYL-1H-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLATE 144657-66-9
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-21

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144657-66-9