Nelfinavir mesylate

ChemicalBook > CAS DataBase List > Nelfinavir mesylate

Product Name: Nelfinavir mesylate
CAS No.: 159989-65-8
Chemical Name: Nelfinavir mesylate
Synonyms: viracept;Nelfin;AG-1343;Nelfinavir1;Nelfinavir-d9;AG1343 Mesylate;AG 1343 Mesylate;AG-1343 Mesylate;NELFINAVIR MESYLATE;Nelfinavir nesylate
CBNumber: CB5213805
Molecular Formula: C33H49N3O7S2
Formula Weight: 663.89
MOL File: 159989-65-8.mol

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Nelfinavir mesylate Property

Melting point:: 131-135°C
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: DMSO: ≥2mg/mL
pka: pKa -1.20(at 25℃)
form: powder
color: white to off-white
Water Solubility: 4.5g/L(temperature not stated)
Merck: 14,6443
BCS Class: 2,4
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey: NQHXCOAXSHGTIA-SKXNDZRYSA-N
CAS DataBase Reference: 159989-65-8(CAS DataBase Reference)

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Safety

WGK Germany: 3
RTECS: NW6995333
HS Code: 29334900
Hazardous Substances Data: 159989-65-8(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0013
Product name: Nelfinavir mesylate hydrate
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: PZ0013
Product name: Nelfinavir mesylate hydrate
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $470
Updated: 2024/03/01

TCI Chemical

Product number: N0986
Product name: Nelfinavir Mesylate Hydrate
Purity: >97.0%(HPLC)
Packaging: 25mg
Price: $233
Updated: 2024/03/01

TCI Chemical

Product number: N0986
Product name: Nelfinavir Mesylate Hydrate
Purity: >97.0%(HPLC)
Packaging: 100mg
Price: $415
Updated: 2024/03/01

Cayman Chemical

Product number: 15144
Product name: Nelfinavir (mesylate)
Purity: ≥98%
Packaging: 5mg
Price: $57
Updated: 2024/03/01

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Nelfinavir mesylate Chemical Properties,Usage,Production

Description

Viracept was launched in the US as an orally-available, non-peptidic HIV protease inhibitor. It is prepared in an eight step synthesis beginning with N- (benzyloxycarbonyl)-L-serine β-lactone. The HIV protease inhibitory activity blocks the processing of gag and gagpol polyproteins that are required for viral maturation. It was discovered based on an experimentally derived 3D-structure of HIV-1 protease. Viracept has a high oral bioavailability, lacks toxicity, and has a resistance profile different from other protease inhibitors. Viracept with ziduvudine and larnivudine generated a 98% mean reduction from baseline in viral load after 24 weeks compared to ziduvudine and larnivudine alone. Viracept also had better CD4 counts and is available in adult and pediatric formulations.

Chemical Properties

White Powder

Originator

Agouron (US)

Uses

Nelfinavir Mesylate is an antiviral. HIV protease inhibitor. It is a COVID19-related research product.

Definition

ChEBI: A methanesulfonate (mesylate) salt prepared from equimolar amounts of nelfinavir and methanesulfonic acid. It is used for treatment of HIV and also exhibits some anticancer properties.

brand name

Viracept (Agouron).

Biological Activity

Orally active human immunodeficiency virus protease inhibitor. Potently inhibits HIV-1 protease (K i = 2 nM) in vitro .

Biochem/physiol Actions

Nelfinavir mesylate hydrate, also known as AG1343, is used as a therapeutic agent for acquired immunodeficiency syndrome (AIDS). It acts as an antifibrotic agent and is used to treat pulmonary fibrosis in patients with systemic sclerosis (SSc). In addition, nelfinavir mesylate hydrate reduces inflammation by activating protein phosphatase 2 (PP-2) and blocking mitogen-activated protein kinases (MAPK) signaling in macrophages. It also stimulate autophagy and exhibit anti-cancer property.

storage

Store at +4°C

References

1) Olmo?et al.?(2006),?A review of nelfinavir for the treatment of HIV infection; Expert Opin. Drug Metab. Toxicol.,?2?285 2) Bruning?et al.?(2010),?New prospects for nelfinavir in non-HIV-related diseases; Curr. Mol. Pharmacol.,?3?91 3) Gills?et al.?(2007),?Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo; Clin. Cancer Res,?13?5183 4) Shim?et al. (2012),?Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir; J. Natl. Cancer Inst,,?104?1576

Nelfinavir mesylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Nelfinavir mesylate manufacturers

Career Henan Chemical Co

Product: Nelfinavir mesylate 159989-65-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000KGS
Release date: 2020-01-02

159989-65-8, Nelfinavir mesylateRelated Search:

Gatifloxacin mesylate Trifluoromethanesulfonic acid Butylated hydroxyanisole Imatinib Butylated Hydroxytoluene Pazufloxacin mesilate Pefloxacin mesylate CIS-HEPTACHLOREPOXIDE EXO-, ISOMER B tert-Butylchlorodiphenylsilane Levofloxacin Methylate tert-Butyl methyl ether Phentolamine mesilate Methanesulfonic acid Hydroxy silicone oil butyl rubber CHLOROPHOSPHONAZO III Phenylacetone NELFINAVIR

8a-beta))-a-betmonomethanesulfonate(salt)

droxy-2-methylbenzoyl)amino)-4-(phenylthio)butyl)-,(3s-(2(2,s*,3s*),3-alpha,4

viracept

3-Isoquinolinecarboxamide, N-(1,1-dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-, (3S,4aS,8aS)-, methanesulfonate (1:1)

(3S,4AS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl

NELFINAVIR MESYLATE

AG-1343

(3s,4as,8as)-n-(1,1-dimethylethyl)decahydro-2-[(2r,3r)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide mesylate

NELFINAVIRMESYLATE(SUBJECTTOPATENTFREE)

Nelfinavir nesylate

(3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamidemethanesulfonate

Nelfinavir Mesylate (200 mg)

Nelfin

Nelfinavir (Methanesulfonate)

AG 1343 Mesylate

AG1343 Mesylate

AG-1343 Mesylate

Nelfinavir1

(3S,4aS,8aS)-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methyl-benzoyl)amino]-4-phenylsulfanyl-butyl]-N-tert-butyl-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide

N-(1,1-dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-(3S,4aS,8aS)-3-isoquinolinecarboxamide, methanesulfonate (1:1)

Nelfinavir mesylate hydrate

Nelfinavir methanesulfonate hydrate

Nelfinavir mesylate, >=98%

Nelfinavir-d9

(3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[[(3-hydroxy-2-methylphenyl)-oxomethyl]amino]-4-(phenylthio)butyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide

Nelfinavir Mesylate (AG 1343 Mesylate)

Nelfinavir mesylate - AG 1343

AG 1343 MESYLATE;AG1343 MESYLATE;AG-1343 MESYLATE

(3S,4aS,8aS)-N-(tert-Butyl)-2-((2R,3R)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-4-(phenylthio)butyl)decahydroisoquinoline-3-carboxamide methanesulfonate

Nelfinavir MesylateQ: What is Nelfinavir Mesylate Q: What is the CAS Number of Nelfinavir Mesylate Q: What is the storage condition of Nelfinavir Mesylate Q: What are the applications of Nelfinavir Mesylate

Glumetinib Impurity 2

159989-65-8

C32H45N3O4SCH4O3SxH2O

C32H45N3O4S

C33H49N3O7S2

C32H45N3O4SCH4O2S2

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peptides

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Non-nucleoside Reverse Transcriptase

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