ChemicalBook > CAS DataBase List > Heptafluorobutyric anhydride

Heptafluorobutyric anhydride

Product Name
Heptafluorobutyric anhydride
CAS No.
336-59-4
Chemical Name
Heptafluorobutyric anhydride
Synonyms
HFAA;PERFLUOROBUTYRIC ANHYDRIDE;2,2,3,3,4,4,4-heptafluorobutanoic anhydride;AKOS B020344;uorobutyric anhydride;Heptafluorotic anhydride;Perfluorobutanoic anhydride;HEPTAFLUOROBUTYRIC ANHYDRIDE;PERFLUORO-N-BUTYRIC ANHYDRIDE;Heptafluorobutanoic anhydride
CBNumber
CB5217287
Molecular Formula
C8F14O3
Formula Weight
410.06
MOL File
336-59-4.mol
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Heptafluorobutyric anhydride Property

Melting point:
−43 °C(lit.)
Boiling point:
108-110 °C(lit.)
Density 
1.674 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.287(lit.)
Flash point:
None
storage temp. 
room temp
solubility 
Miscible with halogenated solvents. Immiscible with polar solvents.
form 
Liquid
Specific Gravity
1.653
color 
Colorless to Almost colorless
Water Solubility 
REACTS
Sensitive 
Hygroscopic
BRN 
856036
Stability:
Moisture Sensitive
InChIKey
UFFSXJKVKBQEHC-UHFFFAOYSA-N
CAS DataBase Reference
336-59-4(CAS DataBase Reference)
NIST Chemistry Reference
Heptafluorobutyric anhydride(336-59-4)
EPA Substance Registry System
Heptafluorobutyric anhydride (336-59-4)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3265 8/PG 2
WGK Germany 
3
F 
10-21
Hazard Note 
Corrosive/Hygroscopic
TSCA 
T
HazardClass 
8
PackingGroup 
III
HS Code 
29159080
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
394912
Product name
Heptafluorobutyric anhydride
Purity
for GC derivatization, ≥99.0%
Packaging
5ml
Price
$169
Updated
2024/03/01
TCI Chemical
Product number
H0337
Product name
Heptafluorobutyric Anhydride
Purity
>95.0%(T)
Packaging
10g
Price
$50
Updated
2024/03/01
Alfa Aesar
Product number
A10744
Product name
Heptafluorobutyric anhydride, 98%
Packaging
5g
Price
$49.4
Updated
2024/03/01
Alfa Aesar
Product number
A10744
Product name
Heptafluorobutyric anhydride, 98%
Packaging
25g
Price
$152
Updated
2024/03/01
Sigma-Aldrich
Product number
H1006
Product name
Heptafluorobutyric anhydride
Purity
≥98%
Packaging
5ml
Price
$64.6
Updated
2024/03/01
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Heptafluorobutyric anhydride Chemical Properties,Usage,Production

Chemical Properties

clear colorless liquid

Uses

Heptafluorobutyric anhydride (HFAA) is frequently used as an acylating agent for the derivatization of primary and secondary amines (Walle and Ehrsson, 1971). Commercially available Heptafluorobutyric anhydride may afford low yields of the derivative due to the presence of Heptafluorobutyric acid (Moodie et al., 1985). This contaminant may be removed by ditillation over phosphorus pentoxide (Walle and Ehrsson, 1970).
HFAA is used to increase volatility of an analyte, and to introduce fluorine atoms for better detection limits in gas chromatography applications.
suzuki reaction

Uses

Heptafluorobutyric anhydride is used as a derivatization reagent for gas chromatography - mass mass spectrometry analysis of the stereoisomer content of synthetic peptides. It is a GC derivatizing agent used to prepare volatile derivatives of amino acids and other biologically active compounds.

Uses

As a GC derivatizing agent, Heptafluorobutyric anhydride is used to prepare volatile derivatives of amino acids and other biologically active compounds.

Definition

ChEBI: An acyclic carboxylic anhydride that is perfluorinated butyric anhydride. It is used as a derivatising reagent for gas chromatographic analyses.

General Description

Heptafluorobutyric anhydride is a perfluoroacylated acylation reagent, that forms stable, volatile derivatives with alcohols, amines, and phenols. It is majorly used to prepare electron-capturing derivatives for GC/electron capture detection. It is generally used with an acid scavenger, to help drive the reaction to completion and to prevent column damage from acidic by-products of the derivatization reaction. It is also used for the frequent testing of drugs of abuse such as, amphetamines and phencyclidine by GC-MS technique.

Heptafluorobutyric anhydride Preparation Products And Raw materials

Raw materials

Heptafluorobutyric acid Phosphorus pentoxide

Preparation Products

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Heptafluorobutyric anhydride Suppliers

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View Lastest Price from Heptafluorobutyric anhydride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Heptafluorobutyric anhydride 336-59-4
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-21
Hebei Weibang Biotechnology Co., Ltd
Product
Heptafluorobutyric anhydride 336-59-4
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-15
Hebei Mojin Biotechnology Co.,Ltd
Product
Heptafluorobutyric anhydride 336-59-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000KG/month
Release date
2024-08-28

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