Isatoic Anhydride
Synthesis- Product Name
- Isatoic Anhydride
- CAS No.
- 118-48-9
- Chemical Name
- Isatoic Anhydride
- Synonyms
- 1H-BENZO[D][1,3]OXAZINE-2,4-DIONE;Isatoic;2-(carboxyamino)-benzoicacicyclicanhydride;BENZOXAZINEDIONE;4H-3,1-Benzoxazine-2,4(1H)-dione;1,2-Dihydro-3,1-benzoxazine-2,4-dione;4H-3;Isatoic Ac;4(1H)-dione;1-Benzoxazine-2
- CBNumber
- CB9238051
- Molecular Formula
- C8H5NO3
- Formula Weight
- 163.13
- MOL File
- 118-48-9.mol
Isatoic Anhydride Property
- Melting point:
- 233 °C (dec.) (lit.)
- Boiling point:
- 290.19°C (rough estimate)
- Density
- 1,52 g/cm3
- vapor density
- 5.6 (vs air)
- refractive index
- 1.5510 (estimate)
- Flash point:
- 308 °C
- storage temp.
- Store below +30°C.
- solubility
- 0.3g/l
- form
- Powder
- pka
- 11.06±0.20(Predicted)
- color
- Beige to brown
- Water Solubility
- decomposes
- Sensitive
- Moisture Sensitive
- BRN
- 136786
- LogP
- 0.978 (est)
- CAS DataBase Reference
- 118-48-9(CAS DataBase Reference)
- NIST Chemistry Reference
- Isatoic anhydride(118-48-9)
- EPA Substance Registry System
- 2H-3,1-Benzoxazine-2,4(1H)-dione (118-48-9)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36-43
- Safety Statements
- 24-26-37
- WGK Germany
- 1
- RTECS
- DM3100000
- F
- 3
- Autoignition Temperature
- >600 °C
- TSCA
- Yes
- HS Code
- 29349990
- Hazardous Substances Data
- 118-48-9(Hazardous Substances Data)
- Toxicity
- LD50 orally in Rabbit: > 6400 mg/kg LD50 dermal Rabbit > 2000 mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I12808
- Product name
- Isatoic anhydride
- Purity
- 96%
- Packaging
- 100g
- Price
- $42.8
- Updated
- 2024/03/01
- Product number
- I12808
- Product name
- Isatoic anhydride
- Purity
- 96%
- Packaging
- 500g
- Price
- $149
- Updated
- 2024/03/01
- Product number
- 8.04784
- Product name
- Isatoic anhydride
- Purity
- for synthesis
- Packaging
- 100g
- Price
- $73.2
- Updated
- 2024/03/01
- Product number
- 8.04784
- Product name
- Isatoic anhydride
- Purity
- for synthesis
- Packaging
- 500g
- Price
- $461
- Updated
- 2023/01/07
- Product number
- I0081
- Product name
- Isatoic Anhydride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $60
- Updated
- 2024/03/01
Isatoic Anhydride Chemical Properties,Usage,Production
Synthesis
Isatoic Anhydride is synthesized from indole (9a) by stirring in a 4:1 mixture of DMF/H2O for 16 h at room temperature.
1 H NMR (DMSO-d6): δ11.73 (s, br., 1H), 7.92 (d, J = 7.8 Hz, 1H), 7.74 (t, J = 7.8 Hz, 1H), 7.26 (t, J = 7.8 Hz, 1H), 7.16 (d, J = 7.8 Hz, 1H).
Chemical Properties
BEIGE TO BROWN POWDER
Uses
Isatoic anhydride is a potent inactivator of α-chymotrypsin and inactivates stoichiometrically. Isatoic Anhydride is an important compound in the preparation of serine protease inhibitors.
Definition
A bicyclic molecule composed of a benzene ring attached at the oand mpositions to a heterocyclic ring. It forms useful anthranilic acid derivatives by reaction with hydrogen.
Preparation
Phosphorus tribromide (0.035 mol) was added to a solution of N-carbethoxy- or N-carbobenzoxy-anthranilic acid (0.1 mol;prepared by coupling anthranilic acid with the corresponding carbalkoxy chloride in the usual way) in anhydrous diethyl ether (100 mL). After 24 h at room temperature, isatoic anhydride had separated as a microcrystalline product. It was collected by filtration, washed with dry diethyl ether, and recrystallized from ethanol. Yield ca. 90%.
Flammability and Explosibility
Non flammable
Purification Methods
Recrystallise it from EtOH or 95% EtOH (30mL/g) or dioxane (10mL/g) and dry it in a vacuum. [Wagner & Fegley Org Synth Coll Vol III 488 1955, Ben-Ishai & Katchalski J Am Chem Soc 74 3688 1952, UV: Zentmyer & Wagner J Org Chem 14 967 1949, Beilstein 27 II 299, 27III/IV 3330.]
Isatoic Anhydride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Isatoic Anhydride manufacturers
- Product
- Isatoic Anhydride 118-48-9
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-05-27
- Product
- Isatoic Anhydride 118-48-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 20MT
- Release date
- 2024-08-30
- Product
- Isatoic Anhydride 118-48-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- >98%
- Supply Ability
- As your request
- Release date
- 2024-12-16