N-methylisatoic anhydride

Description Source Background

Product Name: N-methylisatoic anhydride
CAS No.: 10328-92-4
Chemical Name: N-methylisatoic anhydride
Synonyms: MIA;NSC439;NSC 439;NSC-439;AKOS 226;AI300638;NSC 76087;MIA human;4-dithiin;AI3 00638
CBNumber: CB3126220
Molecular Formula: C9H7NO3
Formula Weight: 177.16
MOL File: 10328-92-4.mol

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N-methylisatoic anhydride Property

Melting point:: 165 °C (dec.)(lit.)
Boiling point:: 309.06°C (rough estimate)
Density: 1.3312 (rough estimate)
vapor density: 6.1 (vs air)
refractive index: 1.5200 (estimate)
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in DMSO
form: Solid
pka: -2.24±0.20(Predicted)
color: White to yellow
Sensitive: Moisture Sensitive
InChI: InChI=1S/C9H7NO3/c1-10-7-5-3-2-4-6(7)8(11)13-9(10)12/h2-5H,1H3
InChIKey: KJMRWDHBVCNLTQ-UHFFFAOYSA-N
SMILES: N1(C)C2=CC=CC=C2C(=O)OC1=O
CAS DataBase Reference: 10328-92-4(CAS DataBase Reference)
EPA Substance Registry System: 2H-3,1-Benzoxazine-2,4(1H)-dione, 1-methyl- (10328-92-4)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
RTECS: DM3140000
TSCA: Yes
HS Code: 2934.99.4400

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 129887
Product name: N-Methylisatoic anhydride
Purity: technical, 90%
Packaging: 100g
Price: $92.4
Updated: 2025/07/31

TCI Chemical

Product number: M0743
Product name: N-Methylisatoic Anhydride
Packaging: 5G
Price: $102
Updated: 2025/07/31

TCI Chemical

Product number: M0743
Product name: N-Methylisatoic Anhydride
Purity: >98.0%(GC)
Packaging: 25g
Price: $400
Updated: 2025/07/31

TRC

Product number: M293158
Product name: 1-Methyl-1H-benzo[d][1,3]oxazine-2,4-dione
Packaging: 500mg
Price: $55
Updated: 2021/12/16

AK Scientific

Product number: 0785AA
Product name: N-Methylisatoic Anhydride
Packaging: 25g
Price: $169
Updated: 2021/12/16

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N-methylisatoic anhydride Chemical Properties,Usage,Production

Chemical Properties

brownish chunks

Uses

N-Methylisatoic anhydride is a 2'-OH selective acylation agent of RNAs, and is widely used for resolving secondary RNA structures using the SHAPE (Selective 2'-Hydroxyl Acylation Analyzed by Primer Extension) technology.

Definition

ChEBI: N-methylisatoic anhydride is a 3,1-benzoxazin-1,4-dione having an N-methyl substituent.

Application

N-Methylisatoic anhydride was first condensed with ethanolamine to give N-(2-hydroxyethyl)-2-methylaminobenzamide. Cyclization of the latter with ethyl pyruvate gave quinazoline derivatives which, upon hydrolysis and dehydrative cyclization with l-methyl-2-chloropyridinium iodide, afforded the l,4-oxazines[3,4-]quinazoline.

Description

Melanoma Inhibitory Activity Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain consisting of 108 amino having a total molecular mass of 12237 Dalton.
The MIA is purified by proprietary chromatographic techniques.

Source

Escherichia Coli

Background

The Melanoma Inhibitory protein (MIA) was identified as an inhibitor of in vitro growth of malignant melanoma cells. The protein contains a SH3 domain.
MIA acts as a potent tumor cell growth inhibitor for malignant melanoma cells and some other neuroectodermal tumors, including gliomas, in an autocrine fashion. In a study of human melanoma cell lines with different metastatic capacity MIA mRNA expression appeared to be inversely correlated with pigmentation. MIA has been shown to represent a very sensitive and specific serum marker for systemic malignant melanoma that might be useful for staging of primary melanomas, detection of progression from localized to metastatic disease during follow-up, and monitoring therapy of advanced melanomas.

N-methylisatoic anhydride Preparation Products And Raw materials

Raw materials

Preparation Products

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N-methylisatoic anhydride Suppliers

Americas 1 Belgium 1 Canada 1 China 111 Europe 1 France 1 Germany 5 India 3 Japan 3 Switzerland 2 United Kingdom 4 United States 31 Global 164

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Syntechem Co.,Ltd

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View Lastest Price from N-methylisatoic anhydride manufacturers

Shanghai Rlavie Technology Co ltd

Product: N-Methylisatoic anhydride 10328-92-4
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%minHPLC
Supply Ability: 500kgs/month
Release date: 2021-11-14

Career Henan Chemical Co

Product: N-METHYLISATOIC ANHYDRIDE 10328-92-4
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20kg
Release date: 2018-07-25

Career Henan Chemical Co

Product: N-METHYLISATOIC ANHYDRIDE 10328-92-4
Price: US $20.00/KG
Min. Order: 1KG
Purity: 995
Supply Ability: 20kg
Release date: 2018-07-30

10328-92-4, N-methylisatoic anhydrideRelated Search:

5-Chloro-N-methylisatoic anhydride N-methylisatoic anhydride Ethyl 4-dimethylaminobenzoate Isatoic Anhydride 1-ISOPROPYL-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE N-BENZYLISATOIC ANHYDRIDE 5-CHLORO-1-METHYL-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE 3-METHOXY-N-METHYLISATOIC ANHYDRIDE N-ALLYLISATOIC ANHYDRIDE 6-Methylisatoic anhydride 5-METHYLISATOIC ANHYDRIDE 7-FLUORO-2-METHYLISATOIC ANHYDRIDE AMILORIDE, 5-(N-METHYL-N-ISOBUTYL) (MIA) >97% EXTREMELY POTE,MIA 6-CHLORO-N-METHYLISATOIC ANHYDRIDE N-METHYLISATOIC ANHYDRIDE POLYSTYRENE (100-200 MESH, 3 MMOL/G) HUMAN MIA KG POA 5-METHYLISATOIC ANHYDRIDE MIA protein

N-methyl isotoic anhydride

Isatoic anhydride, N-Methyl-

N-Methylisatioc anhydride

1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione

1-Methyl-1,2-dihydro-4H-3,1-benzoxazine-2,4-dione

1-Methyl-1H-3,1-benzoxazine-2,4-dione

1-Methyl-4H-3,1-benzoxazine-2(1H),4-dione

N-Methylisatoic anhydride,90%,tech.

N-Methylisatoic anhydride (NMIA)

1-methyl-3,1-benzoxazine-2,4-dione

<i>N</i>-Methylisatoic Anhydride

MIA

N-METHYLISATOIC ANHYDRIDE

TIMTEC-BB SBB000196

1-Methyl-2H-3,1-benzoxazine-2,4(1H)-dione

2H-3,1-Benzoxazine-2,4(1H)-dione, 1-methyl-

4(1h)-dione,1-methyl-2h-1-benzoxazine-2

N-Methyl ia

n-methylia

N-Methyl-N-carboxyanthranilic anhydride

N-METHYLISATOIC ANHYDRIDE, TECH., 90%

N-Methylisatoicanhydride,tech.,90%

AKOS 226

1-Methyl-4H-3,1-benzoxazine-2,4(1H)dione

N-Methylisatoic acid anhydride

NSC 76087

N-Methylisatoic anhydride technical, 90%

Melanoma-derived growth regulatory protein precursor

MIA human

N-MethylisatoicAnhydride&gt

10-Dithiaanthracene

4-dithiin

AI3 00638

AI300638

AI3-00638

dibenzo-1

NSC 439

NSC439

NSC-439

N-Methylisatoic anhydride, 10 mM in DMSO

10328-92-4

10328-92-7

Monomers

Polymer Science

pharmacetical

Anhydride Monomers