N-methylisatoic anhydride
Description Source Background- Product Name
- N-methylisatoic anhydride
- CAS No.
- 10328-92-4
- Chemical Name
- N-methylisatoic anhydride
- Synonyms
- MIA;NSC439;NSC 439;NSC-439;AKOS 226;AI300638;NSC 76087;MIA human;4-dithiin;AI3 00638
- CBNumber
- CB3126220
- Molecular Formula
- C9H7NO3
- Formula Weight
- 177.16
- MOL File
- 10328-92-4.mol
N-methylisatoic anhydride Property
- Melting point:
- 165 °C (dec.)(lit.)
- Boiling point:
- 309.06°C (rough estimate)
- Density
- 1.3312 (rough estimate)
- vapor density
- 6.1 (vs air)
- refractive index
- 1.5200 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- -2.24±0.20(Predicted)
- color
- White to yellow
- Sensitive
- Moisture Sensitive
- InChI
- InChI=1S/C9H7NO3/c1-10-7-5-3-2-4-6(7)8(11)13-9(10)12/h2-5H,1H3
- InChIKey
- KJMRWDHBVCNLTQ-UHFFFAOYSA-N
- SMILES
- N1(C)C2=CC=CC=C2C(=O)OC1=O
- CAS DataBase Reference
- 10328-92-4(CAS DataBase Reference)
- EPA Substance Registry System
- 2H-3,1-Benzoxazine-2,4(1H)-dione, 1-methyl- (10328-92-4)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 129887
- Product name
- N-Methylisatoic anhydride
- Purity
- technical, 90%
- Packaging
- 100g
- Price
- $92.4
- Updated
- 2025/07/31
- Product number
- M0743
- Product name
- N-Methylisatoic Anhydride
- Packaging
- 5G
- Price
- $102
- Updated
- 2025/07/31
- Product number
- M0743
- Product name
- N-Methylisatoic Anhydride
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $400
- Updated
- 2025/07/31
- Product number
- M293158
- Product name
- 1-Methyl-1H-benzo[d][1,3]oxazine-2,4-dione
- Packaging
- 500mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 0785AA
- Product name
- N-Methylisatoic Anhydride
- Packaging
- 25g
- Price
- $169
- Updated
- 2021/12/16
N-methylisatoic anhydride Chemical Properties,Usage,Production
Chemical Properties
brownish chunks
Uses
N-Methylisatoic anhydride is a 2'-OH selective acylation agent of RNAs, and is widely used for resolving secondary RNA structures using the SHAPE (Selective 2'-Hydroxyl Acylation Analyzed by Primer Extension) technology.
Definition
ChEBI: N-methylisatoic anhydride is a 3,1-benzoxazin-1,4-dione having an N-methyl substituent.
Application
N-Methylisatoic anhydride was first condensed with ethanolamine to give N-(2-hydroxyethyl)-2-methylaminobenzamide. Cyclization of the latter with ethyl pyruvate gave quinazoline derivatives which, upon hydrolysis and dehydrative cyclization with l-methyl-2-chloropyridinium iodide, afforded the l,4-oxazines[3,4-]quinazoline.
Description
Melanoma Inhibitory Activity Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain consisting of 108 amino having a total molecular mass of 12237 Dalton.
The MIA is purified by proprietary chromatographic techniques.
Source
Escherichia Coli
Background
The Melanoma Inhibitory protein (MIA) was identified as an inhibitor of in vitro growth of malignant melanoma cells. The protein contains a SH3 domain.
MIA acts as a potent tumor cell growth inhibitor for malignant melanoma cells and some other neuroectodermal tumors, including gliomas, in an autocrine fashion. In a study of human melanoma cell lines with different metastatic capacity MIA mRNA expression appeared to be inversely correlated with pigmentation. MIA has been shown to represent a very sensitive and specific serum marker for systemic malignant melanoma that might be useful for staging of primary melanomas, detection of progression from localized to metastatic disease during follow-up, and monitoring therapy of advanced melanomas.
N-methylisatoic anhydride Preparation Products And Raw materials
Raw materials
Preparation Products
N-methylisatoic anhydride Suppliers
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View Lastest Price from N-methylisatoic anhydride manufacturers
- Product
- N-Methylisatoic anhydride 10328-92-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%minHPLC
- Supply Ability
- 500kgs/month
- Release date
- 2021-11-14
- Product
- N-METHYLISATOIC ANHYDRIDE 10328-92-4
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2018-07-25
- Product
- N-METHYLISATOIC ANHYDRIDE 10328-92-4
- Price
- US $20.00/KG
- Min. Order
- 1KG
- Purity
- 995
- Supply Ability
- 20kg
- Release date
- 2018-07-30