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5-Fluoroisatonic anhydride

Product Name
5-Fluoroisatonic anhydride
CAS No.
321-69-7
Chemical Name
5-Fluoroisatonic anhydride
Synonyms
6-fluoro-2H-benzo[d][1,3]oxazine-2,4(1H)-dione;5-FLUOROISATOIC ANHYDRIDE;NSC 149815;Flumazenil Impurity 15;6-FLUORO ISATIN ANHYDRIDE;5-FLUOROISATONIC ANHYDRIDE;6-fluoro-1H-3,1-benzoxazine-2,4-dione;6-Fluorobenzo[d][1,3]oxazine-2,4-dione;6-fluoro-1H-3,1-benzoxazine-2,4-quinone;6-FLUORO-2H-3,1-BENZOXAZINE-2,4(1H)-DIONE
CBNumber
CB5379596
Molecular Formula
C8H4FNO3
Formula Weight
181.12
MOL File
321-69-7.mol
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5-Fluoroisatonic anhydride Property

Melting point:
259-262°C
Density 
1.502±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
soluble in DMSO
pka
9.61±0.20(Predicted)
form 
powder
color 
Off-white to pale yellow
InChI
InChI=1S/C8H4FNO3/c9-4-1-2-6-5(3-4)7(11)13-8(12)10-6/h1-3H,(H,10,12)
InChIKey
UBKGOWGNYKVYEF-UHFFFAOYSA-N
SMILES
N1C2=CC=C(F)C=C2C(=O)OC1=O
CAS DataBase Reference
321-69-7(CAS DataBase Reference)
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36
HazardClass 
IRRITANT
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC
Product number
F592025
Product name
5-FluoroisatoicAnhydride
Packaging
2g
Price
$210
Updated
2021/12/16
AK Scientific
Product number
Y7452
Product name
6-Fluoroisatoicanhydride
Packaging
25g
Price
$211
Updated
2021/12/16
ChemScene
Product number
CS-W005876
Product name
5-Fluoroisatoicanhydride
Purity
≥98.0%
Packaging
25g
Price
$318
Updated
2021/12/16
Matrix Scientific
Product number
057951
Product name
6-Fluoro-1H-benzo[d][1,3]oxazine-2,4-dione
Purity
99%
Packaging
100g
Price
$474
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0025236
Product name
6-FLUORO ISATIN ANHYDRIDE
Purity
95.00%
Packaging
1G
Price
$626.01
Updated
2021/12/16
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5-Fluoroisatonic anhydride Chemical Properties,Usage,Production

Chemical Properties

Dark yellow Solid

Uses

5-Fluoroisatoic Anhydride is a versatile pharmaceutical intermediate used in the preparation of insulin secretagogues, HCV polymerase inhibitors, anxiolytic agents and other bioactive compounds.

Preparation

5-Fluoroisatonic anhydride is prepared from 5-fluoro indole (9d) by stirring in a 4:1 mixture of DMF/H2O for 16 h at room temperature.
1 H NMR (DMSO-d6): δ11.19 (s, br., 1H), 7.36 (dd, J = 8.4, 2.6 Hz, 1H), 6.87 (dt, J = 8.4, 2.2 Hz, 1H), 6.74 (dd, J = 9.3, 2.2 Hz, 1H).

Synthesis

443-69-6

321-69-7

Preparation of compound 1: Synthesis of 5-fluoroisocyanic anhydride. In a 250 mL three-necked flask assembled with a magnetic stir bar and condenser, acetic anhydride (90.0 mL), 5-fluoroindigo (20.62 g, 0.125 mol, 1.00 equiv.) and acetic acid (90 mL) were added sequentially. The reaction system was placed in a water bath and heated to 85 °C. Subsequently, chromium(VI) oxide (20.36 g, 0.204 mol, 1.63 eq.) was added in batches (~0.5 g per batch) to the red solution over 40 minutes. After addition, the reaction mixture was continued to be stirred for 15 minutes and subsequently cooled to 10 °C in an ice bath. The resulting solid product was separated by filtration and washed with 400 mL of water to remove most of the green impurities. The resulting solid was dissolved in 300 mL of a 2:1 (v/v) acetic acid/water mixture, filtered again, and dried overnight in a vacuum oven at 50 °C to afford 5-fluoroisocyanic anhydride as a bright yellow solid (14.45 g, 64% yield).

References

[1] Catalysis Science and Technology, 2015, vol. 5, # 10, p. 4830 - 4838
[2] Angewandte Chemie, 1980, vol. 92, # 3, p. 196 - 197
[3] Patent: US5863944, 1999, A
[4] Journal of the Chemical Society, 1957, p. 2916,2917
[5] Journal of medicinal chemistry, 1971, vol. 14, # 12, p. 1233 - 1235

5-Fluoroisatonic anhydride Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Fluoroisatonic anhydride Suppliers

Canada 1 China 136 Germany 2 India 2 Ukraine 1 United Kingdom 6 United States 17 Global 165
Hangzhou Aolishen Chemical Co., Ltd.
Tel
571-81727727 15267468089
Email
Frank.luo@aolisenchemical.com
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China
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J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
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market03@meryer.com
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China
ProdList
40228
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ChemFuture PharmaTech (Jiangsu) Ltd
Tel
5108538618
Fax
86 510 85386988-8017
Email
suger.wang@chemfuture.com
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China
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Energy Chemical
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021-021-58432009 400-005-6266
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021-58436166
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sales8178@energy-chemical.com
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China
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Wuhan Chemwish Technology Co., Ltd
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86-027-67849912
Fax
86-027-87531808
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sales@chemwish.com
Country
China
ProdList
35896
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Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Fax
+86-21-54096319
Email
sales@sinch.com.cn
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China
ProdList
11598
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Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
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China
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Shanghai Harvest Chemical Industrial Co., Ltd.
Tel
021-31038972,31038973 17321035817
Fax
+86-21-51385350
Email
sales@harvest-chem.com
Country
China
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2816
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View Lastest Price from 5-Fluoroisatonic anhydride manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd
Product
5-Fluoroisatoic anhydride 321-69-7
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
Customise
Release date
2025-08-20
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
5-Fluoroisatonic anhydride 321-69-7
Price
US $1.60-6.60/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-19
Career Henan Chemical Co
Product
5-Fluoroisatonic anhydride 321-69-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
G/KG/T
Release date
2019-12-24

321-69-7, 5-Fluoroisatonic anhydrideRelated Search:

Glutaric anhydride Phthalic anhydride Trifluoromethanesulfonic anhydride Succinic anhydride 5-Fluoroisatin Erythromycin Estolate CIS-BUTENEDIOIC ANHYDRIDE Chromium(VI) oxide Isatoic Anhydride Di-tert-butyl dicarbonate Indirubin Acetic anhydride 6-Fluoroisatoic anhydride 5-FLUOROISATOIC ANHYDRIDE 7-FLUORO-1-H-BENZO[D][1,3]OXAZINE-2,4-DIONE 4-FLUOROISATOIC ANHYDRIDE 3-FLUOROISATOIC ANHYDRIDE 5-Fluoroisatonic anhydride

  • 6-FLUORO-2H-3,1-BENZOXAZINE-2,4(1H)-DIONE
  • 6-fluoro-1H-benzo[d][1,3]oxazine-2,4-dione
  • 6-fluoro-1H-3,1-benzoxazine-2,4-dione
  • 6-fluoro-1H-3,1-benzoxazine-2,4-quinone
  • 6-FLUORO ISATIN ANHYDRIDE
  • 5-FLUOROISATOIC ANHYDRIDE
  • 5-FLUOROISATONIC ANHYDRIDE
  • 6-Fluorobenzo[d][1,3]oxazine-2,4-dione
  • NSC 149815
  • 6-fluoro-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione
  • 6-Fluoro-2H-3,1-benzoxazine-2,4(1H)-dione, 6-Fluoro-1H-benzo[d][1,3]oxazine-2,4-dione
  • 2H-3,1-Benzoxazine-2,4(1H)-dione, 6-fluoro-
  • 6-fluoro-2H-benzo[d][1,3]oxazine-2,4(1H)-dione
  • Flumazenil Impurity 15
  • 321-69-7
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  • Aromatics
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