5-Fluoroisatin
- Product Name
- 5-Fluoroisatin
- CAS No.
- 443-69-6
- Chemical Name
- 5-Fluoroisatin
- Synonyms
- 5-FLUOROINDOLINE-2,3-DIONE;Fluoroisatin;5-FLUORO-1H-INDOLE-2,3-DIONE;NSC 39161;uoroisatin;5-Fluorosatin;5-FLUOROISATIN;5-FLUOROISATINE;5- fluoroindigo;5-Flluoroisatin
- CBNumber
- CB4206497
- Molecular Formula
- C8H4FNO2
- Formula Weight
- 165.12
- MOL File
- 443-69-6.mol
5-Fluoroisatin Property
- Melting point:
- 224-227 °C (lit.)
- Density
- 1.477±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform, DMSO, Methanol
- pka
- 8.51±0.20(Predicted)
- form
- Powder
- color
- Red
- BRN
- 131241
- InChI
- InChI=1S/C8H4FNO2/c9-4-1-2-6-5(3-4)7(11)8(12)10-6/h1-3H,(H,10,11,12)
- InChIKey
- GKODDAXOSGGARJ-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(F)C=C2)C(=O)C1=O
- CAS DataBase Reference
- 443-69-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-37/39-36
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29337900
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 366978
- Product name
- 5-Fluoroisatin
- Purity
- 98%
- Packaging
- 5g
- Price
- $54.8
- Updated
- 2025/07/31
- Product number
- F0589
- Product name
- 5-Fluoroisatin
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $39
- Updated
- 2025/07/31
- Product number
- F0589
- Product name
- 5-Fluoroisatin
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $112
- Updated
- 2025/07/31
- Product number
- F592000
- Product name
- 5-FluoroIsatin
- Packaging
- 100g
- Price
- $465
- Updated
- 2021/12/16
- Product number
- 008155
- Product name
- 5-Fluoroisatin
- Purity
- 98%
- Packaging
- 1g
- Price
- $9
- Updated
- 2021/12/16
5-Fluoroisatin Chemical Properties,Usage,Production
Chemical Properties
red Crystalline Powder
Uses
Reactant for preparation of:
- Spiro[indole-thiazolidinones] as biologically relevan synthesis scaffolds
- Potential antimycobacterial agents
- Inhibitors of c-Met kinase
- Inhibitors of TAK1 kinase
- Herpes simplex virus inhibitors
- IKKβ inhibitors
- Inhibitors of vitiligo disease
- Potential drug candidates with anti-HIV activity and anti-tubercular activity
Uses
It showed antibacterial and antifungal activities.
Definition
ChEBI: 5-Fluoroisatin is a member of indoles. It has a role as an anticoronaviral agent.
General Description
5-Fluoroisatin has been reported as the precursor of the Sunitinib (Sutent) drug. 5-Fluoroisatin has been approved by the Food and Drugs Administration (FDA) in 2006 for the treatment of renal cell carcinoma (RCC) and gastrointestinal stromal tumor (GIST).
Synthesis
351-09-7
443-69-6
Concentrated sulfuric acid (24.0 mL) was added to a dry 150 mL three-necked flask and heated to 50 °C. The intermediate synthesized above (2a-2d, 30.0 mmol) was slowly added and the color of the solution gradually deepened to black as the intermediate was added. After the addition was completed, the reaction temperature was raised to 80 °C and the reaction was maintained for 20 min. Subsequently, crushed ice (100 g) was slowly added to the reaction system, at which time the ice-water mixture showed a reddish brown color. After standing, the reaction mixture was filtered and washed with deionized water until neutral. The resulting solid was dissolved in 10.0% NaOH solution (90 mL), the pH was adjusted to 4 with concentrated hydrochloric acid and filtered. The filtrate was continued to adjust the pH to 2 with concentrated hydrochloric acid, at which time a large amount of brick red solid precipitated. The solid was collected by filtration and dried to give the reddish brown target products 3a-3d. (Elution conditions: petroleum ether: ethyl acetate, v/v = 1:2, Rf = 0.4-0.6).
References
[1] Patent: CN107033064, 2017, A. Location in patent: Paragraph 0050; 0051; 0052; 0053
[2] Journal of the Brazilian Chemical Society, 2019, vol. 30, # 1, p. 198 - 209
[3] Synthetic Communications, 1999, vol. 29, # 20, p. 3627 - 3633
[4] Medicinal Chemistry, 2016, vol. 12, # 5, p. 489 - 498
[5] Journal of Heterocyclic Chemistry, 2018, vol. 55, # 12, p. 2919 - 2928
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View Lastest Price from 5-Fluoroisatin manufacturers
- Product
- 5-Fluoroisatin 443-69-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-08-19
- Product
- Flumazenil Impurity 8 443-69-6
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 95%+
- Supply Ability
- 100000000000
- Release date
- 2025-01-14
- Product
- 5-Fluoroisatin 443-69-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08