4-Chloro-isatoic anhydride

Product Name: 4-Chloro-isatoic anhydride
CAS No.: 40928-13-0
Chemical Name: 4-Chloro-isatoic anhydride
Synonyms: AURORA KA-6696;6-CHLOROISATOIC ANHYDRIDE;7-CHLOROISATOIC ANHYDRIDE;4-CHLORO-ISATOIC ANHYDRIDE;4-CHLOROISATONIC ANHYDRIDE;4-Chloroisatoic Anhydride >7-chloro-1H-3,1-benzoxazine-2,4-dione;7-chloro-1H-3,1-benzoxazine-2,4-quinone;7-chloro-2H-3,1-benzoxazine-2,4(1H)-dione;7-CHLORO-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE
CBNumber: CB3190971
Molecular Formula: C8H4ClNO3
Formula Weight: 197.58
MOL File: 40928-13-0.mol

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4-Chloro-isatoic anhydride Property

Melting point:: 255-259 °C
Density: 1.540±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: soluble in Dimethylformamide
form: powder to crystal
pka: 9.95±0.20(Predicted)
color: White to Light yellow
CAS DataBase Reference: 40928-13-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36/37
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 691720
Product name: 4-Chloroisatoic anhydride
Purity: 97%
Packaging: 1g
Price: $42.1
Updated: 2023/06/20

TCI Chemical

Product number: C2790
Product name: 4-Chloroisatoic Anhydride
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $42
Updated: 2025/07/31

TCI Chemical

Product number: C2790
Product name: 4-Chloroisatoic Anhydride
Packaging: 5G
Price: $182
Updated: 2025/07/31

TRC

Product number: C427658
Product name: 4-Chloroisatoic Anhydride
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: C427658
Product name: 4-Chloroisatoic Anhydride
Packaging: 500mg
Price: $65
Updated: 2021/12/16

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4-Chloro-isatoic anhydride Chemical Properties,Usage,Production

Chemical Properties

White solid

Synthesis Reference(s)

The Journal of Organic Chemistry, 26, p. 613, 1961 DOI: 10.1021/jo01061a618

Synthesis

32315-10-9

89-77-0

40928-13-0

General procedure for the synthesis of 7-chloro-1H-benzo[d][1,3]oxazine-2,4-dione from triphosgene and 2-amino-4-chlorobenzoic acid: 1. Preparation of Intermediate G: To a stirred solution of 2-amino-4-chlorobenzoic acid (10 g, 0.058 mol) in acetonitrile (60 mL), a solution of pyridine (9.4 mL, 0.117 mol, 2 eq.) and triphosgene (17.3 g, 0.058 mol, 1 eq.) in dichloromethane (85 mL, 0.7 M) was slowly added. 2. Treatment of the reaction mixture: the resulting orange reaction solution was heated at 50 °C for 2 h and subsequently cooled to room temperature. 3. Separation and purification: the reaction solution was diluted with water (50 mL) to separate the organic and aqueous layers. The aqueous layer was extracted with dichloromethane (3 x 50 mL) and the combined organic layers were washed once with brine (50 mL) and dried with anhydrous magnesium sulfate. 4. Purification of products: The reaction solution was heated at 50 °C for 2 h and subsequently cooled to room temperature. 4. Purification of product: The solvent was removed by distillation under reduced pressure to give a yellow solid. The solid was recrystallized from hexane to give 7-chloro-1H-benzo[d][1,3]oxazine-2,4-dione (9.1 g, 74% yield) as a yellow solid. 1H NMR (acetone-d6, 500 MHz): δ (ppm) 7.13-7.14 (1H, s), 7.28-7.30 (1H, d, J = 8.5 Hz), 7.90-7.92 (1H, d, J = 8.6 Hz), 11.84 (1H, bs).

References

[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 17, p. 6928 - 6937
[2] Journal of Medicinal Chemistry, 2006, vol. 49, # 7, p. 2311 - 2319
[3] Patent: US9126978, 2015, B2. Location in patent: Page/Page column 57; 58
[4] European Journal of Medicinal Chemistry, 1994, vol. 29, # 12, p. 925 - 940
[5] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 10, p. 2295 - 2299

4-Chloro-isatoic anhydride Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Chloro-isatoic anhydride Suppliers

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View Lastest Price from 4-Chloro-isatoic anhydride manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: 4-chloroisatoic anhydride 40928-13-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-08-20

Career Henan Chemical Co

Product: 4-Chloro-isatoic anhydride 40928-13-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-31

40928-13-0, 4-Chloro-isatoic anhydrideRelated Search:

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4-CHLORO-ISATOIC ANHYDRIDE

7-CHLOROISATOIC ANHYDRIDE

7-CHLORO-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE

6-CHLOROISATOIC ANHYDRIDE

4-CHLOROISATONIC ANHYDRIDE

AURORA KA-6696

7-Chloro-2H-3,1-benzoxazine-2,4(1H)-dione, 7-Chloroisatoic anhydride

7-chloro-2H-3,1-benzoxazine-2,4(1H)-dione

2H-3,1-Benzoxazine-2,4(1H)-dione, 7-chloro-

7-chloro-1H-3,1-benzoxazine-2,4-dione

7-chloro-1H-3,1-benzoxazine-2,4-quinone

7-chloro-2H-benzo[d][1,3]oxazine-2,4(1H)-dione

7-chloro-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione

4-Chloroisatoic Anhydride &gt

7-Chloro-1,2-dihydro-4H-3,1-benzoxazine-2,4-dione

40928-13-0

C8H4CINO3

Benzoxazines

Building Blocks

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks

Heterocyclic Compounds

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts