5-(3-METHOXY-PHENYL)-2H-PYRAZOL-3-YLAMINE
- Product Name
- 5-(3-METHOXY-PHENYL)-2H-PYRAZOL-3-YLAMINE
- CAS No.
- 96799-04-1
- Chemical Name
- 5-(3-METHOXY-PHENYL)-2H-PYRAZOL-3-YLAMINE
- Synonyms
- 3-Amino-5-(3-methoxyphenyl)-1H-pyrazole;1H-Pyrazol-3-amine, 5-(3-methoxyphenyl)-;3-(3-Methoxy-phenyl)-2H-pyrazol-3-ylamine;5-(3-METHOXY-PHENYL)-2H-PYRAZOL-3-YLAMINE;[5-(3-methoxyphenyl)-1H-pyrazol-3-yl]amine;3-(3-methoxyphenyl)-1H-pyrazol-5-amine 1HCl;JR-13696, 3-(3-Methoxyphenyl)-1H-pyrazol-5-amine, 96%;3-(3-methoxyphenyl)-1H-pyrazol-5-amine(SALTDATA: HCl)
- CBNumber
- CB5219256
- Molecular Formula
- C10H11N3O
- Formula Weight
- 189.21
- MOL File
- 96799-04-1.mol
5-(3-METHOXY-PHENYL)-2H-PYRAZOL-3-YLAMINE Property
- Boiling point:
- 456.7±35.0 °C(Predicted)
- Density
- 1.240±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 14.54±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M350200
- Product name
- 3-(3-Methoxyphenyl)-1H-pyrazol-5-amine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 075822
- Product name
- 5-(3-Methoxyphenyl)-2H-pyrazol-3-ylamine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $347
- Updated
- 2021/12/16
- Product number
- W9817
- Product name
- 5-(3-Methoxyphenyl)-2H-pyrazol-3-ylamine
- Packaging
- 5g
- Price
- $212
- Updated
- 2021/12/16
- Product number
- 075822
- Product name
- 5-(3-Methoxyphenyl)-2H-pyrazol-3-ylamine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $958
- Updated
- 2021/12/16
- Product number
- CHM0068738
- Product name
- 1H-PYRAZOL-3-AMINE, 5-(3-METHOXYPHENYL)-
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $958.65
- Updated
- 2021/12/16
5-(3-METHOXY-PHENYL)-2H-PYRAZOL-3-YLAMINE Chemical Properties,Usage,Production
Synthesis
21667-60-7
96799-04-1
b) Synthesis of 5-(3-methoxyphenyl)-2H-pyrazol-3-amine To a solution of 3-(3-methoxyphenyl)-3-oxopropanenitrile (8.96 mmol) in anhydrous ethanol (20 mL) was added hydrazine monohydrate (0.52 mL, 15 mmol), and the reaction mixture was heated and refluxed for 18 hours. After completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure to remove the solvent. The crude product was washed with ether and filtered to give 1.4 g of the title compound in 83% yield. Product Characterization: Molecular formula: C10H11N3O Theoretical mass-to-charge ratio (m/z): 189 Measured mass-to-charge ratio (m/z): [M + H+] = 190 Liquid chromatography retention time (LC Rt): 1.13 min (5 min method) 1H-NMR (400 MHz, MeOH-d4) δ: 3.82 (3H, s, OCH3); 5.93 (1H, s, CH); 6.86-6.88 (1H, m, ArH); 7.19-7.31 (3H, m, ArH).
References
[1] Patent: WO2008/87529, 2008, A1. Location in patent: Page/Page column 105
[2] Patent: WO2010/9290, 2010, A1. Location in patent: Page/Page column 136
[3] Patent: WO2007/98826, 2007, A2. Location in patent: Page/Page column 71
[4] Beilstein Journal of Organic Chemistry, 2018, vol. 14, p. 122 - 1228
[5] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 22, p. 7501 - 7511
5-(3-METHOXY-PHENYL)-2H-PYRAZOL-3-YLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
5-(3-METHOXY-PHENYL)-2H-PYRAZOL-3-YLAMINE Suppliers
- Tel
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