14,15-LEUKOTRIENE D4
- Product Name
- 14,15-LEUKOTRIENE D4
- CAS No.
- 75290-64-1
- Chemical Name
- 14,15-LEUKOTRIENE D4
- Synonyms
- Eoxin D4;14,15-LEUKOTRIENE D4;Glycine, S-[(1R,2E,4E,6Z,9Z)-13-carboxy-1-[(1S)-1-hydroxyhexyl]-2,4,6,9-tridecatetraen-1-yl]-L-cysteinyl-
- CBNumber
- CB5226768
- Molecular Formula
- C25H40N2O6S
- Formula Weight
- 496.66
- MOL File
- 75290-64-1.mol
14,15-LEUKOTRIENE D4 Property
- Boiling point:
- 786.4±60.0 °C(Predicted)
- Density
- 1.162±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): >100 μg/ml
- pka
- 3.03±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 10011361
- Product name
- 14,15-Leukotriene D4
- Purity
- ≥97%
- Packaging
- 25μg
- Price
- $127
- Updated
- 2024/03/01
- Product number
- 10011361
- Product name
- 14,15-Leukotriene D4
- Purity
- ≥97%
- Packaging
- 50μg
- Price
- $236
- Updated
- 2024/03/01
- Product number
- 10011361
- Product name
- 14,15-Leukotriene D4
- Purity
- ≥97%
- Packaging
- 100μg
- Price
- $447
- Updated
- 2024/03/01
- Product number
- E561500
- Product name
- EoxinD4
- Packaging
- 50g
- Price
- $195
- Updated
- 2021/12/16
14,15-LEUKOTRIENE D4 Chemical Properties,Usage,Production
Description
14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. 14,15-LTD4 is classified as an eoxin (EXD4), because it is formed mostly by eosinophils. However, mast cells and nasal polyps can synthesize 14,15-LTD4 as well. Little is known about the physiological actions of 14,15-LTD4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs. However, in an in vitro permeability assay, 14,15-LTD4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs, resulting in plasma leakage, a hallmark of inflammation.
Uses
Eoxin D4 is synthesized via the 15-lipoxygenase-1 pathway in human eosinophils. Eoxins are proinflammatory arachidonic acid metabolites produced by mast cells.
Definition
ChEBI: Eoxin D4 is a leukotriene that is the 14R-(S-cysteinylglycyl),15S-hydroxy derivative of (5Z,8Z,10E,12E)-icosa-7,9,11,14-tetraenoic acid. It has a role as a metabolite. It is a leukotriene and an eoxin. It is functionally related to a (5Z,8Z,10E,12E)-icosatetraenoic acid.
14,15-LEUKOTRIENE D4 Preparation Products And Raw materials
Raw materials
Preparation Products
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