GADOLINIUM CHLORIDE Property

Melting point:

609°C

Density 

4,52 g/cm³

storage temp. 

Hygroscopic, Room Temperature, under inert atmosphere

solubility 

Water

form 

powder

color 

White to off-white

Specific Gravity

4.52

Water Solubility 

Soluble in water.

Sensitive 

Hygroscopic

Merck 

14,4326

Stability:

hygroscopic

CAS DataBase Reference

10138-52-0(CAS DataBase Reference)

EPA Substance Registry System

Gadolinium chloride (GdCl3) (10138-52-0)

Safety

Hazard Codes 

Xi

Risk Statements 

38

Safety Statements 

36/37

WGK Germany 

3

RTECS 

ZC0230000

F 

10-21

TSCA 

Yes

HS Code 

28273985

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

GADOLINIUM CHLORIDE Chemical Properties,Usage,Production

Physical Properties

White monoclinic crystal; hygroscopic; density 4.52 g/cm3; melts at 609°C; soluble in water.

Preparation

GdCl3 is prepared by heating gadolinium(III) oxide with excess of ammonium chloride above 200°C:
Gd2O3 + 6NH4Cl→2GdCl3 + 6NH3 + 3H2O

Chemical Properties

Colorless crystals, soluble in water, purities up to 99.9%.

Uses

Gadolinium(III) Chloride is used as chelating agents, which is essential for biomedical applications. It is also employed in the synthesis and nuclear magnetic resonance (NMR) studies of paramagnetic GdPCTA-[12] and GdPCTA-[13] complexes. It plays an important role as contrast agent for magnetic resonance imaging and an macrophage inhibitor.

Uses

GadoliniuM chloride, anhydrous is a calcium-sensing receptor agonist and is known to work by inducing NLRP3 inflammasome activation in bone marrow-derived macrophages.
GdCl3 is used for preparing gadolinium metal.

Definition

ChEBI: Gadolinium trichloride is a gadolinium coordination entity. It has a role as a TRP channel blocker.

Biological Activity

gadolinium chloride is a casr agonist. the casr can activate the nlrp3 inflammasome by increasing intracellular ca2+ and decreasing cellular cyclic amp. thus, casr agonists may serve as a useful tool for exploring nlrp3 inflammasome associated inflammatory diseases such as cryopyrin-associated periodic syndromes, gout and atherosclerosis. in addition, gadolinium chloride has been demonstrated to block trpml channel currents, as well as other transient receptor potential (trp) channels.1. lee gs, subramanian n, kim ai, et al. the calcium-sensing receptor regulates the nlrp3 inflammasome through ca2+ and camp. nature, 2012, 492(7427): 123-127.2. nagata k, zheng l, madathany t, et al. the varitint-waddler (va) deafness mutation in trpml3 generates constitutive, inward rectifying currents and causes cell degeneration. proceedings of the national academy of sciences of the united states of america, 2008, 105(1): 353-358.3. del favero g, florio c, codan b, et al. the stretch-activated channel blocker gd3+ reduces palytoxin toxicity in primary cultures of skeletal muscle cells. chemical research in toxicology, 2012, 25(9): 1912-1920.

storage

Desiccate at RT