2-HYDROXY-5-NITROBENZYL BROMIDE

Product Name: 2-HYDROXY-5-NITROBENZYL BROMIDE
CAS No.: 772-33-8
Chemical Name: 2-HYDROXY-5-NITROBENZYL BROMIDE
Synonyms: KOSHLAND I;KOSHLAND REAGENT;KOSHLAND'S REAGENT;KOSHLAND'S REAGENT I;Koshland's reagent 1;Koshland's Reagent 1;α-bromo-4-nitro-o-creso;α-bromo-4-nitro-o-cresol;a-Bromo-4-nitro-o-cresol;α-bromo-4-nitro-o-cresol
CBNumber: CB5229370
Molecular Formula: C7H6BrNO3
Formula Weight: 232.03
MOL File: 772-33-8.mol

More

Less

2-HYDROXY-5-NITROBENZYL BROMIDE Property

Melting point:: 144-149 °C(lit.)
Boiling point:: 383.0±32.0 °C(Predicted)
Density: 1.795
refractive index: 1.6090 (estimate)
storage temp.: 2-8°C
solubility: chloroform: soluble25mg/mL, clear, yellow
pka: 6.16±0.30(Predicted)
form: Crystalline Powder
color: Beige to light brown
BRN: 1868798
CAS DataBase Reference: 772-33-8(CAS DataBase Reference)
EPA Substance Registry System: Phenol, 2-(bromomethyl)-4-nitro- (772-33-8)

More

Less

Safety

Hazard Codes: C
Risk Statements: 34
Safety Statements: 26-36/37/39-45
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
TSCA: Yes
HazardClass: 8
PackingGroup: III
HS Code: 29089990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 162906
Product name: 2-Hydroxy-5-nitrobenzyl bromide
Purity: 90%
Packaging: 5g
Price: $68.9
Updated: 2024/03/01

TCI Chemical

Product number: H0601
Product name: 2-Hydroxy-5-nitrobenzyl Bromide
Purity: >95.0%(T)
Packaging: 5g
Price: $147
Updated: 2024/03/01

TRC

Product number: H950893
Product name: 2-Hydroxy-5-nitrobenzyl Bromide
Packaging: 5g
Price: $45
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK247575
Product name: 2-Hydroxy-5-nitrobenzyl Bromide
Purity: 95%
Packaging: 5g
Price: $38
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0011683
Product name: 2-HYDROXY-5-NITRO BENZYL BROMIDE
Purity: 95.00%
Packaging: 5G
Price: $830.74
Updated: 2021/12/16

More

Less

2-HYDROXY-5-NITROBENZYL BROMIDE Chemical Properties,Usage,Production

Chemical Properties

Beige to yellow crystalline powder

Uses

Reagent for sulfhydryl modification.1

Uses

2-Hydroxy-5-nitrobenzyl bromide is a chemical reagent that reacts with and modifies chemically the tryptophan portion of protein molecules..

Uses

2-Hydroxy-5-nitrobenzyl bromide was used in covalent modification of tryptophan and tryptophan residues in monoclonal immunoglobulin. It was also used as reagent for sulfhydryl modification

Synthesis Reference(s)

Journal of the American Chemical Society, 86, p. 1448, 1964 DOI: 10.1021/ja01061a045

General Description

2-Hydroxy-5-nitrobenzyl bromide is a protein modifying reagent.

Purification Methods

Crystallise the bromide from *benzene or *benzene/ligroin. It is slightly soluble in EtOH, soluble in *C6H6 and AcOH, and very soluble in ligroin. [Beilstein 6 H 367.]

2-HYDROXY-5-NITROBENZYL BROMIDE Preparation Products And Raw materials

Raw materials

Hydrogen bromide Benzene 4-Nitrophenol Phosphorus tribromide Dimethoxymethane Sulfuric acid

Preparation Products

More

Less

2-HYDROXY-5-NITROBENZYL BROMIDE Suppliers

Americas 1 Belgium 3 China 54 Europe 1 France 1 Germany 1 India 11 Japan 1 Slovakia 1 Switzerland 2 United Kingdom 8 United States 21 Global 105

Hangzhou Yaoruiyicheng Biological Medicine Co., Ltd

Tel: 18072846723; 18072846723
Email: caigou1@witofly.com
Country: China
ProdList: 3127
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44688
Advantage: 61

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18738
Advantage: 57

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 021-51613915-820 13611835272
Fax: 021 51613951
Email: mmwang@sunwaypharm.cn
Country: China
ProdList: 9734
Advantage: 57

772-33-8, 2-HYDROXY-5-NITROBENZYL BROMIDERelated Search:

Cresol Cresol o-Cresol 2-METHOXY-5-NITROBENZYL BROMIDE 2-Methyl-4-nitrophenol 3-Nitrobenzyl bromide 2-(BROMOMETHYL)PHENOL 4-AMINO-2-METHYLPHENOL 2-HYDROXY-5-NITROBENZYL BROMIDE Benzyl bromide

KOSHLAND I

KOSHLAND REAGENT

KOSHLAND'S REAGENT

KOSHLAND'S REAGENT I

ALPHA-BROMO-4-NITRO-2-CRESOL

ALPHA-BROMO-4-NITRO-O-CRESOL

2-BROMOMETHYL-4-NITROPHENOL

2-HYDROXY-5-NITROBENZYL BROMIDE

2-(bromomethyl)-4-nitro-pheno

o-Cresol, alpha-bromo-4-nitro-

Phenol, 2-(bromomethyl)-4-nitro-

α-bromo-4-nitro-o-cresol

α-Bromo-4-nitro-o-cresol, 2-Bromomethyl-4-nitrophenol, Koshland I, Koshlands Reagent I

a-Bromo-4-nitro-o-cresol

a-Bromo-4-nitro-o-methylphenol

BETA-1-BROMO-4-NITRO-O-CRESOL

2-Hydroxy-5-nitrobenzyl bromide ,95%

2-Hydroxy-5-nitrobenzyl bromide,α-Bromo-4-nitro-o-cresol, 2-Bromomethyl-4-nitrophenol, Koshland I, Koshland’s Reagent I

alpha-Bromo-4-nitro-o-cresol Koshland's Reagent

2-Hydroxy-5-nitrobenzyl bromide 90%

Koshland's reagent 1

alpha-Bromo-4-nitro-o-cresol,95%

alpha-Bromo-4-nitro-o-cresol,98%

2-Hydroxy-5-nitrobenzylBromide&gt

α-bromo-4-nitro-o-cresol

α-bromo-4-nitro-o-creso

Koshland's Reagent 1

772-33-8

73-1

HOC6H3NO2CH2Br

Building Blocks

BioChemical

Organic Building Blocks

Proteomics and Protein Expression

Protein Modification

Proteomics

Reagents for tryptophan modification

Oxygen Compounds

Phenols

Specific Amino Acid Modification

Building Blocks

C6 to C8

Chemical Synthesis

Organic Building Blocks

Oxygen Compounds

Phenols