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IDAZOXAN HYDROCHLORIDE

Product Name
IDAZOXAN HYDROCHLORIDE
CAS No.
79944-56-2
Chemical Name
IDAZOXAN HYDROCHLORIDE
Synonyms
RX 781094A;IdazoxanHCl;Idazoxan hydrochlori;IDAZOXAN HYDROCHLORIDE;(+/-)-Idazoxan Monohydrochloride;Idazoxan hydrochloride, 10 mM in DMSO;2-(1,4-BENZODIOXAN-2-YL)-2-IMIDAZOLINE HYDROCHLORIDE;Idazoxan hydrochloride, alpha2 Adrenoceptor antagonist and I2 ligand;RX 781094, (±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride;Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride
CBNumber
CB5236802
Molecular Formula
C11H13ClN2O2
Formula Weight
240.69
MOL File
79944-56-2.mol
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IDAZOXAN HYDROCHLORIDE Property

Melting point:
207-208°
storage temp. 
Store at RT
solubility 
H2O: 300 mg/mL
form 
Powder
color 
White to off-white
Water Solubility 
Soluble to 100 mM in water
Stability:
Hygroscopic
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
7
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I6138
Product name
Idazoxan hydrochloride
Packaging
50mg
Price
$115
Updated
2024/03/01
Sigma-Aldrich
Product number
I6138
Product name
Idazoxan hydrochloride
Packaging
100mg
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
5.04746
Product name
IdazoxanHydrochloride-CAS79944-56-2-Calbiochem
Packaging
50mg
Price
$146
Updated
2022/05/15
Tocris
Product number
0793
Product name
Idazoxan hydrochloride
Purity
≥98%
Packaging
10
Price
$159
Updated
2021/12/16
Tocris
Product number
0793
Product name
Idazoxan hydrochloride
Purity
≥98%
Packaging
50
Price
$647
Updated
2021/12/16
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IDAZOXAN HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

mp 207-209°C

Uses

Idazoxan hydrochloride has been used to study the efficacy of antidepressant treatments that interact with multiple neurotransmitter systems.

Uses

Antiparkinsonian;Alpha2 agonist

Uses

An α-adrenoceptor antagonist; in rat brain Idazoxan is a pure antagonist and it has a selectivity for α2- over α1-receptors markedly superior to Piperoxane, Yohimbine, or Rauwolscine. Antiparkinsonian.

Biological Activity

α 2 -adrenoceptor antagonist, and I 2 ligand, selective over I 1 sites (pK i values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I 1 , I 2 , α 2A , α 2B , and α 2C receptors respectively).

Biochem/physiol Actions

α2-adrenoceptor antagonist; I2?imidazoline receptor agonist; I1?imidazoline receptor antagonist. Idazoxan can antagonize various behaviors generated by ethanol in a preclinical setting. It possesses neuroprotective activity against spinal cord injury, resulted due to experimental autoimmune encephalomyelitis (EAE) in mouse, an animal modal of multiple sclerosis (MS).

IDAZOXAN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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79944-56-2, IDAZOXAN HYDROCHLORIDERelated Search:

2-PHENOXYPROPYLAMINE HYDROCHLORIDE 2-METHOXYACETAMIDINE HYDROCHLORIDE 2,3-DIHYDRO-1,4-BENZODIOXIN-2-YLMETHYLAMINE 2-Isopropoxyphenol propionamidine hydrochloride 2-(2-Methoxyphenoxy)ethylamine 2-PHENOXYACETAMIDINE HYDROCHLORIDE 1,4-Benzodioxan 2-(2-METHOXYPHENOXY)-N-METHYLETHYLAMINE 3-AMINO-1-PHENOXY-2-PROPANOL HYDROCHLORIDE, 98 Idazoxan AKOS BBS-00007965 CHEMBRDG-BB 9070636 1,4-BENZODIOXAN-2-METHYLAMINE, N-METHYL- 2-HYDROXY-PROPIONAMIDINE CHEMBRDG-BB 5482082 1-AMINO-3-PHENOXY-PROPAN-2-OL 2-HYDROXY-ACETAMIDINE HCL

  • (+/-)-Idazoxan Monohydrochloride
  • 2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-iMidazole Hydrochloride
  • RX 781094A
  • 2-(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-4,5-dihydro-1H-iMidazole hydrochloride
  • IDAZOXAN HYDROCHLORIDE
  • 2-(1,4-BENZODIOXAN-2-YL)-2-IMIDAZOLINE HYDROCHLORIDE
  • IdazoxanHCl
  • RX 781094, (±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride
  • Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride
  • Idazoxan hydrochlori
  • RX781094,inhibit,Adrenergic Receptor,RX-781094,Idazoxan,Inhibitor,Beta Receptor,Idazoxan hydrochloride,Imidazoline Receptor
  • Idazoxan hydrochloride, alpha2 Adrenoceptor antagonist and I2 ligand
  • Idazoxan hydrochloride, 10 mM in DMSO
  • 79944-56-2
  • 79944-65-2
  • Adrenoceptor
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals