propionamidine hydrochloride
- Product Name
- propionamidine hydrochloride
- CAS No.
- 3599-89-1
- Chemical Name
- propionamidine hydrochloride
- Synonyms
- Propanamidine HCl;Propanimidamide, HCl;Propionamidine hydrochL;propanimidamide chloride;propionamidine acetic acid;Propioamidine hydrochloride;PROPANAMIDINE HYDROCHLORIDE;Propanamidine hydrochloride 97%;PropaniMidaMide,Monohydrochloride (9CI);Propionamidine hydrochloride, Propanimidamide hydrochloride
- CBNumber
- CB5885172
- Molecular Formula
- C3H9ClN2
- Formula Weight
- 108.56996
- MOL File
- 3599-89-1.mol
propionamidine hydrochloride Property
- Melting point:
- 298.5 °C
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C3H8N2.ClH/c1-2-3(4)5;/h2H2,1H3,(H3,4,5);1H
- InChIKey
- DFWRZHZPJJAJMX-UHFFFAOYSA-N
- SMILES
- C(=N)(N)CC.Cl
Safety
- HS Code
- 2925290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P839090
- Product name
- PropioamidineHydrochloride
- Packaging
- 5g
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 090341
- Product name
- Propioamidine hydrochloride
- Purity
- 95+%
- Packaging
- 1g
- Price
- $341
- Updated
- 2021/12/16
- Product number
- CHM0031929
- Product name
- PROPIONAMIDINE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $511.35
- Updated
- 2021/12/16
- Product number
- CHM0031929
- Product name
- PROPIONAMIDINE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $602.7
- Updated
- 2021/12/16
- Product number
- 090341
- Product name
- Propioamidine hydrochloride
- Purity
- 95+%
- Packaging
- 5g
- Price
- $908
- Updated
- 2021/12/16
propionamidine hydrochloride Chemical Properties,Usage,Production
Uses
Propioamidine Hydrochloride acts as a reagent in the synthetic preparation of guanidine.
Synthesis
107-12-0
3599-89-1
The general procedure for synthesizing propionamidine hydrochloride from propionitrile was as follows: with reference to the preparation of propionamide hydrochloride in Example 28, hydrogen chloride gas was passed into a solution of propionitrile (10 g, 142 mmol) in ethanol (8.4 mL) until the total amount was increased by 7.9 g, and the reaction mixture was stirred at room temperature for 21.5 hours. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure, the residue was suspended in ethanol (5.5 mL) and the suspension was cooled to -10 °C. A methanol solution of 8N ammonia (17.8 mL) was slowly added to the cooled suspension and stirring was continued for 28 hours at room temperature. At the end of the reaction, the insoluble material was removed by filtration, and the filtrate was concentrated under reduced pressure to give propionamidine hydrochloride (10.8 g, 70% yield) in white crystal form. The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 1.17 (3H, t, J = 7.6 Hz), 2.40 (2H, q, J = 7.7 Hz), 8.77 (2H, br s), 9.07 (2H, br s).
References
[1] Patent: EP2471793, 2012, A1. Location in patent: Page/Page column 48
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 15, p. 4777 - 4791
[3] Patent: WO2011/130628, 2011, A1. Location in patent: Page/Page column 177-178
[4] Patent: US2013/102595, 2013, A1. Location in patent: Paragraph 0370; 0371
[5] Patent: JP2015/187145, 2015, A. Location in patent: Paragraph 0324
propionamidine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from propionamidine hydrochloride manufacturers
- Product
- propionamidine hydrochloride 3599-89-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-09-27
- Product
- propionamidine hydrochloride 3599-89-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-08