Oxymetazoline hydrochloride Property

Melting point:

approximate 300℃ (dec.)

storage temp. 

Store at RT

solubility 

H₂O: soluble

form 

solid

color 

white

PH

pH (50g/L, 25℃) : 4.0～6.5

Water Solubility 

Soluble to 50 mM in water

Stability:

Toxic

CAS DataBase Reference

2315-02-8(CAS DataBase Reference)

Safety

Hazard Codes 

T+

Risk Statements 

28

Safety Statements 

22-28-36/37/39-45

RIDADR 

UN 2811 6.1/PG 1

WGK Germany 

3

RTECS 

SK1225000

HazardClass 

6.1(a)

PackingGroup 

II

HS Code 

2933290000

Toxicity

LD50 orally in mice: 10 mg/kg (Hotovy)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H318Causes serious eye damage

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Oxymetazoline hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Originator

Nasivin,Merck,W. Germany ,1961

Uses

Oxymetazoline hydrochloride is an α1-AR and α2-AR adrenergic receptor agonist and used as Vasoconstrictor, a nasal decongestant.

Uses

Vasoconstrictor, used as a nasal decongestant. An ingredient of Drixin.

Uses

muscle relaxant (smooth), cerebral vasodilator

Definition

ChEBI: A hydrochloride salt resulting from the reaction of equimolar quantities of oxymetazoline and hydrogen chloride. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used to relieve nasal con estion.

Manufacturing Process

10 grams 2,6-dimethyl-3-hydroxy-4-tertiary butylbenzylcyanide (produced by chloromethylation of 2,4-dimethyl-6-tertiary butyl-phenol with formaldehyde and HCl and conversion of the substituted benzyl chloride with NaCN; crystals, from alcohol, melting at 135° to 137°C) and 10.7 grams ethylenediaminemono-p-toluenesulfonate are heated in an oil bath to approximately 235°C for 1? hours, whereby ammonia is evolved. The free base is obtained from the p-toluene-sulfonic acid imidazoline salt which is difficultly soluble in water, by conversion with 50 cc of a 10% NaOH solution. Said base is recrystallized from benzene, and 7.5 grams (62% of the theoretical yield) 2-(2',6'-dimethyl3'-hydroxy-4'-tertiary butylbenzyl)-2-imidazoline, MP 180° to 182°C, are obtained.
By dissolving the free base in an ethyl alcohol solution of hydrochloric acid and adding ether, the hydrochloride can be produced in the usual manner. Said hydrochloride melts, when recrystallized from alcoholic ether, at 300° to 303°C and is decomposed

brand name

Ocuclear (Schering-Plough); Visine (Pfizer).

Therapeutic Function

Nasal decongestant

Biological Activity

Partial α 2A adrenoceptor agonist and α 1A agonist. Agonist/antagonist activity at 5-HT receptors.